Six synchronous primary neoplasms detected by FDG-PET/CT

Adriaensen, Miraude; Schijf, Laura; Haas, Marie de; Huijbregts, Julia; Baarslag, Henk-Jan; Staaks, Gerald; Klerk, John de

doi:10.1007/s00259-008-0821-2

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…These facts sometimes lead to changes in treatment modality with, for example, addition of concomitant chemotherapy or surgery and even to another treatment intention. In concordance with what others also have experienced, synchronous cancers are also detected when whole-body PET/CT is used for dose planning [3,4].…”

Section: Resultssupporting

confidence: 62%

PET/CT-Based Dose Planning in Radiation Therapy

Loft

Berthelsen

2014

Diseases of the Abdomen and Pelvis 2014–2017

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Section: Resultssupporting

confidence: 62%

PET/CT-Based Dose Planning in Radiation Therapy

Loft

Berthelsen

2014

Diseases of the Abdomen and Pelvis 2014–2017

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“…The use of FDG-PET/CT for tumor staging, detecting, and evaluating the prognosis has increased the detection rate of unexpected synchronous primary neoplasms [7]. Many studies showed that FDG PET/CT has good results in detecting a second primary tumor compared with radiologic methods and PET used alone [7][8][9][10][11][12]. For the same reason, we discovered the asymptomatic parotid masses incidentally in the conventional PET/CT application.…”

Section: Introductionmentioning

confidence: 84%

Efficacy of conventional whole-body 18F-FDG PET/CT in the incidental findings of parotid masses

et al. 2010

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“…Previously, multiple case reports and studies have been published presenting cases of unexpected synchronous primary lung tumours detected by FDG PET [23–26]. On the contrary, only few reports exist in which FDG PET contributes in determining the clonal origin of synchronous tumours [27, 28].…”

Section: Discussionmentioning

confidence: 99%

The role of 18F-FDG PET in the differentiation between lung metastases and synchronous second primary lung tumours

Dijkman

Schuurbiers

Vriens

et al. 2010

Eur J Nucl Med Mol Imaging

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PurposeIn lung cancer patients with multiple lesions, the differentiation between metastases and second primary tumours has significant therapeutic and prognostic implications. The aim of this retrospective study was to investigate the potential of 18F-FDG PET to discriminate metastatic disease from second primary lung tumours.MethodsOf 1,396 patients evaluated by the thoracic oncology group between January 2004 and April 2009 at the Radboud University Nijmegen Medical Centre, patients with a synchronous second primary lung cancer were selected. Patients with metastatic disease involving the lungs served as the control group. Maximum standardized uptake values (SUVs) measured with 18F-FDG PET were determined for two tumours in each patient. The relative difference between the SUVs of these tumours (∆SUV) was determined and compared between the second primary group and metastatic disease group. Receiver-operating characteristic (ROC) curve analysis was performed to determine the sensitivity and specificity of the ∆SUV for an optimal cut-off value.ResultsA total of 37 patients (21 metastatic disease, 16 second primary cancer) were included for analysis. The ∆SUV was significantly higher in patients with second primary cancer than in those with metastatic disease (58 vs 28%, respectively, p < 0.001). The area under the ROC curve was 0.81 and the odds ratio for the optimal cut-off was 18.4.ConclusionSUVs from 18F-FDG PET images can be helpful in differentiating metastatic disease from second primary tumours in patients with synchronous pulmonary lesions. Further studies are warranted to confirm the consistency of these results.

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Six synchronous primary neoplasms detected by FDG-PET/CT

Cited by 13 publications

References 4 publications

PET/CT-Based Dose Planning in Radiation Therapy

PET/CT-Based Dose Planning in Radiation Therapy

Efficacy of conventional whole-body 18F-FDG PET/CT in the incidental findings of parotid masses

The role of 18F-FDG PET in the differentiation between lung metastases and synchronous second primary lung tumours

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