Size-controlled magnetoliposomes with tunable magnetic resonance relaxation enhancements

Meledandri, Carla J.; Ninjbadgar, Tsedev; Brougham, Dermot F.

doi:10.1039/c0jm01061h

Cited by 27 publications

(31 citation statements)

References 48 publications

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“…This finding is in accordance with previous studies showing that the size of magnetic nanoliposomes is an important factor for their in vitro and in vivo distributions, pharmacodynamics and effectiveness [27]. …”

Section: Discussionsupporting

confidence: 93%

Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin

et al. 2014

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BackgroundArtemisinin is the major sesquiterpene lactones in sweet wormwood (Artemisia annua L.), and its combination with transferrin exhibits versatile anti-cancer activities. Their non-selective targeting for cancer cells, however, limits their application. The aim of this study was to prepare the artemisinin and transferrin-loaded magnetic nanoliposomes in thermosensitive and non-thermosensitive forms and evaluate their antiproliferative activity against MCF-7 and MDA-MB-231 cells for better tumor-targeted therapy.MethodsArtemisinin and transferrin-loaded magnetic nanoliposomes was prepared by extrusion method using various concentrations of lipids. These formulations were characterized for particle size, zeta potential, polydispersity index and shape morphology. The artemisinin and transferrin-loading efficiencies were determined using HPLC. The content of magnetic iron oxide in the nanoliposomes was analysed by spectrophotometry. The in vitro release of artemisinin, transferrin and magnetic iron oxide from vesicles was assessed by keeping of the nanoliposomes at 37°C for 12 h. The in vitro cytotoxicity of prepared nanoliposomes was investigated against MCF-7 and MDA-MB-231 cells using MTT assay.ResultsThe entrapment efficiencies of artemisinin, transferrin and magnetic iron oxide in the non-thermosensitive nanoliposomes were 89.11% ± 0.23, 85.09% ± 0.31 and 78.10% ± 0.24, respectively. Moreover, the thermosensitive formulation showed a suitable condition for thermal drug release at 42°C and exhibited high antiproliferative activity against MCF-7 and MDA-MB-231 cells in the presence of a magnetic field.ConclusionsOur results showed that the thermosensitive artemisinin and transferrin-loaded magnetic nanoliposomes would be an effective choice for tumor-targeted therapy, due to its suitable stability and high effectiveness.

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Section: Discussionsupporting

confidence: 93%

Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin

et al. 2014

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“…We have recently observed similar behaviour for densely packed quasi-spherical clusters of lipid stabilised Fe 3 O 4 nanoparticles. [19] Those findings are included in Figure 2 b. It can be seen that the slopes of the lines are similar in all cases.…”

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confidence: 52%

“…For CoFe 2 O 4 ·PSSS, the same r 1 scaling is obtained, despite the fact that the relaxation is non-superparamagnetic. The r 1 behaviour can be explained by the larger nanocomposites having a lower surface area to [19] volume ratio, leaving fewer nanoparticles accessible to the surface. These two studies demonstrate that r 1 is limited by the hydrodynamic surface area for a range of nanocomposites.…”

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confidence: 97%

NMR Relaxation of Water in Nanostructures: Analysis of Ferromagnetic Cobalt-Ferrite Polyelectrolyte Nanocomposites

et al. 2011

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“…21 The resulting DMLs were then washed and purified with pure water by centrifugation in order to preserve their structure. First, 15 mL of the NiFe 2 O 4 NPs aqueous dispersion previously obtained was diluted with 3 mL of water and centrifuged.…”

Section: Preparation Of Magnetoliposomesmentioning

confidence: 99%

Magnetic liposomes based on nickel ferrite nanoparticles for biomedical applications

Rodrigues

Gomes

Almeida

et al. 2015

Phys. Chem. Chem. Phys.

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Nickel ferrite nanoparticles with superparamagnetic behavior at room temperature were synthesized using a coprecipitation method. These magnetic nanoparticles were either covered with a lipid bilayer, forming dry magnetic liposomes (DMLs), or entrapped in liposomes, originating aqueous magnetoliposomes (AMLs). A new and promising method for the synthesis of DMLs is described. The presence of the lipid bilayer in DMLs was confirmed by FRET (Förster Resonance Energy Transfer) measurements between the fluorescent-labeled lipids NBD-C12-HPC (NBD acting as a donor) included in the second lipid layer and rhodamine B-DOPE (acceptor) in the first lipid layer. An average donor-acceptor distance of 3 nm was estimated. Assays of the non-specific interactions of magnetoliposomes with biological membranes (modeled using giant unilamellar vesicles, GUVs) were performed. Membrane fusion between both aqueous and dry magnetoliposomes and GUVs was confirmed by FRET, which is an important result regarding applications of these systems both as hyperthermia agents and antitumor drug nanocarriers.

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Size-controlled magnetoliposomes with tunable magnetic resonance relaxation enhancements

Cited by 27 publications

References 48 publications

Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin

Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin

NMR Relaxation of Water in Nanostructures: Analysis of Ferromagnetic Cobalt-Ferrite Polyelectrolyte Nanocomposites

Magnetic liposomes based on nickel ferrite nanoparticles for biomedical applications

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