Six Weeks to 45 Years: A Longitudinal Study of a Population with Down Syndrome

Carr, Janet

doi:10.1111/j.1468-3148.2011.00676.x

Cited by 26 publications

(28 citation statements)

References 35 publications

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“…The difference in findings between the results reported by Carr () and those reported by Couzens et al () may reflect a difference in receptive and expressive modalities. The subscales of the SB:IV require the respondent to answer verbally whereas the PPVT requires a pointing response only.…”

Section: Introductioncontrasting

confidence: 60%

Trajectories of Development of Receptive Vocabulary in Individuals with Down Syndrome

Cuskelly

Povey

Jobling

2016

Policy Practice Intel Disabi

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Receptive vocabulary is an important aspect of cognitive functioning. It appears to be a relative strength with respect to language for individuals with Down syndrome (DS) but little is known about its development as individuals mature. This study was designed to establish the developmental trajectory of receptive language development in individuals with DS from early childhood to midadulthood. Two hundred and six individuals with DS provided Peabody Picture Vocabulary Test (PPVT) scores on 957 occasions, spanning ages from 2 years 7 months to 29 years 7 months. Latent growth curve models were used to establish the trajectory of receptive vocabulary. Gender, maternal education, cohort, and nonverbal intellectual ability were used as predictors of rate of development. Receptive vocabulary was found to increase until around 20 years of age when performance on the PPVT began to deteriorate. The only variable measured that was associated with PPVT performance was nonverbal ability. The rate of increase in receptive vocabulary in individuals with DS across the childhood and adolescent period appears to be slower than for those who are developing typically, and the expected influence of maternal education was not found. The small number of participants contributing data in the older ages included in this study means that the apparent decline in receptive vocabulary scores needs to be interpreted cautiously.

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Section: Introductioncontrasting

confidence: 60%

Trajectories of Development of Receptive Vocabulary in Individuals with Down Syndrome

Cuskelly

Povey

Jobling

2016

Policy Practice Intel Disabi

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“…below the normal range threshold). Mean IQ scores for persons with TRS21, between 40 and 50 (Breia et al 2014 ;Carlier et al 2011 ;Carr 2012 ) is only an estimate, as scores are influenced by demographic characteristics of the study sample (e.g. age or the institutional environment) and the lowest score of the IQ test used (40 or 45 on the Wechsler scales, but lower for other tests).…”

Section: Introductionmentioning

confidence: 99%

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

et al. 2017

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“…DS is associated with intellectual abilities that range from only slightly below average for the general population to profound disability [4,5]. One key animal model for DS, the Ts65Dn mouse, has been extensively studied to better elucidate the neural mechanisms, including perturbations in neurotransmission thought to underlie the intellectual disabilities seen in individuals with DS [6].…”

Section: Intellectual Disability In Down Syndromementioning

confidence: 99%

Improving Memory and Cognition in Individuals with Down Syndrome

Rafii

2016

CNS Drugs

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Down syndrome (DS), often due to trisomy 21, is the most common genetic cause of intellectual disability (ID). In addition, virtually all individuals with DS develop the neuropathology of Alzheimer's disease (AD) by the age of 40 years and almost 60 % will manifest symptoms of AD dementia by the age of 65 years. Currently, there are no pharmacological treatments available for ID in individuals with DS and only limited symptomatic treatments for AD dementia. Advances in our understanding in both the molecular basis of ID and the pathogenesis of AD have created opportunities to study potential therapeutic targets. Recent studies in animal models of DS continue to provide a rational basis for translating specific compounds into human clinical trials. However, target and compound selection are only initial steps in the drug development pathway. Other necessary considerations include appropriate study designs to assess efficacy in the DS population, as well as operational aspects specifically tailored to assess cognition in this population. We discuss recent progress in the development of compounds for both ID and AD in individuals with DS, as well as concepts for the design and conduct of clinical trials with such compounds.

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Six Weeks to 45 Years: A Longitudinal Study of a Population with Down Syndrome

Abstract: While most of the cohort show few indications of decline in ability, a number now are or may be affected by AD, and this may require closer monitoring in the future.

Cited by 26 publications

References 35 publications

Trajectories of Development of Receptive Vocabulary in Individuals with Down Syndrome

Trajectories of Development of Receptive Vocabulary in Individuals with Down Syndrome

Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice

Improving Memory and Cognition in Individuals with Down Syndrome

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