Size controllable one step synthesis of gold nanoparticles using carboxymethyl chitosan

Sun, Lixin; Pu, Shuai; Li, Jin; Cai, Jun; Zhou, Bingshuang; Ren, Guohui; Ma, Qiang; Zhong, Lei

doi:10.1016/j.ijbiomac.2018.11.006

Cited by 29 publications

(10 citation statements)

References 80 publications

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“…As a result, the charge density of chitosan was decreased, leading to the conformation contraction of chitosan chain and size reduction of the NPs. 31–33…”

Section: Resultsmentioning

confidence: 99%

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

Cheng

Wei

et al. 2020

J Biomater Appl

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In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a narrow distribution. The size of the Au@CS-PMPC NPs, as well as the size of the embedded gold NPs, might be well-controlled by adjusting the feeding ratio between chitosan and HAuCl4. Furthermore, the Au@CS-PMPC NPs showed increased colloidal stability, high drug loading content, pH-responsive drug release, excellent biocompatibility and bright fluorescence emission. The results demonstrated that Au@CS-PMPC NPs showed a great potential for tumor therapy via the combination advantages of pH-sensitive controlled drug release and cellular fluorescence imaging.

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“…As a result, the charge density of chitosan was decreased, leading to the conformation contraction of chitosan chain and size reduction of the NPs. 31–33…”

Section: Resultsmentioning

confidence: 99%

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

Cheng

Wei

et al. 2020

J Biomater Appl

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“…These authors indicated that the required dose for completely reducing 1 mM [Au 3+ ] in Au 3+ /dextran solution by gamma-ray irradiation was 6 kGy. Sun et al [23] also informed that CM-chitosan at a concentration of 0.3-0.45% could be used as dual roles of the reducing agent and stabilizer for synthesizing AuNPs, while Ibrahim et al [24] successfully prepared electrospun nanofibers containing AuNPs using 2% CM-chitosan. In this study, solutions with different concentrations of 0.5, 1.0, and 1.5 mM [Au 3+ ] stabilized in 0.5% CM-chitosan were irradiated by gamma-rays at doses in the range of 2-10 kGy for the synthesis of AuNPs.…”

Section: Radiation Synthesis and Characterization Of Aunpsmentioning

confidence: 99%

“…Therefore, CM-chitosan is attracting increasing interest for use in applications in the biomedical and pharmaceutical fields [20]. Although CM-chitosan was reported to have several unique biological properties and has been used for stabilizing AuNPs synthesized by chemical reduction, heating, or UV-light irradiation methods [21][22][23][24], research on the synthesis of AuNPs by gamma irradiation using CM-chitosan as a stabilizer has not been carried out thus far.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Carboxymethyl Chitosan-Capped Gold Nanoparticles by Gamma Irradiation with Novel Potential Applications as Antioxidant, Hepatoprotective, and Anticancer Substance

Linh

Nghĩa²,

Vu³

et al. 2021

Journal of Nanomaterials

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Gold nanoparticles capped by carboxymethyl chitosan (AuNPs/CM-chitosan) with particle sizes of 5.2–7.3 nm were successfully synthesized by the γ-irradiation of Au3+ solutions. Their characteristics were analysed by transmission electron microscope images, powder X-ray diffraction patterns, UV-visible spectroscopy, and Fourier transform infrared spectra. The antioxidant activity of AuNP/CM-chitosan was time dependent and much higher than that of ascorbic acid at the same concentration. On the other hand, the results of tail vein injection of AuNP/CM-chitosan in mice indicated that this product was not toxic to mice and that AuNPs were mainly distributed in liver tissue, at approximately 77.5%, 6 h after injection. The hepatoprotective activity of AuNP/CM-chitosan was also tested in acetaminophen-induced hepatotoxic mice by oral administration at daily doses of 0.5–2 mg/head. The results indicated that compared to the control, supplementation with 2 mg of AuNPs/head strongly reduced the aspartate aminotransferase and alanine aminotransferase indexes in the blood of the tested mice by approximately 66.5 and 69.3%, respectively. Furthermore, the MTT (3[4,5 dimetylthiazol-2-yl]-2,5-diphenyltetrazol bromide) assay on a liver cancer cell line (HepG2) clearly confirmed strong anticancer activity on HepG2 cells treated with 0.05–0.5 mM AuNPs and the tested cells did not survive after treatment with 0.5 mM AuNPs, while the growth of the normal cell line (L929) has no significant effect at the same treated concentration of AuNPs. The AuNP/CM-chitosan in the present study was synthesized by the γ-irradiation method without using any toxic-reducing chemical and stabilized in a natural biocompatible polymer. The strong antioxidant, hepatoprotective, and anticancer effects of this product may be supported to be used in the biomedical field.

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“…Among the broad diversity of nanohybrids (NHs), gold nanohybrids (GNHs) have recently been emerging as promising drug delivery applications for the loading and releasing of drugs [ 27 , 28 ]. GNHs offer better benefits than other metallic NHs because they are inert, non-toxic, and highly biocompatible while concurrently offering unique physicochemical properties [ 29 , 30 ]. In addition, the surface of GNHs can be easily tuned to bind with drugs, and their particle size is easily controlled during preparation by different synthetic methods [ 24 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Targeted Gold Nanohybrids Functionalized with Folate-Hydrophobic-Quaternized Pullulan Delivering Camptothecin for Enhancing Hydrophobic Anticancer Drug Efficacy

Laksee¹,

Supachettapun

Muangsin

et al. 2021

Polymers

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This study presented a green, facile and efficient approach for a new combination of targeted gold nanohybrids functionalized with folate-hydrophobic-quaternized pullulan delivering hydrophobic camptothecin (CPT-GNHs@FHQ-PUL) to enhance the efficacy, selectivity, and safety of these systems. New formulations of spherical CPT-GNHs@FHQ-PUL obtained by bio-inspired strategy were fully characterized by TEM, EDS, DLS, zeta-potential, UV-vis, XRD, and ATR-FTIR analyses, showing a homogeneous particles size with an average size of approximately 10.97 ± 2.29 nm. CPT was successfully loaded on multifunctional GNHs@FHQ-PUL via intermolecular interactions. Moreover, pH-responsive CPT release from newly formulated-CPT-GNHs@FHQ-PUL exhibited a faster release rate under acidic conditions. The intelligent CPT-GNHs@FHQ-PUL (IC50 = 6.2 μM) displayed a 2.82-time higher cytotoxicity against human lung cancer cells (Chago-k1) than CPT alone (IC50 = 2.2 μM), while simultaneously exhibiting less toxicity toward normal human lung cells (Wi-38). These systems also showed specific uptake by folate receptor-mediated endocytosis, exhibited excellent anticancer activity, induced the death of cells by increasing apoptosis pathway (13.97%), and arrested the cell cycle at the G0-G1 phase. The results of this study showed that the delivery of CPT by smart GNHs@FHQ-PUL systems proved to be a promising strategy for increasing its chemotherapeutic effects.

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Size controllable one step synthesis of gold nanoparticles using carboxymethyl chitosan

Cited by 29 publications

References 80 publications

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging

Synthesis of Carboxymethyl Chitosan-Capped Gold Nanoparticles by Gamma Irradiation with Novel Potential Applications as Antioxidant, Hepatoprotective, and Anticancer Substance

Targeted Gold Nanohybrids Functionalized with Folate-Hydrophobic-Quaternized Pullulan Delivering Camptothecin for Enhancing Hydrophobic Anticancer Drug Efficacy

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