Sixty cases of extreme osteonecrosis and osteomyelitis of the mandible and maxilla in a West African population

Khullar, Shelley M.; Tvedt, D.; Chapman, Kenneth E.; Herlofson, Bente Brokstad

doi:10.1016/j.ijom.2012.04.022

Cited by 31 publications

(26 citation statements)

References 32 publications

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“…The systemic use of SA has been reported in research 46 focusing primarily on its adverse effects, including esophagitis, gastric ulcers, and osteonecrosis of the jaw. These adverse effects are more common in patients who have received high doses for long periods; the use of low doses, especially when the compound is applied topically, has not shown this association 47 …”

Section: Discussionmentioning

confidence: 99%

Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats

Almeida

Ervolino

Novaes

et al. 2015

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats

Almeida

Ervolino

Novaes

et al. 2015

Journal of Periodontology

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“…In more recent times, Kullar et al . reported 60 cases of extreme osteonecrosis and osteomyelitis of the mandible and maxilla in a West African population. This case series showed significant mandibular and maxillary segments exfoliating with one particular case of total hard palate exfoliation as a single unit.…”

Section: Discussionmentioning

confidence: 77%

Severe osteonecrosis of the jaw with attempted near total mandibular exfoliation

et al. 2018

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This report describes an unusual and extreme case of osteonecrosis of the jaw (ONJ) affecting the entire mandible, which was attempting to self exfoliate. A 76‐year old male presented clinically with all aspects of the mandible, except the condylar heads, necrotic and exposed in the oral cavity. The mandible had elevated out of the mucosa and was attempting to exfoliate through the mouth. As it was obstructing his oral cavity, the necrotic mandible was sectioned posteriorly allowing the patient to speak and eat comfortably, as well regain an oral seal. The use of intravenous bisphosphonates for metastatic prostate cancer coupled glucocorticosteroids, diabetes mellitus and hyperlipidaemia are likely to have contributed this extensive medication related ONJ. This complication is well‐recognised in association with bisphosphonates, however, this case is unique due to its severity, its spontaneous occurrence and the oral cavity's natural response to manage it, through near complete self exfoliation.

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“…[17] In another review of osteomyelitis of the jaw in West African population, Khullar et al . [18] found only six cases of osteomyelitis of maxilla out of the total 60 cases of osteomyelitis involving both jaw bones (maxilla and mandible). They ascribed various factors such as genetic, toxic and environmental apart from the infective etiology.…”

Section: Discussionmentioning

confidence: 99%

Infantile maxillary sinus osteomyelitis mimicking orbital cellulitis

Nagarajan

Nathan

Panchanathan

et al. 2014

J Global Infect Dis

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Periorbital soft tissue swelling may result due to primary orbital pathology or from adjacent facio-maxillary or sino-nasal inflammatory causes. Osteomyelitis of maxilla in the pediatric age group is a rare entity in this era of antibiotics. We present an 11-month-old female infant who was brought with peri-orbital selling and purulent nasal discharge. Computed Tomography showed erosions of the walls of maxillary sinus suggestive of osteomyelitis. Culture of sinus scraping showed Staphylococcus aureus growth and the child improved with intravenous cloxacillin therapy. This case is presented due to the rarity of its presentation in this age group and for awareness to consider this entity in children having fever and peri-orbital swelling.

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Sixty cases of extreme osteonecrosis and osteomyelitis of the mandible and maxilla in a West African population

Cited by 31 publications

References 32 publications

Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats

Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats

Severe osteonecrosis of the jaw with attempted near total mandibular exfoliation

Infantile maxillary sinus osteomyelitis mimicking orbital cellulitis

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