Size at birth and plasma insulin-like growth factor-1 concentrations.

Fall, Caroline; Pandit, Anand; Law, Catherine; Yajnik, Chittaranjan S.; Clark, P.; Breier, Bernhard H.; Osmond, Clive; Shiell, A. W.; Gluckman, P. D.; Barker, D. J. P.

doi:10.1136/adc.73.4.287

Cited by 198 publications

(114 citation statements)

References 48 publications

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“…Associations between height and IGF-I levels in childhood are relatively strong (Fall et al, 1995), whereas studies in adults, including data from Boyd Orr, suggest they are weak and inconsistent (GoodmanGruen and Barrett-Connor, 1997;Chan et al, 1998;Gunnell et al, 2004;Bray et al, 2006). This indicates that it is IGF-I levels in childhood, but not adulthood, that may explain height-cancer and height-coronary heart disease associations.…”

Section: Discussionmentioning

confidence: 69%

Childhood diet and insulin-like growth factors in adulthood: 65-year follow-up of the Boyd Orr Cohort

et al. 2007

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Objective: High levels of insulin-like growth factor-I (IGF-I) are associated with an increased cancer risk and reduce risk of diabetes and coronary heart disease. We investigated associations of diet in childhood, in particular energy intake, with the IGF system in adulthood to determine if IGF-I -disease associations could be linked to early nutrition. Design: Retrospective cohort study. Setting: Sixteen survey centres in England and Scotland that originally participated in the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-War Britain, 1937-1939. Subjects: Seven hundred and twenty-eight participants (679 with complete data) in the Boyd Orr cohort. Methods: Participants were originally surveyed between 1937 and 1939 (at median age 5.8 years; inter-quartile range: 2.9-9.6) and were followed up for 65 years. Dietary exposure in childhood was assessed from 7-day household food inventories. Outcomes are expressed as regression coefficients for the change in IGF per standard deviation increased childhood nutrient or food intake, as derived from levels of household consumption. Results: In fully-adjusted models, energy-rich family diets in childhood were not associated with IGF-I (regression coefficient: 0.9 ng/ml; 95% confidence interval (CI): À1.8, 3.7), IGF-II, IGF binding proteins (IGFBP)-2 or IGFBP-3 in adulthood. IGF-I was associated inversely with childhood family-diets high in milk (À2.5 ng/ml; À5.1, 0.1; P ¼ 0.05) and positively with vegetable-rich diets (3.5 ng/ml; 0.9, 6.1; P ¼ 0.009). IGF-I was not associated with family diets rich in protein, carbohydrates, fats, calcium, meat or fruit. IGF-II, IGFBP-2 and IGFBP-3 were not related to childhood family diet. Conclusions: This study suggests that energy-rich family diets in childhood do not program the IGF system in adulthood. As childhood diet was based on household consumption, however, measurement error may obscure individual-level diet-IGF associations. The associations of milk-and vegetable-rich family diets in childhood with IGF-I could be chance findings, but nevertheless are consistent with recent publications and warrant further investigation.

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Section: Discussionmentioning

confidence: 69%

Childhood diet and insulin-like growth factors in adulthood: 65-year follow-up of the Boyd Orr Cohort

et al. 2007

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“…Fetal exposure to glucocorticoids increases the sensitivity of the arterial walls to angiotensin II and also predisposes the fetus to higher levels of blood pressure (27,28). The "catch up" growth after birth resets the hypothalamus-pituitary axis, leading to an increase in growth factors such as insulin-like growth factor-1 (IGF-1), that may lead to the development of hypertension and insulin resistance (29,30). In our study, SBP showed a stronger relationship with WBWR than with weight.…”

Section: Discussionmentioning

confidence: 99%

Lower Birth Weight Associated with Current Overweight Status Is Related with the Metabolic Syndrome in Obese Japanese Children

et al. 2007

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The purpose of this study was to clarify the relationship between lower birth weight and current overweight status and to examine the involvement of these factors in the development of the metabolic syndrome (MS) in obese Japanese children. We examined 97 obese boys (mean age 11.3 years; mean percentage overweight [POW] 52.4%) and 29 obese girls (mean age 11.1 years; mean POW 58.3%). The anthropometric measurements, blood pressure, fasting serum insulin and blood glucose, liver enzymes, lipids and lipoproteins were measured. Birth weight and gestational weeks were also recorded. The subjects were divided into either an MS group or a Non-MS group using criteria proposed for Japanese children. We compared the weight parameters (birth weight, current weight and current weight-to-birth weight ratio [WBWR]) between the two groups and analyzed the relationships between the weight parameters and metabolic derangements.There were no significant differences in age or anthropometric measurements between the two groups.However, birth weight in the MS group was lower than that in the Non-MS group, while WBWR of the MS group was higher than that in the Non-MS group. Blood pressure and serum insulin correlated positively with WBWR. These findings suggested that lower birth weight with current overweight status was associated with the MS in obese Japanese children. We were unable to clarify whether subjects with lower birth weight who achieved proper weight gains had the same risk as subjects with appropriate birth weight. However, they should be assisted to grow adequately to prevent future metabolic derangements. (Hypertens Res 2007; 30: 627-634)

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“…It has been suggested that larger birth size may indicate a greater number of cells at risk of carcinogenesis, e.g., for breast cancer or kidney cancer. Programming of the insulin-like growth factor (IGF) system in utero may lead to increased postnatal cell proliferation rates, 33 and IGF-1 has been linked to an increased risk of breast 34 and other epithelial cancers. 35 We were not able to investigate other features of the growth trajectory, such as postnatal catch-up growth.…”

Section: Biologic Plausibilitymentioning

confidence: 99%

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

McCormack

dos‐Santos‐Silva

Koupil

et al. 2005

Intl Journal of Cancer

120

114

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Associations between larger size at birth and increased rates of adult cancer have been proposed but few empirical studies have examined this hypothesis. We investigated overall and site-specific cancer incidence in relation to birth characteristics in a Swedish population-based cohort of 11,166 singletons born in 1915-1929 for whom we have detailed obstetric data and who were alive in 1960. A total of 2,685 first primary cancers were registered during follow-up from 1960 to 2001. A standard deviation (SD) increase in birth weight for gestational age (GA) was associated with (sexadjusted) increases of 13% (95% CI = 0.03-0.23) in the rates of digestive cancers and of 17% (95% CI = 0.01-0.35) in the rates of lymphatic cancers. Women who had higher birth weights also had increased rates of breast cancer under age 50 years (by 39% per SD increase; 95% CI = 0.09-0.79), but reduced rates (by 24%; 95% CI = 0.07-0.38) of endometrial (corpus uteri) cancer at all ages. There was no evidence of associations with other cancer sites. For overall cancer incidence, men had an 8% increased risk at all ages per SD increase in birth weight for GA while women only had an increased risk under age 50 years (mainly driven by the association with breast cancer). These findings provide evidence of a modest association of birth size and adult cancer risk, resulting from positive associations with a few cancer sites and a possible inverse association with endometrial cancer. ' 2005 Wiley-Liss, Inc.

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Size at birth and plasma insulin-like growth factor-1 concentrations.

Cited by 198 publications

References 48 publications

Childhood diet and insulin-like growth factors in adulthood: 65-year follow-up of the Boyd Orr Cohort

Childhood diet and insulin-like growth factors in adulthood: 65-year follow-up of the Boyd Orr Cohort

Lower Birth Weight Associated with Current Overweight Status Is Related with the Metabolic Syndrome in Obese Japanese Children

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

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