Size Effect of Colloidal Selenium Particles on the Inhibition of LPS-Induced Nitric Oxide Production

Chen, Yue‐Hwa; Chang, Hsiu Ju; Lin, Zong‐Hong; Wang, C. R. Chris

doi:10.1002/jccs.200500058

Cited by 5 publications

(4 citation statements)

References 9 publications

(6 reference statements)

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“…1b), respectively. At the same concentration of Se, the number of particles for 36 nm Nano-Se is roughly one order of magnitude more than that for 90 nm Nano-Se, which is similar to the result reported by Chen et al [34].…”

Section: Resultssupporting

confidence: 89%

Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity

Peng

Zhang

Liu

et al. 2007

Journal of Inorganic Biochemistry

223

117

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It has been shown that 36 nm Nano-Se has lower toxicity than selenite or selenomethionine, but these forms of selenium (Se) all possess similar ability to increase selenoenzyme levels. The size of nanoparticles plays an important role in their biological activity: as expected, 5-200 nm Nano-Se can directly scavenge free radicals in vitro in a size-dependent fashion. However, in Se-deficient cells and Se-deficient mice, the size effect of Nano-Se on increasing selenoenzymes and liver Se disappears unexpectedly. We hypothesize that under conditions of Se deficiency, the avidity of Se uptake mechanisms may be increased to maintain the biosynthesis of selenoenzymes, which are fundamental for redox homeostasis. This increased avidity may override the potential advantage of small size Nano-Se seen under Se-replete conditions, thereby eliminating the size effect. Once selenoenzymes have been saturated, Se uptake mechanisms may downregulate; accordingly, the size effect of Nano-Se can then reappear. To test this hypothesis, Se-deficient mice were administered either 36 or 90 nm Nano-Se at supranutritional doses, in both a short-term model and a single-dose model. Under these conditions, Nano-Se showed a size effect on Se accumulation and glutathione S-transferase (GST) activity. A size effect of Nano-Se was found in 15 out of 18 total comparisons between sizes at the same dose and time in the two models. Furthermore, the magnitude of the size effect was more prominent on Se accumulation than on GST activity. GST is strictly regulated by transcriptional and translational mechanisms, so its increase in activity normally does not exceed 3-fold. In contrast, the homeostasis of Se accumulation is not as tightly controlled. In the present experiments, GST activity had reached or was approaching saturation, but liver Se was far below saturation. Therefore, our results strongly suggest that the saturation profile of the tested biomarker has an impact on the size effect of Nano-Se. Since both GST and small molecular weight selenocompounds accumulated in vivo are important intermediates for chemoprevention by Se, our results also suggest that Nano-Se should be most effective as a chemopreventive agent at smaller particle size.

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Section: Resultssupporting

confidence: 89%

Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity

Peng

Zhang

Liu

et al. 2007

Journal of Inorganic Biochemistry

223

117

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“…Частицы восстановленного селена, несущие антигены ППД (Сe-ППД). В качестве восстановителя при приготовлении частиц селена использовали тиосульфат натрия [13]. В 1300 мкл деионизованной воды вносили 400 мкл раствора 7,5 мг/мл селенистой кислоты, 100 мкл 30%-го тиосульфата натрия; раствор выдерживали при комнатной температуре.…”

Section: изучены адъювантные свойства мицелл неионогенного детергентаunclassified

“…Общеизвестным фактом является внутриклеточный паразитизм микобактерий в макрофагах, моноцитах и дендритных клетках [19]. Натуральные лимфоциты-киллеры способны убивать микобактерий внутри зараженных моноцитов [11], а Т-лимфоциты способны убивать макрофагов, несущих живых M. tuberculosis [13]. Между дендритными клетками и -Т-клетками, осуществляющими иммунный ответ на M. tuberculosis, устанавливается взаимная стимуляция.…”

Section: изучены адъювантные свойства мицелл неионогенного детергентаunclassified

“…Введение. Тритикале -новый вид хлебных злаков, обладающий высоким биологическим потенциалом и пищевой ценностью [5,8,10,12,13]. Использование тритикале как продовольственной культуры в нашей стране остается до сих пор крайне ограниченным.…”

Section: The Adjuvant Properties Of Micelles Of Nonionic Detergent Anunclassified

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Selenium nanoparticles and micells are tools for tuberculosis prevention

Vidyagina¹

2018

asj

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A study was made of the blood samples of small cattle for brucellosis with various serological reactions when testing a split-conjugated vaccine against animal brucellosis three and a half, four and a half months and nine months after immunization. Positive reaction of small cattle to brucellosis in the complement fixation reaction and the agglutination reaction of 40.7% of sheep and goats, and 44.4% of animals in Ros-Bengal after 3.5 months of vaccination. The vaccine has a high immunogenicity against goats, a high enough antibody titer in blood three and a half months after vaccination, when tested with agglutination and Rose-Bengal, breakdown was detected in 83.3% of animals, and in the complement fixation reaction it was 66.7%, which will, in our opinion, effectively use this vaccine in the fight against goat brucellosis. Immunized sheep in the complementfixation reaction and Rose-Bengal assay reacted positively only in 33.3% of cases. When the agglutination reaction was established three and a half months after the introduction of the vaccine-in 28.6% of the animals, in connection with the data obtained, we recommend looking for new immunoprotectors capable of enhancing the humoral immune response of sheep to the antigen of the tested anti-brucellosis vaccine. Nine months after the vaccination of the split-conjugated vaccine in all blood samples of small cattle (sheep and goats) with all of the above reactions, there was no positive test, which indicates the disappearance and complement-binding and agglutinating antibodies from the bloodstream of animals, and thus the opportunity is given differentiate postvaccinal antibodies in the blood serum of animals, from post-infection, in the case of their detection within the time specified above. EXPERIMENTAL APPLICATION OF A SPLIT-CONJUGATED VACCINE AGAINST ANIMAL BRUCELLOSIS IN SMALL CATTLE

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Development and stability of novel selenium colloidal particles complex with peanut meal peptides

Tang

et al. 2020

LWT

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Size Effect of Colloidal Selenium Particles on the Inhibition of LPS-Induced Nitric Oxide Production

Cited by 5 publications

References 9 publications

Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity

Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity

Selenium nanoparticles and micells are tools for tuberculosis prevention

Development and stability of novel selenium colloidal particles complex with peanut meal peptides

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