Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines

Rothwell, Nancy J.

doi:10.1038/sj.bjp.0701248

Cited by 68 publications

(3 citation statements)

References 54 publications

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“…IL-1-RA is a specific endogenous receptor antagonist that blocks the actions of both IL-1α and IL-1β, but has no known agonist activity (Dinarello & Thompson, 1991). It appears that only IL-β is induced in the brain in response to injury or infection, or in sores (Rothwell, 1997a; b; Rothwell et al, 1997; Rothwell & Luheshi, 1994). IL-1 has several actions on the brain.…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims

Pandey

Rizavi

Ren

et al. 2012

Journal of Psychiatric Research

326

186

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Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and in the pathophysiology of depression—two major risk factors for suicide. Cytokines are increased in the serum of patients with depression and suicidal behavior; however, it is not clear if similar abnormality in cytokines occurs in brains of suicide victims. We therefore measured the gene and protein expression levels of proinflammatory cytokines interleukin (IL)-1β, IL-6, and tissue necrosis factor (TNF)-α in the prefrontal cortex (PFC) of 24 teenage suicide victims and 24 matched normal control subjects. Our results show that the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α were significantly increased in Brodmann area 10 (BA-10) of suicide victims compared with normal control subjects. These results suggest an important role for IL-1β, IL-6, and TNF-α in the pathophysiology of suicidal behavior and that proinflammatory cytokines may be an appropriate target for developing therapeutic agents.

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Section: Discussionmentioning

confidence: 99%

Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims

Pandey

Rizavi

Ren

et al. 2012

Journal of Psychiatric Research

326

186

View full text Add to dashboard Cite

show abstract

“…[6]) and thereby initiate inflammatory reactions in the central nervous system similar to those observed in neurodegenerative diseases, such as multiple sclerosis, Alzheimer and Parkinson diseases, etc. [7]. In our case, the differentiation process was irreversible and continued after the removal of the PP from the cell culture.…”

Section: Resultsmentioning

confidence: 76%

The Influence of a Probiotic Product on PC-12 Cell Differentiation

Sobol

Белостоцкая

2005

Dokl Biol Sci

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“…The immune system provides several defense mechanisms against infections, which on one hand contribute to elimination of the infectious agent but may also cause harmful effects by immune-mediated tissue damage [ 41 , 42 , 43 ]. For instance, pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α not only enhance protective adaptive immunity but also lead to host cell lysis and exuberant inflammation [ 44 , 45 , 46 ]. In the respiratory tract, epithelial cells form a physical barrier, which includes the mucociliary clearance mechanism and adherence through tight junctions preventing pathogen invasion [ 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and Transcriptional Changes of Pulmonary Immune Responses in Dogs Following Canine Distemper Virus Infection

Chludzinski¹,

Klemens²,

Ciurkiewicz³

et al. 2022

IJMS

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Canine distemper virus (CDV), a morbillivirus within the family Paramyxoviridae, is a highly contagious infectious agent causing a multisystemic, devastating disease in a broad range of host species, characterized by severe immunosuppression, encephalitis and pneumonia. The present study aimed at investigating pulmonary immune responses of CDV-infected dogs in situ using immunohistochemistry and whole transcriptome analyses by bulk RNA sequencing. Spatiotemporal analysis of phenotypic changes revealed pulmonary immune responses primarily driven by MHC-II+, Iba-1+ and CD204+ innate immune cells during acute and subacute infection phases, which paralleled pathologic lesion development and coincided with high viral loads in CDV-infected lungs. CD20+ B cell numbers initially declined, followed by lymphoid repopulation in the advanced disease phase. Transcriptome analysis demonstrated an increased expression of transcripts related to innate immunity, antiviral defense mechanisms, type I interferon responses and regulation of cell death in the lung of CDV-infected dogs. Molecular analyses also revealed disturbed cytokine responses with a pro-inflammatory M1 macrophage polarization and impaired mucociliary defense in CDV-infected lungs. The exploratory study provides detailed data on CDV-related pulmonary immune responses, expanding the list of immunologic parameters potentially leading to viral elimination and virus-induced pulmonary immunopathology in canine distemper.

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Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines

Cited by 68 publications

References 54 publications

Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims

Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims

The Influence of a Probiotic Product on PC-12 Cell Differentiation

Phenotypic and Transcriptional Changes of Pulmonary Immune Responses in Dogs Following Canine Distemper Virus Infection

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