Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy

Abstract

Background: We have developed magnetic cationic liposomes (MCLs) that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia. The heating performance of the MCLs is significantly affected by the property of the incorporated magnetite nanoparticles. We estimated heating capacity of magnetite nanoparticles by measuring its specific absorption rate (SAR) against irradiation of the alternating magnetic field (AMF).

Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use

“…The obtained SAR values of all the dispersions were nearly identical, around 11 W/g magnetite. This value is fully consistent with others found in the literature, albeit the choice of the parameters of the magnetic field and the magnetization and particle size of the particles among its other relevant properties have tremendous effect on the SAR values [40][41][42][43][44]. The observed heating efficiency of our samples should be sufficient to rise temperature ~5°C above body temperature necessary to induce apoptosis and necrosis of cells in the case when the same particle concentration can be achieved by accumulating them in specific target locations during administration.…”

Study of carbon encapsulated iron oxide/iron carbide nanocomposite for hyperthermia

“…The heat-capacity of magnetite is negligible because of its low concentration, and thus a heat capacity for water (4.18 J g À 1 K À 1 ) was taken as the sample's heat capacity [21]. DT/Dt is the initial slope of the time-dependent temperature curve.…”

Smart Drug Delivery Systems

“…Magnetic drug delivery systems formed using this design strategy have shown promise for clinical evaluation and treatment of brain tumor patients using a tandem approach involving acoustic and magnetic targeting of tissue across the blood-brain barrier. The second strategy we focus on is a multidomain ferromagnetic (FM) particle system [70] for the induction of localized heat through magnetic hypothermia. As discussed previously, the multidomain structure allows for the generation of heat energy in response to an alternating magnetic field.…”