Six-year monitoring of the donor-specific immune response to cryopreserved aortic allograft valves: Implications with valve dysfunction

Use of an allograft patch in repair of hypoplastic left heart syndrome may complicate future transplantation

“…This finding, to the best of our knowledge, has not been previously reported in the literature for this population. Others have also reported a failure to develop an elevated PRA in response to allograft tissue; however, in these studies the HLA mismatch was not reported and thus the reason for the failure to develop antibodies is unclear [12,16]. Admittedly, there is potential for the results to be confounded by the increased use of blood products in recipients of allograft tissue.…”

“…Clinical studies by Baskett et al correlated enhanced cellular viability of aortic valve allografts with increased antigenicity and increased rate of valve failure [2]. Studies have also correlated HLA mismatch with increased rate of allograft valve failure [11,12]. Other studies in humans and animals have demonstrated an increase in donor-specific cytotoxic [13] and helper Tlymphocyte precursors [3].…”

Avaliação do comportamento biológico de homoenxertos valvares pulmonares descelularizados: estudo experimental em ovinos

“…immune response, both cellular, with activation of T lymphocytes, such as humoral, with the production of anti-HLA antibodies class I and II [10][11][12]14,15].…”

The Challenge of Homograft Tissue Banks: The Viability of Cryopreserved Valvular Homografts

“…Viable homografts have been demonstrated to elicit both a specific cellular and humoral immune response against HLA determinants of the donor. 4 It is a sub-clinical long-lasting response that leads to early and late valvular degeneration.…”