Sixty-Day Outcomes Among Patients Hospitalized With COVID-19

Chopra, Vineet; Flanders, Scott A.; O’Malley, Megan; Malani, Anurag N.; Prescott, Hallie C.

doi:10.7326/m20-5661

Cited by 530 publications

(564 citation statements)

References 4 publications

(2 reference statements)

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“…We found that nearly 1 in 10 patients with COVID-19 were readmitted within 30 days, which is consistent with reports from the US. 3,50 Compared with patients with influenza, patients with COVID-19 were more likely to be male and reside in long-term care, which is consistent with evidence that COVID-19 affects men more severely 51 and has burdened long-term care facilities in Ontario. 43,52 Patients from neighbourhoods with lower income were overrepresented in both the COVID-19 and influenza groups, reminding us that the socioeconomic gradients in COVID-19 53 are emblematic of those that exist for many diseases, including influenza.…”

Section: Discussionsupporting

confidence: 73%

“…6,7 We extend this literature by including patients who did not require admission to the ICU, finding that about one-quarter of all patients admitted to hospital for COVID-19, and one-fifth of those admitted through the emergency department, used the ICU. In the global context, patients with COVID-19 in Ontario (median age 65 yr) were somewhat older than patients in China (median 51-56 yr) 5,46 and the US (median 62-63 yr), [1][2][3] and were younger than those in the UK (median 73 yr), 4 but mortality and ICU use were generally similar. We found that nearly 1 in 10 patients with COVID-19 were readmitted within 30 days, which is consistent with reports from the US.…”

Section: Discussionmentioning

confidence: 92%

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Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area

Verma

Hora

Jung

et al. 2021

CMAJ

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I nternational studies report that patients admitted to hospital with coronavirus disease 2019 (COVID-19) have high rates of critical illness and mortality. 1-5 Two small Canadian case series have described care for critically ill patients with COVID-19 and found mortality rates of up to 25%. 6,7 However, outcomes of patients admitted to hospital for COVID-19 in Canada are not well described, particularly outside of intensive care units (ICUs). Case fatality rates for COVID-19 vary dramatically worldwide, 8 and outcomes of patients admitted to hospital for COVID-19 in Canada may differ from other countries because of differences in populations, public health and health care systems. Seasonal influenza is a useful comparator for COVID-19 9-11 as it is another respiratory virus, familiar to the general public, with high rates of morbidity and mortality. The purpose of this study was to describe patient characteristics, resource use, clinical care and outcomes for patients admitted to hospital with COVID-19 in Ontario, Canada, using influenza as a comparator. We also validated the performance of various prognostic risk scores for in-hospital mortality among patients with COVID-19.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 92%

Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area

Verma

Hora

Jung

et al. 2021

CMAJ

View full text Add to dashboard Cite

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“…Centers should anticipate a growing population of survivors of COVID-19–related critical illness as the pandemic continues ( 26 ). In our study, 68.8% of survivors received post–acute care services (75.6% if hospice discharges are included), and among at-risk survivors (that is, those not discharged to hospice), all-cause 30-day rehospitalization was relatively uncommon, at 10.8%.…”

Section: Discussionmentioning

confidence: 99%

Characteristics, Outcomes, and Trends of Patients With COVID-19–Related Critical Illness at a Learning Health System in the United States

et al. 2021

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“…In this study we were only able to evaluate in-hospital mortality, and thus the mortality estimates do not include deaths that occurred after hospital discharge. This is important to note, since in a study of 1,648 patients hospitalized with COVID-19 in Michigan (March 16-July 1, 2020), 6.7% of all patients discharged died during 60 days of follow-up[28]. Further studies are needed to better understand the outcomes of COVID-19 patients discharged from the hospital, including re-hospitalizations, delayed mortality, and longterm sequelae.Among the hospitalized COVID-19 patients in this study, the median hospital LOS was 5 days, which substantially increased with ICU admission and IMV usage (up to a median of 15 days), and also by age (up to a median of 6 days among those 50 years of age and older).…”

mentioning

confidence: 99%

Health outcomes and economic burden of hospitalized COVID-19 patients in the United States

Fusco

Shea

Lin³

et al. 2021

Journal of Medical Economics

147

129

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Objective: To evaluate health outcomes and the economic burden of hospitalized COVID-19 patients in the United States. Methods: Hospitalized patients with a primary or secondary discharge diagnosis code for COVID-19 (ICD-10 code U07.1) from April 1-October 31, 2020 were identified in the Premier Healthcare COVID-19 Database. Patient demographics, hospitalization characteristics, and concomitant medical conditions were assessed. Hospital length of stay (LOS), in-hospital mortality, hospital charges, and hospital costs were evaluated overall and stratified by age groups, insurance types, and 4 COVID-19 disease progression states based on intensive care unit (ICU) and invasive mechanical ventilation (IMV) usage. Results: Of the 173,942 hospitalized COVID-19 patients, median age was 63 years, 51.0% were male, and 48.5% were covered by Medicare. The most prevalent concomitant medical conditions were cardiovascular disease (73.5%), hypertension (64.8%), diabetes (40.7%), obesity (27.0%), and chronic kidney disease (24.2%). Approximately one-fifth (21.9%) of the hospitalized COVID-19 patients were admitted to the ICU and 16.9% received IMV; most patients (73.6%) did not require ICU admission or IMV, and 12.4% required both. The median hospital LOS was 5 days, in-hospital mortality was 13.6%, median hospital charges were $43,986, and median hospital costs were $12,046. Hospital LOS and in-hospital mortality increased with ICU and/or IMV usage and age; hospital charges and costs increased with ICU and/or IMV usage. Patients with both ICU and IMV usage had the longest median hospital LOS (15 days), highest inhospital mortality (53.8%), and highest hospital charges ($198,394) and hospital costs ($54,402). Limitations: This retrospective administrative database analysis relied on coding accuracy and a subset of admissions with validated/reconciled hospital costs. Conclusions: This study summarizes the severe health outcomes and substantial hospital costs of hospitalized COVID-19 patients in the US. The findings support the urgent need for rapid implementation of effective interventions, including safe and efficacious vaccines.

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Sixty-Day Outcomes Among Patients Hospitalized With COVID-19

Cited by 530 publications

References 4 publications

Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area

Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area

Characteristics, Outcomes, and Trends of Patients With COVID-19–Related Critical Illness at a Learning Health System in the United States

Health outcomes and economic burden of hospitalized COVID-19 patients in the United States

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