Size‐controllable synthesis of polymeric iodine‐carrying nanoparticles for medical CT imaging

Illert, Patrick; Wängler, Björn; Wängler, Carmen; Röder, Thorsten

doi:10.1002/pat.4043

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…For instance, the circulation half‐life of nanoparticles was 15 h, while that of iodinated small molecules was only minutes . Patrick et al have developed contrast agents based on nanoparticles containing iodine and poly(2‐methacryloyloxyethyl (2,3,5‐triiodobenzoate) (PMAOETIB), using microemulsion polymerization . PMAOETIB consisted of non‐soluble, iodine‐carrying particles that circulated in the blood after being intravenously injected.…”

Section: Pharmacological Nanoparticles From Emulsion Techniquesmentioning

confidence: 99%

“…[92] Patrick et al have developed contrast agents based on nanoparticles containing iodine and poly(2methacryloylox yethyl (2,3,5triiodobenzoate) (PMAOETIB), using microemul sion polymerization. [93] PMAOETIB consisted of nonsoluble, iodinecarrying particles that circulated in the blood after being intravenously injected. Different surfactants such as cationic surfactants (cetyltrimethylammonium bromide and cetyltri methylammonium chloride) and anionic surfactants (sodium oleate and sodium dodecyl sulfate) were used to control the particle size of these iodinecarrying nanoparticles which were ranging from 30 to 930 nm.…”

Section: Computed Tomographymentioning

confidence: 99%

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Emulsion Techniques for the Production of Pharmacological Nanoparticles

Jenjob

Phakkeeree

Seidi

et al. 2019

Macromolecular Bioscience

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Nanoparticles have the advantages over micron‐sized particles to typically provide higher intracellular uptake and drug bioavailability. Emulsion techniques are commonly used methods for producing nanoparticles aiming at high encapsulation efficiency, high stability, and low toxicity. Here, the recent developments of nanoparticles prepared from emulsions, the synthesis of nanoparticles, their physicochemical properties, and their biomedical applications are discussed. Selection of techniques, such as emulsion polymerization, miniemulsion polymerization, microemulsion polymerization, and emulsion‐solvent evaporation processes, strongly influences morphologies, size distributions, and particle properties. Details in the synthetic strategies governing the performance of nanoparticles in bioimaging, biosensing, and drug delivery are presented. Benefits and limitations of molecular imaging techniques are also discussed.

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Section: Pharmacological Nanoparticles From Emulsion Techniquesmentioning

confidence: 99%

Section: Computed Tomographymentioning

confidence: 99%

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Jenjob

Phakkeeree

Seidi

et al. 2019

Macromolecular Bioscience

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“…In our previous work, we synthesized polyMAOETIB particles (without Fe 3 O 4 ) with defined particle sizes using microemulsion polymerization and various surfactants. The size of the particles was uniform and able to be adjusted from 30 to 930 nm with good reproducibility …”

Section: Introductionmentioning

confidence: 99%

Functionalizable composite nanoparticles as a dual magnetic resonance imaging/computed tomography contrast agent for medical imaging

Illert

Wängler

et al. 2019

J of Applied Polymer Sci

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A dual contrast agent for computed tomography (CT) and magnetic resonance imaging (MRI) was synthesized via microemulsion polymerization. This contrast agent consists of Fe3O4 particles (d = 7 nm) with an iodine‐carrying nanopolymeric shell, with overall particle sizes ranging from 50 to 250 nm. 2‐Methacryloyloxyethyl(2,3,5‐triiodobenzoate) was used as the monomer. Sodium oleate was used as the surfactant and its amount was varied to control the overall particle size. The composite nanoparticles were mainly characterized via dynamic light scattering, with further analyses using transmission electron microscopy and atomic force microscopy. The particles provided a highly visible contrast in CT and MR images. A template for biomedical applications was created by adding a comonomer and the particles were further functionalized with the somatostatin analogue Tyr3‐octreotate. The particles were tested for specific uptake into somatostatin receptor‐positive AR42J cells. The additional uptake of the functionalized particles was investigated. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47571.

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Microemulsion Polymerization

Demirci¹,

Şahiner²

2019

Encyclopedia of Polymer Science and Technology

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In this article, recent developments in microemulsion polymerization for polymeric particles preparation are summarized. Polymeric particles with hydrophilic, hydrophobic, and amphiphilic nature can be synthesized by means of microemulsion polymerization employing different formulations. The types, the amounts, and the nature of the used surfactant, solvent, and cosolvent (if any); mixing rate; temperature; the types and the amounts of cross‐linkers (if any); and the nature of monomers and polymers are very important parameters in microemulsion polymerization determining the size and the properties of polymeric particles. These parameters that are effective in the compartmentalization of the reaction medium and their effect on size of the prepared particles are summarized.

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Size‐controllable synthesis of polymeric iodine‐carrying nanoparticles for medical CT imaging

Cited by 5 publications

References 24 publications

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Emulsion Techniques for the Production of Pharmacological Nanoparticles

Functionalizable composite nanoparticles as a dual magnetic resonance imaging/computed tomography contrast agent for medical imaging

Microemulsion Polymerization

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