Size-Dependent Absorption through Stratum Corneum by Drug-Loaded Liposomes

Liu, Junye; Zheng, Anjie; Peng, Binbin; Xu, Yongnan; Zhang, Ning

doi:10.1007/s11095-021-03079-9

Cited by 20 publications

(6 citation statements)

References 31 publications

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“…Untreated silk materials were composed of nanofibers with a length of 1–2 μm and diameter of ∼20 nm. Although SNFs had hydrophobic–hydrophilic properties that were beneficial to percutaneous absorption, nanofiber length was significantly higher than previously reported transdermal nanocarriers (<200 nm), , which caused inferior transdermal delivery. In our study, silk nanofiber length was shortened using ultrasonic treatment.…”

Section: Resultsmentioning

confidence: 59%

“…If so, the silk nanocarriers could broaden their application from cancer treatment to skin disease and cosmetic fields, strengthening their value as functional carriers. Previous studies also showed that the nanocarriers with smaller sizes exhibited better percutaneous absorption capacity. , Here, considering their similar corneum hydrophobic properties and nanosized structures, β-sheet rich silk nanoparticles of different sizes were used to improve transdermal delivery efficiency. Apart from a good loading capacity for both hydrophobic and hydrophilic drugs, silk nanoparticles had improved transdermal delivery behaviors with decreasing length.…”

Section: Introductionmentioning

confidence: 99%

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Silk Nanocarrier with Tunable Size to Improve Transdermal Capacity for Hydrophilic and Hydrophobic Drugs

Wang

Liu

et al. 2023

ACS Appl. Bio Mater.

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Transdermal drug delivery is an attractive option for multiple disease therapies as it reduces adverse reactions and improves patient compliance. Water-dispersible β-sheet rich silk nanofiber carriers have hydrophobic properties that benefit transdermal delivery but still show inferior transdermal capacities. Thus, hydrophobic silk nanofibers were fabricated to fine-tune their size and endow them with desirable transdermal delivery capacities. Silk nanocarrier length was shortened from 2000 nm to approximately 40 nm after ultrasonic treatment. In vitro human skin and in vivo animal studies revealed different transdermal behaviors for silk nanocarriers at different nanosizes. Silk nanocarriers passed slowly through the corneum without destroying the corneum structure. Improved transdermal capacity was achieved for smaller size carriers. Both hydrophilic and hydrophobic drugs could be loaded onto silk nanocarriers, suggesting a promising future for different disease therapies. No cytotoxicity and skin irritation were identified for silk nanocarriers, which strengthened their superiority as transdermal carriers. Therefore, silk nanocarriers <100 nm may promote the percutaneous absorption of active cargos for disease therapy and cosmetic applications.

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Section: Resultsmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Silk Nanocarrier with Tunable Size to Improve Transdermal Capacity for Hydrophilic and Hydrophobic Drugs

Wang

Liu

et al. 2023

ACS Appl. Bio Mater.

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“…RA incorporation into nanovesicles such as liposomes is proven to ameliorate the absorption into the skin. 45 Our in vivo study found that the topical application of multifunctional liposomes (NV/PK/SME) led to the keratinization normalization and disintegrated barrier recovery in the C. acnes-infected mice. The bacterial invasion in the skin was also reduced after topical liposome application.…”

Section: Dovepressmentioning

confidence: 73%

Proteinase K/Retinoic Acid-Loaded Cationic Liposomes as Multifunctional Anti-Acne Therapy to Disorganize Biofilm and Regulate Keratinocyte Proliferation

Tsai¹,

Lin²,

Trousil³

et al. 2023

IJN

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Background: Simultaneous anti-Cutibacterium acnes and anti-inflammatory actions are highly beneficial in treating acne vulgaris. In this study, we present novel anti-acne nanovesicles based on liposomes loaded with proteinase K (PK), retinoic acid (RA), and soyaethyl morpholinium ethosulfate (SME) to achieve an effective and safe treatment. Materials and Methods: This study examined in vitro planktonic and biofilm C. acnes elimination, as well as the keratinocyte proliferation suppression by liposomes. The multifunctional liposomes for treating C. acnes in mice were also evaluated. Results:We acquired multifunctional liposomes with a size of 71 nm and zeta potential of 31 mV. The antimicrobial activity of SME was enhanced after liposomal encapsulation according to the reduction of minimum bactericidal concentration (MBC) by 6-fold. The multifunctional liposomes exhibited a synergistically inhibitory effect on biofilm C. acnes colonization compared with the liposomes containing PK or those containing SME individually. The adhesive bacterial colony in the microplate was lessened by 62% after multifunctional liposome intervention. All liposomal formulations tested here demonstrated no cytotoxicity against the normal keratinocytes but inhibited C. acnes-stimulated cell hyperproliferation. The in vitro scratch assay indicated that the liposomal RAbut not free RA-restrained keratinocyte migration. The animal study showed that free RA combined with SME and multifunctional nanovesicles had a similar effect on diminishing C. acnes colonies in the skin. On the other hand, liposomes exhibited superior performance in recovering the impaired skin barrier function than the free control. We also found that RA-loaded nanovesicles had greater skin tolerability than free RA. Conclusion:The cationic liposomes containing dual PK and RA represented a potential treatment to arrest bacterial infection and associated inflammation in acne.

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“…A nanoparticle’s behavior is governed by both its structural and chemical properties, with particle size being among the most important properties that determine targeting ability, cell uptake, and drug release. Although dependent on the material for skin-related drug delivery, smaller nanoparticles have, in general, exhibited higher cell uptake and deeper penetration compared to larger microparticles, leading to faster drug release and wider drug distribution [ 118 , 119 ].…”

Section: Particulate Drug Delivery Systems In Wound and Skin Regenera...mentioning

confidence: 99%

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

Bernardes,

Veiga,

Barros

et al. 2024

IJMS

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The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.

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Size-Dependent Absorption through Stratum Corneum by Drug-Loaded Liposomes

Cited by 20 publications

References 31 publications

Silk Nanocarrier with Tunable Size to Improve Transdermal Capacity for Hydrophilic and Hydrophobic Drugs

Silk Nanocarrier with Tunable Size to Improve Transdermal Capacity for Hydrophilic and Hydrophobic Drugs

Proteinase K/Retinoic Acid-Loaded Cationic Liposomes as Multifunctional Anti-Acne Therapy to Disorganize Biofilm and Regulate Keratinocyte Proliferation

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

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