Size of the Lesions of Superficial Punctate Keratitis in Dry Eye Syndrome Observed With a Slit Lamp

Courrier, Emilie; Lépine, Thierry; Hor, G.; Fournier, Corinne; Hé, Zhiguo; Chikh, M.; Urrea, Caroline; Anazi, Fahran-Falgi Al; Thuret, Gilles; Gain, Philippe

doi:10.1097/ico.0000000000000846

Cited by 9 publications

(7 citation statements)

References 10 publications

(9 reference statements)

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“…However, both methods focus on the anterior segment and overlook other areas also involved in visual system, especially ignoring the optic tract and visual cortex. ods for the diagnosis of CU [4,5], while genomic technology is also gradually applied for corneal ulcer and other ophthalmic diseases [6][7][8]. However, both methods focus on the anterior segment and overlook other areas also involved in visual system, especially ignoring the optic tract and visual cortex.…”

Section: Introductionmentioning

confidence: 99%

“…Corneal scarring may also occur after treatment for corneal ulcers. Slit lamp and fluorescein staining are common methods for the diagnosis of CU [ 4 , 5 ], while genomic technology is also gradually applied for corneal ulcer and other ophthalmic diseases [ 6 , 7 , 8 ]. However, both methods focus on the anterior segment and overlook other areas also involved in visual system, especially ignoring the optic tract and visual cortex.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal Intrinsic Functional Hubs in Corneal Ulcer: Evidence from a Voxel-Wise Degree Centrality Analysis

Chen

Huang

Liang

et al. 2022

JCM

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Background: Numerous anterior neuroimaging researches have revealed that corneal ulcers (CU) are related to changes in cerebral anatomic structure and functional area. Nonetheless, functional characteristics of the brain’s network organization still show no definite research results. The study was designed to confirm CU-associated spatial centrality distribution functional network of the whole cerebrum and explore the mechanism through which the larvaceous changed the intrinsic functional hubs. Material and Methods: In this study, 40 patients with CU and 40 normal controls (matched in sex, age, and education level) were enrolled in this study to undergo resting-state functional magnetic resonance imaging (fMRI) scans. The differences between the groups were determined by measuring the voxel-wise degree centrality (DC) throughout the whole cerebrum. For the purpose of assessing the correlation between abnormal DC value and clinical variables, the Linear correlation analysis was used. Results: Compared with normal controls (NCs), CU patients revealed high DC values in the frontal lobe, precuneus, inferior parietal lobule, posterior cingulate, occipital lobe, and temporal lobe in the brain functional connectivity maps throughout the brain. The intergroup differences also had high similarity on account of different thresholds. In addition, DC values were positively related to the duration of CU in the left middle frontal gyrus. Conclusions: The experimental results revealed that patients with CU showed spatially unnatural intrinsic functional hubs whether DC values increased or decreased. This brings us to a new level of comprehending the functional features of CU and may offer useful information to make us obtain a clear understanding of the dysfunction of CU.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abnormal Intrinsic Functional Hubs in Corneal Ulcer: Evidence from a Voxel-Wise Degree Centrality Analysis

Chen

Huang

Liang

et al. 2022

JCM

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“…Slit lamp, sodium fluorescein staining, and confocal laser scanning microscope are the main detection methods in the current clinical process of CU diagnosis and treatment. [4][5][6] These traditional methods are exclusively focused on the anterior segment of the eye, ignoring variations in the visual center and cerebral cortex.…”

Section: Introductionmentioning

confidence: 99%

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study</p>

Tang

Fang

et al. 2020

NDT

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To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using restingstate functional magnetic resonance imaging. Patients and Methods: A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample t-test, receiver operating characteristic curve, and Pearson's correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients. Results: The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions. Conclusion: CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU.

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“…Punctate epithelial erosions (PEE) are a common feature of various ocular surface diseases, including dry eye disease (DED) 2–4. The elementary lesions that characterize this condition are small epithelial erosions staining with fluorescein scattered over the corneal surface, which sometimes become confluent in larger areas where single lesions are no longer visible 5. The density and the extent of the corneal staining provide useful information to assess disease severity and to monitor the response to treatment; additionally, its morphological pattern as well as its topographical distribution over the corneal area may provide a clue to the underlying aetiology 6…”

Section: Introductionmentioning

confidence: 99%

Assessment of Corneal Fluorescein Staining in Different Dry Eye Subtypes Using Digital Image Analysis

Pellegrini

Bernabei

Moscardelli

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose: To describe a new objective technique of digital image analysis for the quantification and the morphological characterization of corneal staining in the setting of dry eye disease (DED), and to apply it to distinguish Sjögren syndrome (SS) from ocular graft versus-host disease (oGVHD).Methods: Slit-lamp photographs of corneal staining obtained from 40 patients with DED (20 with SS and 20 with oGVHD; mean age 60.7 6 12.3 years) were evaluated. Images were subjectively graded using Oxford and National Eye Institute (NEI) scales, the staining pattern was classified as micropunctate, macropunctate, coalescent, or patch. The corneal staining index (CSI) was calculated automatically using the software ImageJ 1.51s. Particles analysis was used to calculate mean area, circularity, and roundness of staining spots.Results: CSI was significantly correlated with Oxford and NEI scales (respectively Rs ¼ 0.823 and Rs ¼ 0.773; both P , 0.001), and showed a good interobserver reliability (intraclass correlation coefficient [ICC] ¼ 0.988 [95% confidence interval [CI]: 0.978-0.994]). The mean area of staining spots calculated with particles analysis was significantly correlated with the subjective classification of the staining pattern (Rs ¼ 0.550, P , 0.001). The circularity and roundness of staining spots were significantly higher in oGVHD patients compared with SS (respectively, 0.51 6 0.11 vs. 0.44 6 0.10, P ¼ 0.040; 0.61 6 0.03 vs. 0.59 6 0.02, P ¼ 0.004). Sensitivity and specificity to distinguish oGVHD from SS were respectively 65.0% and 60% for circularity and 80.0% and 70.0% for roundness. Conclusions:The new algorithm showed good reliability and was well correlated with the traditional subjective grading scales. Particles analysis for the objective assessment of the staining pattern may help to differentiate patients with oGVHD from those with SS.Translational Relevance: The digital image analysis technique may be a reliable alternative to evaluate corneal staining objectively in the clinic and in clinical trials.

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Size of the Lesions of Superficial Punctate Keratitis in Dry Eye Syndrome Observed With a Slit Lamp

Cited by 9 publications

References 10 publications

Abnormal Intrinsic Functional Hubs in Corneal Ulcer: Evidence from a Voxel-Wise Degree Centrality Analysis

Abnormal Intrinsic Functional Hubs in Corneal Ulcer: Evidence from a Voxel-Wise Degree Centrality Analysis

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study</p>

Assessment of Corneal Fluorescein Staining in Different Dry Eye Subtypes Using Digital Image Analysis

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