Size-dependent maternal-fetal transfer and fetal developmental toxicity of ZnO nanoparticles after oral exposures in pregnant mice

Teng, Chuanfeng; Jia, Jianbo; Wang, Zhiping; Sharma, Virender K.; Yan, Bing

doi:10.1016/j.ecoenv.2019.109439

Cited by 66 publications

(40 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Teng et al discovered that the organogenesis period (GD 7-16) was more vulnerable to such toxicity compared with the peri-implantation period (GD 1-10) of pregnancy. At the same time, they found that ZnO NPs could affect placental weight, fetal rat weight, and vitality in the 200 mg/kg group [24].…”

Section: Discussionmentioning

confidence: 90%

Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress

et al. 2020

View full text Add to dashboard Cite

ZnO NPs have been assessed to show adverse effects on reproductive organs, but the molecular mechanisms of reproductive toxicity have not been sufficiently studied. In this research, the dosage effects from the oral exposure of ZnO NPs (30 nm) to pregnant mice in gestation day 10.5 to 17.5 was analyzed. Pregnant mice exposed to ZnO NPs induced dam injury, mice fetal growth restriction, and the fetus number decreased. The pathological evaluation showed that ZnO NPs exposure caused placental spongiotrophoblast area decease and structural damage. The RT-qPCR and immunocytochemistry data indicated that ZnO NPs could induce placenta oxide stress, endoplasmic reticulum stress responses, apoptosis, and altered placental function. These findings indicated that ZnO NPs could induce dam injury and fetal growth restriction. Reproductive toxicity of ZnO NPs may be due to placental injury and function alteration caused by apoptosis, oxide stress, and endoplasmic reticulum stress after ZnO NPs exposure.

show abstract

Section: Discussionmentioning

confidence: 90%

Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress

et al. 2020

View full text Add to dashboard Cite

show abstract

“…All studies except two [ 68 , 77 ] showed the translocation of Ag NPs [ 47 ], CdO NPs [ 66 ], and DEPs [ 91 , 92 ] to the placenta and/or fetus following maternal inhalation exposure. In total, 7 included in vivo animal studies revealed a size- or dose-dependent distribution of NPs from mother to fetus, meaning that smaller particles administered in higher doses tend to accumulate more in placental and embryonic/fetal tissue [ 27 , 46 , 55 , 57 , 62 , 73 , 85 ]. For instance, measured cadmium (Cd) levels in mice pups were positively associated with the injected CdTe/CdS QD dose their mothers received.…”

Section: Resultsmentioning

confidence: 99%

“… [ 84 ] Sprague Dawley rats 24 ZnO NPs < 100 a oral/ 0 or 500 mg/kg/ 14 days before mating-day 4 of lactation g ICP-MS / Significantly higher levels of Zn in liver and kidneys, but not in blood and brain of rat offspring exposed to ZnO NPs before, during, and after gestation. [ 85 ] CD-1 mice 40 ZnO NPs 13.2 ± 3.7, 57.1 ± 4.1, or 1900 ± 504 b oral/ 0 or 7.2 mg/mouse/ GD1–10 or 7–16 f ICP-MS / Zn detected in the placentae of mothers exposed to ZnO NPs during early gestation in contrast to mothers exposed to bulk ZnO. Only the smallest ZnO NPs crossed the placenta to reach the fetus.…”

Section: Resultsmentioning

confidence: 99%

“…This supports the finding that the placenta is not an impenetrable barrier, as already confirmed for other xenobiotics such as drugs and alcohol [ 131 ]. In animal models, transplacental passage has been reported for Ag NPs [ 47 – 54 ], Al 2 O 3 NPs [ 44 ], Au NPs [ 57 , 59 – 61 ], CeO 2 NPs [ 67 ], DEP [ 91 ], QDs [ 62 ], SiO 2 NPs [ 70 , 71 , 73 , 74 ], TiO 2 NPs [ 73 , 75 , 76 , 78 , 80 , 81 ], ZnO NPs [ 83 – 85 ], ZrO 2 NPs [ 86 ], Fe 2 O 3 NPs [ 69 ], C60 fullerenes [ 87 ], PGMA NPs [ 89 ], and PS NPs [ 27 ]. Among these particles, only Ag NPs [ 37 ], Au NPs [ 31 , 38 ], and PS NPs [ 40 – 43 ] showed transplacental transfer in an ex vivo perfusion model, whereas SiO 2 NPs [ 25 ] and TiO 2 NPs [ 34 ] were retained in the placental tissue.…”

Section: Discussionmentioning

confidence: 99%

“…First, the effect of particle size on transplacental transfer was addressed by 6 included studies [ 27 , 55 , 57 , 62 , 73 , 85 ]. For instance, Yamashita et al i.v.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies

et al. 2020

View full text Add to dashboard Cite

Fetal development is a crucial window of susceptibility in which exposure may lead to detrimental health outcomes at birth and later in life. The placenta serves as a gatekeeper between mother and fetus. Knowledge regarding the barrier capacity of the placenta for nanoparticles is limited, mostly due to technical obstacles and ethical issues. We systematically summarize and discuss the current evidence and define knowledge gaps concerning the maternal-fetal transport and fetoplacental accumulation of (ultra)fine particles and nanoparticles. We included 73 studies on placental translocation of particles, of which 21 in vitro/ex vivo studies, 50 animal studies, and 2 human studies on transplacental particle transfer. This systematic review shows that (i) (ultra)fine particles and engineered nanoparticles can bypass the placenta and reach fetal units as observed for all the applied models irrespective of the species origin (i.e., rodent, rabbit, or human) or the complexity (i.e., in vitro, ex vivo, or in vivo), (ii) particle size, particle material, dose, particle dissolution, gestational stage of the model, and surface composition influence maternal-fetal translocation, and (iii) no simple, standardized method for nanoparticle detection and/or quantification in biological matrices is available to date. Existing evidence, research gaps, and perspectives of maternal-fetal particle transfer are highlighted.

show abstract

Structurally Optimized Fluorinated Small‐Sized Graphene Oxide for Enhanced Magnetic Resonance Imaging during Pregnancy

Xu,

Chen,

Wang

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Gadolinium‐based complex contrast agents (GBCAs), frequently applied in magnetic resonance imaging (MRI), are associated with severe acute anaphylactic shock and incurable nephrogenic systemic fibrosis. Besides, the repeated use of GBCAs may result in the accumulation in various tissues. Given these potential adverse effects, GBCAs have not been well used during pregnancy. Herein, a novel metal‐free T2‐weighted MRI nanoprobe, designated fluorinated small‐sized graphene oxide with optimized fluorine content (LF‐sGO), is developed via graphene oxide materials. By introducing specific polar C─F bonds onto the small‐sized graphene oxide (sGO) skeleton, the prepared nanoprobe exhibits excellent water solubility, as well as superior MRI capabilities, thereby furnishing high‐resolution MRI anatomical information. Furthermore, the free radicals on LF‐sGO stabilized by C─F bonds confer LF‐sGO enrichment in the tumor region, enabling comprehensive imaging capability. The cytotoxicity study in vitro indicates that LF‐sGO has the potential to serve as a biocompatible imaging probe. Moreover, detailed in vivo studies on pregnant mice and zebrafish adequately demonstrate that microinjection of LF‐sGO does not induce dysontogensis and teratogenesis. This study successfully showcases a metal‐free nanoprobe that exhibits exceptional MRI capabilities for the purpose of tumor diagnosis. Notably, this nanoprobe holds promise for safe and effective tumor diagnosis during pregnancy.

show abstract

Size-dependent maternal-fetal transfer and fetal developmental toxicity of ZnO nanoparticles after oral exposures in pregnant mice

Cited by 66 publications

References 41 publications

Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress

Nano Zinc Oxide Induced Fetal Mice Growth Restriction, Based on Oxide Stress and Endoplasmic Reticulum Stress

Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies

Structurally Optimized Fluorinated Small‐Sized Graphene Oxide for Enhanced Magnetic Resonance Imaging during Pregnancy

Contact Info

Product

Resources

About