Six-year experience in continuous hypothermic pulsatile perfusion kidney preservation

Kwiatkowski, A.; Danielewicz, R.; Kosieradzki, Maciej; Polak, W.; Wszoła, Michał; Fesołowicz, S; Michalak, Grzegorz; Lisik, Wojciech; Malanowski, P.; Lao, M; Pączek, Leszek; Wałaszewski, J; Rowińskí, W

doi:10.1016/s0041-1345(00)02267-3

Cited by 15 publications

(11 citation statements)

References 6 publications

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“…Of these, nine [52][53][54][55][56][57][58][59][60] were published between 1974 and 1981, reporting seven studies of the use of perfusate flow characteristics and biochemical markers. A further 17 papers published since 1993 have been identified, [61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] reporting 11 studies. Details of all studies are given in Table 4.…”

Section: Papers Identified For Reviewmentioning

confidence: 99%

“…A further 17 papers have been identified, [61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] reporting 11 studies, all but one 77 of which were in NHBD or 'extended donor' kidneys. In only one of these 67,68 studies were kidneys not rejected from transplantation due to perfusion characteristics (thus making it impossible to assess how they would have performed if transplanted).…”

Section: Studies Published Since 1993mentioning

confidence: 99%

“…Clearly, without a proper control group, this conclusion is not justified. Four studies 63,[67][68][69]74,75,77 reported on the perfusion flow characteristics of kidneys which post-transplantation had immediate function (IF) or DGF. One of these 63 reported no differences in the perfusion characteristics, but the other three all reported higher flow, lower vascular resistance and lower lactate and LDH levels in kidneys with IF compared with DGF.…”

Section: Studies Published Since 1993mentioning

confidence: 99%

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The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Wight

Chilcott²,

Holmes³

et al. 2003

Health Technol Assess

124

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Section: Papers Identified For Reviewmentioning

confidence: 99%

Section: Studies Published Since 1993mentioning

confidence: 99%

Section: Studies Published Since 1993mentioning

confidence: 99%

See 1 more Smart Citation

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Wight

Chilcott²,

Holmes³

et al. 2003

Health Technol Assess

124

View full text Add to dashboard Cite

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“…Parameters such as pressure, resistance, time, and flow are continuously measured during HMP, and those have been linked to short‐term graft outcomes. Although, lower flow and higher renal resistance (RR) were associated with higher DGF , some publications suggest that RR during HMP demonstrated a poor predictive performance for the same outcome . Table summarizes the evidence, to date, on the relationship between pump parameters and KT outcomes.…”

Section: Introductionmentioning

confidence: 99%

Renal resistance thresholds during hypothermic machine perfusion and transplantation outcomes - a retrospective cohort study

et al. 2018

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Renal resistance (RR), of allografts undergoing hypothermic machine perfusion (HMP), is considered a measure of organ quality. We conducted a retrospective cohort study of adult deceased donor kidney transplant (KT) recipients whose grafts underwent HMP. Our aim was to evaluate whether RR is predictive of death-censored graft failure (DCGF). Of 274 KT eligible for analysis, 59% were from expanded criteria donor. RR was modeled as a categorical variable, using a previously identified terminal threshold of 0.4, and 0.2 mmHg/ml/min (median in our cohort). Hazard ratios (HR) of DCGF were 3.23 [95% confidence interval (CI): 1.12-9.34, P = 0.03] and 2.67 [95% CI: 1.14-6.31, P = 0.02] in univariable models, and 2.67 [95% CI: 0.91-7.86, P = 0.07] and 2.42 [95% CI: 1.02-5.72, P = 0.04] in multivariable models, when RR threshold was 0.4 and 0.2, respectively. Increasing risk of DCGF was observed when RR over the course of HMP was modeled using mixed linear regression models: HR of 1.31 [95% CI: 1.07-1.59, P < 0.01] and 1.25 [95% CI: 1.00-1.55, P = 0.05], in univariable and multivariable models, respectively. This suggests that RR during HMP is a predictor of long-term KT outcomes. Prospective studies are needed to assess the survival benefit of patients receiving KT with higher RR in comparison with staying wait-listed.

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“…The simplest method following kidney removal should be a strategy of primary cold static storage (CSS) for their transport to specialized centres to be reanimated and analyzed by oxygenated hypothermic pulsatile perfusion (HPP+ O 2 ) [1][2][3][4] . To date, the only way to reanimate and to test marginal organs is perfusion.…”

Section: Introductionmentioning

confidence: 99%

Oxygenated hypothermic pulsatile perfusion versus cold static storage for kidneys from non heart-beating donors tested by in-line ATP resynthesis to establish a strategy of preservation

et al. 2010

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Six-year experience in continuous hypothermic pulsatile perfusion kidney preservation

Cited by 15 publications

References 6 publications

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Renal resistance thresholds during hypothermic machine perfusion and transplantation outcomes - a retrospective cohort study

Oxygenated hypothermic pulsatile perfusion versus cold static storage for kidneys from non heart-beating donors tested by in-line ATP resynthesis to establish a strategy of preservation

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