Size Dependent Cellular Uptake of Rod-like Bionanoparticles with Different Aspect Ratios

Liu, Xiangxiang; Wu, Fuchao; Tian, Ye; Wu, Man; Zhou, Quan; Jiang, Shidong; Niu, Zhongwei

doi:10.1038/srep24567

Cited by 95 publications

(93 citation statements)

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“…1D rod‐like structures exist in numerous natural and anthropogenic systems, where the 1D aspect ratios of length to diameter exceed 10:1. Naturally occurring 1D structures are found in a variety of environments, such as ice crystals, fibers, and viruses, and have impacts spanning from atmospheric processes to human health (see Figure ). Synthetic 1D materials, such as nanotubes and nanorods are of interest for a variety of industrial applications with reported synthesis of 1D structures composed of metals, oxides, nitrides, carbides, and chalcogenides .…”

Section: Introductionmentioning

confidence: 99%

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Agglomeration Dynamics of 1D Materials: Gas‐Phase Collision Rates of Nanotubes and Nanorods

Boies

Hoecker

Bhalerao

et al. 2019

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The agglomeration and self‐assembly of gas‐phase 1D materials in anthropogenic and natural systems dictate their resulting nanoscale morphology, multiscale hierarchy, and ultimate macroscale properties. Brownian motion induces collisions, upon which 1D materials often restructure to form bundles and can lead to aerogels. Herein, the first results of collision rates for 1D nanomaterials undergoing thermal transport are presented. The Langevin dynamic simulations of nanotube rotation and translation demonstrate that the collision kernels for rigid nanotubes or nanorods are ≈10 times greater than spherical systems. Resulting reduced order equations allow straightforward calculation of the physical parameters to determine the collision kernel for straight and curved 1D materials from 102 to 106 nm length. The collision kernels of curved 1D structures increase ≈1.3 times for long (>102 nm), and ≈5 times for short (≈102 nm) relative to rigid materials. Applications of collision frequencies allow the first kinetic analysis of aerogel self‐assembly from gas‐phase carbon nanotubes (CNTs). The timescales for CNT collision and bundle formation (0.3–42 s) agree with empirical residence times in CNT reactors (3–15 s). These results provide insights into the CNT length, number, and timescales required for aerogel formation, which bolsters our understanding of mass‐produced 1D aerogel materials.

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Section: Introductionmentioning

confidence: 99%

“…Microscopy images of 1D natural materials: a) tobacco mosaic virus, Reprinted with permission under CC BY license; b) wool, Reprinted with permission . Copyright 2008, Institute of Biopolymers and Chemical Fibres; and c) ice needles, Reproduced with permission .…”

Section: Introductionmentioning

confidence: 99%

Agglomeration Dynamics of 1D Materials: Gas‐Phase Collision Rates of Nanotubes and Nanorods

Boies

Hoecker

Bhalerao

et al. 2019

Small

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“…Recently, Liu et al have also reported that tobacco mosaic virus (TMV) short rods with ARs of 4 and 8 were internalized much faster than TMV with the AR of 17 [72]. Huang et al have also shown that the clearance rate of mesoporous silica nanoparticles (MSNs) is primarily dependent on the particle shape, where short-rod MSNs (AR 1.5, length 185 ± 22 nm) have a more rapid clearance rate than long-rod MSNs (AR 5, length 720 ± 65 nm) [64].…”

Section: Macrophage Uptake and Circulation In The Bloodmentioning

confidence: 99%

The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

Truong

Whittaker

et al. 2017

Expert Opinion on Drug Delivery

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Introduction: Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. Areas covered: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis. Expert opinion: Generally, the size, shape, and density of a particle affect its adhesion to vascular walls synergistically, and these three factors should be considered simultaneously when designing an optimal carrier for targeting CVD. Available preliminary data should encourage more studies to be conducted to investigate the use of nano-constructs, characterized by a sub-micrometer size, a non-spherical shape, and a high material density to maximize vascular wall margination and minimize capillary entrapment, as carriers for targeting CVD. ARTICLE HISTORY

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“…These results are as expected, as we and others have previously shown that TMV is internalized by cancer cells through a combination of endocytosis and macropinocytosis and that the particles then co-localize with endolysosomal markers. [28][29][30] We hypothesize that within the protease-rich environment of the endolyosome, the prodrug TMV-vcMMAE is cleaved at the protease-cleavable vc linker, resulting in release of the active MMAE component. In fact, in our previous studies, we have shown that TMV-conjugated cargos are cleaved and released in endolysosomal extracts even when conjugated via amide bonds.…”

Section: Resultsmentioning

confidence: 99%

Featured Article: Delivery of chemotherapeutic vcMMAE using tobacco mosaic virus nanoparticles

Kernan

Wen

Pitek

et al. 2017

Exp Biol Med (Maywood)

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Due to side effects associated with systemic chemotherapy, there is an urgent need for the development of novel drug delivery systems. We focus on the highaspect ratio nanotubes formed by tobacco mosaic virus (TMV) to deliver antimitotic drugs targeted to non-Hodgkin's lymphoma. Many synthetic and biologic nanocarriers are in the development pipeline; the majority of systems are spherical in shape. This may not be optimal, because high-aspect ratio filaments exhibit enhanced tumor homing, increased target cell interactions and decreased immune cell uptake, and therefore have favorable properties for drug delivery compared to their spherical counterparts. Nevertheless, the synthesis of high-aspect ratio materials at the nanoscale remains challenging; therefore, we turned toward the nucleoprotein components of TMV as a biologic nanodrug delivery system. This work presents groundwork for the development of plant virus-based vehicles for use in cancer treatment. AbstractThe first-line treatment for non-Hodgkin's lymphoma is chemotherapy. While generally well tolerated, off-target effects and chemotherapy-associated complications are still of concern. To overcome the challenges associated with systemic chemotherapy, we developed a biology-inspired, nanoparticle drug delivery system (nanoDDS) making use of the nucleoprotein components of the tobacco mosaic virus (TMV). Virus-based nanoparticles, including the high-aspect ratio soft nanorods formed by TMV, are growing in popularity as nanoDDS due to their simple genetic and chemical engineerability, size and shape tunability, and biocompatibility. In this study, we used bioconjugation to modify TMV as a multivalent carrier for delivery of the antimitotic drug valine-citrulline monomethyl auristatin E (vcMMAE) targeting non-Hodgkin's lymphoma. We demonstrate successful synthesis of the TMV-vcMMAE; data indicate that the TMV-vcMMAE particles remained structurally sound with all of the 2130 identical TMV coat proteins modified to carry the therapeutic payload vcMMAE. Cell uptake using Karpas 299 cells was confirmed with TMV particles trafficking to the endolysosomal compartment, likely allowing for protease-mediated cleavage of the valine-citrulline linker for the release of the active monomethyl auristatin E component. Indeed, effective cell killing of non-Hodgkin's lymphoma in vitro was demonstrated; TMV-vcMMAE was shown to exhibit an IC 50 of $250 nM. This study contributes to the development of viral nanoDDS.

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Size Dependent Cellular Uptake of Rod-like Bionanoparticles with Different Aspect Ratios

Cited by 95 publications

References 50 publications

Agglomeration Dynamics of 1D Materials: Gas‐Phase Collision Rates of Nanotubes and Nanorods

Agglomeration Dynamics of 1D Materials: Gas‐Phase Collision Rates of Nanotubes and Nanorods

The effects of particle size, shape, density and flow characteristics on particle margination to vascular walls in cardiovascular diseases

Featured Article: Delivery of chemotherapeutic vcMMAE using tobacco mosaic virus nanoparticles

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