Six Years' Experience in Treatment of Chromomycosis with 5‐Fluorocytosine

Cf, Lopes; Rj, Alvarenga; Eo, Cisalpino; Ma, Resende; Lg, Oliveira

doi:10.1111/ijd.1978.17.5.414

Cited by 46 publications

(8 citation statements)

References 4 publications

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“…Chemotherapy was used for long‐standing, very extensive cases with variable results. In most cases 5‐fluorocytosine and amphotericin B (intravenous) resulted in an important reduction of lesions and in cure in only one case for each drug; these results being similar to those reported in the literature [20–23]. Ketoconazole was later used at 200–600 mg day −1 doses, either as monotherapy or with calciferol (vitamin D2), with variable results.…”

Section: Discussionsupporting

confidence: 70%

Chromoblastomycosis: clinical and mycologic experience of 51 cases

Bonifáz

Carrasco‐Gerard

Saúl

2001

Mycoses

188

166

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This is a study of 51 cases of chromoblastomycosis detected in a 17-year period, all of which were clinically and mycologically proven by direct examinations, cultures and biopsies. The therapeutic results of the various treatments used are reported. Most cases were males (36 of 51; 70%), the mean age was 35 years and farmers predominated (74%); the most frequent lesions were in the lower limbs (54%). Major clinical presentations were nodular (41%) and verrucous (26%). The principal aetiologic agent isolated was Fonsecaea pedrosoi (90%). Overall results of the various treatments were as follows: 31% were cured, 57% improved and 12% failed. The best results were obtained with cryosurgery for small lesions, with itraconazole for large ones, and in some cases the combination of both treatments.

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Section: Discussionsupporting

confidence: 70%

Chromoblastomycosis: clinical and mycologic experience of 51 cases

Bonifáz

Carrasco‐Gerard

Saúl

2001

Mycoses

188

166

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“…Fluorocytosine (converted into 5-fluorouracil in fungal cells) shows some degree of efficacy but is associated with high risk of development of resistance, besides being hepatotoxic and myelotoxic. 123 With the emergence of more recent antifungals, the drug is now rarely used except in selected resistant cases.…”

Section: Treatmentmentioning

confidence: 99%

Chromoblastomycosis: an etiological, epidemiological, clinical, diagnostic, and treatment update

Brito

Bittencourt

2018

An. Bras. Dermatol.

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Chromoblastomycosis is a chronic, granulomatous, suppurative mycosis of the skin and subcutaneous tissue caused by traumatic inoculation of dematiaceous fungi of the family Herpotrichiellaceae. The species Fonsecaea pedrosoi and Cladophialophora carrionii are prevalent in regions where the disease is endemic. Chromoblastomycosis lesions are polymorphous: verrucous, nodular, tumoral, plaque-like, and atrophic. It is an occupational disease that predominates in tropical and subtropical regions, but there have been several reports of cases in temperate regions. The disease mainly affects current or former farm workers, mostly males, and often leaving disabling sequelae. This mycosis is still a therapeutic challenge due to frequent recurrence of lesions. Patients with extensive lesions require a combination of pharmacological and physical therapies. The article provides an update of epidemiological, clinical, diagnostic, and therapeutic features.

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“…26 With the emergence of newer antifungals it is rarely used nowadays except for resistant cases. Amphotericin B monotherapy is ineffective, and even in combination with other antifungals, results are generally poor, but a combination of amphotericin B and flucytosine has shown efficacy, with in vitro studies indicating synergistic activity between the two drugs.…”

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confidence: 99%