Six weeks of Sofosbuvir/Ledipasvir treatment of acute hepatitis C Virus genotype 1 monoinfection: Final results of the German HepNet Acute HCV IV Study

End of treatment RNA-positive/sustained viral response in an individual with acute hepatitis C virus infection treated with direct-acting antivirals

“…Interestingly, Deterding and colleagues recently evaluated efficacy and safety of treatment with SOF + LED for 6 weeks in genotype-1 AHC patients. 5 In all patients, HCV RNA was undetectable by CTM before EOT and all patients achieved SVR. In conjunction with the case presented here, the report by Deterding and colleagues suggests that the EOT+/SVR pattern is more likely to be observed in AHC patients by the more sensitive ART assay than by CTM, as seen in CHC patients.…”

Treatment Options in Hepatitis C

“…patients acutely infected with HCV genotype 1 (8). It should be noted, however, that the combination of sofosbuvir and ledipasvir is available in Germany only in packages of 28 tablets, so that taking a single tablet per day for six weeks (i.e., 42 tablets total) is unreasonable in terms of drug economics.…”