Size Limitations for the Formation of Ordered Striped Nanoparticles

Carney, Randy P.; DeVries, Gretchen A.; Dubois, Cédric; Kim, Hyewon; Kim, Jin Young; Singh, Chetana; Ghorai, Pradip Kr.; Tracy, Joseph B.; Stiles, Rebecca L.; Murray, Royce W.; Glotzer, Sharon C.; Stellacci, Francesco

doi:10.1021/ja077383m

Cited by 100 publications

(103 citation statements)

References 19 publications

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“…However, recent work indicated that surface structure does not significantly affect the proposenity for small AuNPs to fuse with single component bilayers 25 , and furthermore small AuNPs exhibit similar structural characteristics in water independent of morphology 44 . Experimental evidence also suggests that for small AuNPs, the two ligand species fully separate to form Janus particles 49 . However, the expected electrostatic attraction between the MUS end groups and the bilayer would cause the MUS ligands in the Janus morphology to approach the surface in the same orientation as for an all-MUS particle 20 .…”

Section: Resultsmentioning

confidence: 99%

“…We used polydisperse AuNPs with a mean gold core size of 5-6 nm coated with a 2:1 MUS:OT monolayer [24][25][26][27] as an intermediate composition between the all-MUS and 1:1 MUS:OT compositions studied in simulations. These AuNPs were large enough to not form Janus morphologies 49 but sufficiently small that insertion would be expected 25,32 . Details of particle characterization are in the Supplementary Methods.…”

Section: Resultsmentioning

confidence: 99%

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Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

et al. 2014

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Recent work has demonstrated that charged gold nanoparticles (AuNPs) protected by an amphiphilic organic monolayer can spontaneously insert into the core of lipid bilayers to minimize the exposure of hydrophobic surface area to water. However, the kinetic pathway to reach the thermodynamically stable transmembrane configuration is unknown. Here, we use unbiased atomistic simulations to show the pathway by which AuNPs spontaneously insert into bilayers and confirm the results experimentally on supported lipid bilayers. The critical step during this process is hydrophobic-hydrophobic contact between the core of the bilayer and the monolayer of the AuNP that requires the stochastic protrusion of an aliphatic lipid tail into solution. This last phenomenon is enhanced in the presence of high bilayer curvature and closely resembles the putative pre-stalk transition state for vesicle fusion. To the best of our knowledge, this work provides the first demonstration of vesicle fusion-like behaviour in an amphiphilic nanoparticle system.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

et al. 2014

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“…[ 209 ] where mobility enabled by the particle curvature allows mixed monolayers of immiscible molecules to segregate into nm-scale stripes. [ 210 ] While electro-hydrodynamic co-jetting is limited to production of cylindrical and spherical particles due to surface tension effects, more complex shapes can be produced using microfl uidic strategies. One such technique, called stop fl ow lithography (SFL), enables remarkable control over particle anisotropy and was fi rst demonstrated by Doyle and colleagues.…”

Section: Fabrication and Assembly Of Anisotropic Particlesmentioning

confidence: 99%

Engineering of Micro‐ and Nanostructured Surfaces with Anisotropic Geometries and Properties

Tawfick¹,

Volder²,

Copic³

et al. 2012

Advanced Materials

210

179

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Widespread approaches to fabricate surfaces with robust micro- and nanostructured topographies have been stimulated by opportunities to enhance interface performance by combining physical and chemical effects. In particular, arrays of asymmetric surface features, such as arrays of grooves, inclined pillars, and helical protrusions, have been shown to impart unique anisotropy in properties including wetting, adhesion, thermal and/or electrical conductivity, optical activity, and capability to direct cell growth. These properties are of wide interest for applications including energy conversion, microelectronics, chemical and biological sensing, and bioengineering. However, fabrication of asymmetric surface features often pushes the limits of traditional etching and deposition techniques, making it challenging to produce the desired surfaces in a scalable and cost-effective manner. We review and classify approaches to fabricate arrays of asymmetric 2D and 3D surface features, in polymers, metals, and ceramics. Analytical and empirical relationships among geometries, materials, and surface properties are discussed, especially in the context of the applications mentioned above. Further, opportunities for new fabrication methods that combine lithography with principles of self-assembly are identified, aiming to establish design principles for fabrication of arbitrary 3D surface textures over large areas.

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“…Glotzer theoretically demonstrated that a length mismatch between two dislike thiolates is sufficient to drive the formation of stripe like domains on the surface of gold nanoparticles of diameters in the range 2.5-8.0 nm [32]. For smaller particles the formation of the so-called Janus particles is favored, with the two dislike ligands segregated on two hemispherical surfaces.…”

Section: Monolayer Structurementioning

confidence: 99%

Gold nanoparticles protected by fluorinated ligands: Syntheses, properties and applications

Pengo

Pasquato

2015

Journal of Fluorine Chemistry

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Abstract:The development of fluorinated gold nanoparticles is presently arising and increasing attention across several fields of nanotechnology. The synthetic approaches evolved over time from the use of almost perfluorinated alkanethiols and perfluorinated arylthiols to amphiphilic fluorinated thiols capable of ensuring solubility in conventional organic solvents and water. The interest in these systems stems from the unique properties of both nanosized and fluorous compounds. In perspective, the development of our understanding of the fluorophilic interactions at the nanoscale will allow to devise novel strategies for self-assembly, molecular recognition and new materials for biomedical applications. In this paper we present, through selected examples, the potential of fluorous ligands in the synthesis of gold nanoparticles and the relevance of mastering the properties of these systems in the development of new materials.

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Size Limitations for the Formation of Ordered Striped Nanoparticles

Cited by 100 publications

References 19 publications

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

Engineering of Micro‐ and Nanostructured Surfaces with Anisotropic Geometries and Properties

Gold nanoparticles protected by fluorinated ligands: Syntheses, properties and applications

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