Size Exclusion Chromatography of Poly(ethylene glycol)

Abstract

Size exclusion chromatography calibrations for polystyrene and poly(ethylene glycol) standard samples in the molecular weight range of (600‐11000) have been obtained in tetrahydrofuran. The Kuhn‐Mark‐Houwink‐Sakurada constants of poly(ethylene glycol) in tetrahydrofuran were determined, and poly(ethylene glycol) chromatograms were evaluated according to primary and universal calibration methods. The molecular weights determined from universal curves were substantially lower than those obtained from primary curves. The Coll and Prusinowski universal calibration procedure gave better results than the calibration of Benoit et al.

Amphiphilic Diblock Copolymers Bearing Poly(Ethylene Glycol) Block: Hydrodynamic Properties in Organic Solvents and Water Micellar Dispersions, Effect of Hydrophobic Block Chemistry on Dispersion Stability and Cytotoxicity

“…It should be noted that the average value of Huggins constant k H equals to 0.3 ± 0.1, which indicates that THF may be considered as a thermodynamically good solvent for all the studied copolymers. The obtained values of intrinsic viscosity of the copolymers fall in the range from 0.13 to 0.25 dL/g (see Table 2 ), and this result is in good agreement with the intrinsic viscosity of PEO in THF [ 48 ].…”

Rapid and simple determination of average molecular weight and composition of synthetic polymers via electrospray ionization‐mass spectrometry and a Bayesian universal charge deconvolution

“…As with the PSS standards, the M w molecular weight deduced for PEO‐1K is about 20% lower than the reported value. Because the manufacturer provided no information on the method used to appraise the reported M w and given the problems associated with the molecular weight determination of low‐MW polymers using GPC (vide supra), the modest difference between the UniDec and reported average molecular weights most likely results from an overestimation of the reported value 33 34–37 ; such process could explain the low mass distribution centered about 400 Da and the shouldering distribution about 900 Da observed in the deconvoluted mass spectra, something that might be overlooked in the raw mass spectrum (cf.…”

“…Because the manufacturer provided no information on the method used to appraise the reported M w and given the problems associated with the molecular weight determination of low-MW polymers using GPC (vide supra), the modest difference between the UniDec and reported average molecular weights most likely results from an overestimation of the reported value. 33 An alternative explanation could be partial oxidative, thermal, or hydrolytic degradation of PEO, as PEO could degrade in the absence of stabilizers [34][35][36][37] ; such process could explain the low mass distribution centered about 400 Da and the shouldering distribution about 900 Da observed in the deconvoluted mass spectra, something that might be overlooked in the raw mass spectrum (cf. Figures S5 and S7 [supporting information]).…”

Evaluation of halogen chain-end functionality in 2-bromo-2-methylpropanoate esters of poly(oxyalkylene) polymers by MALDI-TOF spectroscopy

“…THF was used as an eluent at a flow rate of 1 mL min -1 at 30°C. The system was calibrated with a linear calibration curve built from polystyrene standards (1,350 to 1,997,000 Da PS), and the correction for the related to changes in the hydrodynamic volumes was carried out with the Kuhn-Mark-Houwnik-Sakurada constants for the PEG-THF system ([] =3.39x10 -4 M 0.66 ) [32].…”