Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial

Bo, Simona; Ponzo, Valentina; Ciccone, Giovannino; Evangelista, Andrea; Saba, Francesca; Goitre, Ilaria; Procopio, Massimo; Pagano, G; Cassader, Maurizio; Gambino, Roberto

doi:10.1016/j.phrs.2016.08.010

Cited by 123 publications

(99 citation statements)

References 44 publications

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“…Some studies2425 found resveratrol is able to improve glycemic control and insulin sensitivity. On the contrary, resveratrol did neither affect plasma glucose concentrations, nor decrease insulin resistance in other researches2627. As well as our peivious work, in current study, resveratrol treatment did not affect blood glucose in db/db mice, suggesting that the beneficial effect of resveratrol on DN is independent of the blood glucose levels.…”

Section: Discussioncontrasting

confidence: 46%

Resveratrol protects podocytes against apoptosis via stimulation of autophagy in a mouse model of diabetic nephropathy

Huang

Ding

Chen

et al. 2017

Sci Rep

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Podocyte apoptosis coincides with albuminuria onset and precedes podocytopenia in diabetic nephropathy. However, there is a lack of effective therapeutic drugs to protect podocytes from apoptosis. Here, we demonstrated that resveratrol relieved a series of indicators of diabetic nephropathy and attenuated apoptosis of podocytes in db/db diabetic model mice. In addition, resveratrol induced autophagy in both db/db mice and human podocytes. Furthermore, inhibition of autophagy by 3-methyladenine (3-MA) and autophagy gene 5 (Atg5) short hairpin RNA (shRNA) reversed the protective effects of resveratrol on podocytes. Finally, we found that resveratrol might regulate autophagy and apoptosis in db/db mice and podocytes through the suppression of microRNA-383-5p (miR-383-5p). Together, our results indicate that resveratrol effectively attenuates high glucose-induced apoptosis via the activation of autophagy in db/db mice and podocytes, which involves miR-383-5p. Thus, this study reveals a new possible strategy to treat diabetic nephropathy.

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Section: Discussioncontrasting

confidence: 46%

Resveratrol protects podocytes against apoptosis via stimulation of autophagy in a mouse model of diabetic nephropathy

Huang

Ding

Chen

et al. 2017

Sci Rep

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“…Following full text revision of remaining 289 articles, other 240 studies were excluded. Overall, 49 RCTs (Bahr et al, 2011; Bays et al, 2013; Bitzur et al, 2010; Bo et al, 2016; Breslavsky et al, 2013; Caballero et al, 2004; Chandler et al, 2014; Darghosian et al, 2015; Dawczynski et al, 2013; De Jager et al, 2005; de Jager et al, 2014; Duggan et al, 2015; Ebrahimi et al, 2009; Feher et al, 2014; Gagnon et al, 2014; Goldberg et al, 2014; Hass et al, 2014; Hutchins et al, 2013; Krysiak et al, 2011, 2013; Link et al, 2006; Magyar et al, 2012; Mazloom et al, 2013; Militaru et al, 2013; Mohamadshahi et al, 2014; Murphy et al, 2007; Nodari et al, 2011; Ogino et al, 2010; Paoli et al, 2015; Persson et al, 2006; Pooya et al, 2010; Pot et al, 2009; Pradhan et al, 2009; Rajkumar et al, 2014; Sadiya et al, 2015; Schiano et al, 2008; Shaseb et al, 2016; Sinha-Hikim et al, 2015; Sokol et al, 2012; Stricker et al, 2012; Tome-Carneiro et al, 2012; Tousoulis et al, 2008; Troseid et al, 2009; Valentini et al, 2015; van der Zijl et al, 2011; Witte et al, 2014; Xu et al, 2015; Zhao et al, 2009; Zittermann et al, 2009) were selected for the final analysis (one RCT (Rajkumar et al, 2014) was eligible among both omega −3 and probiotics). Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Five of 33 potential studies were identified upon resveratrol effect in a total of 372 participants (Bo et al, 2016; Magyar et al, 2012; Militaru et al, 2013; Tome-Carneiro et al, 2012; Witte et al, 2014). Table 6 presents main characteristics of the studies.…”

Section: Resultsmentioning

confidence: 99%

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis

Custodero

Mankowski

Lee

et al. 2018

Ageing Research Reviews

114

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Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism underlying the aging process. Some biological and pharmaceutical compounds may reduce systemic inflammation and potentially avert functional decline occurring with aging. The aim of the present meta-analysis was to examine the association of pre-selected interventions on two established biomarkers of inflammation, interleukin-6 (IL-6), and C-reactive protein (CRP) in middle-age and older adults with chronic LGI. We reviewed the literature on potential anti-inflammatory compounds, selecting them based on safety, tolerability, acceptability, innovation, affordability, and evidence from randomized controlled trials. Six compounds met all five inclusion criteria for our systematic review and meta-analysis: angiotensin II receptor blockers (ARBs), metformin, omega-3, probiotics, resveratrol and vitamin D. We searched in MEDLINE, PubMed and EMBASE database until January 2017. A total of 49 articles fulfilled the selection criteria. Effect size of each study and pooled effect size for each compound were measured by the standardized mean difference. I2 was computed to measure heterogeneity of effects across studies. The following compounds showed a significant small to large effect in reducing IL-6 levels: probiotics (−0.68 pg/ml), ARBs (−0.37 pg/ml) and omega-3 (−0.19 pg/ml). For CRP, a significant small to medium effect was observed with probiotics (−0.43 mg/L), ARBs (−0.2 mg/L), omega-3 (−0.17 mg/L) and metformin (−0.16 mg/L). Resveratrol and vitamin D were not associated with any significant reductions in either biomarker. These results suggest that nutritional and pharmaceutical compounds can significantly reduce established biomarkers of systemic inflammation in middle-age and older adults. The findings should be interpreted with caution, however, due to the evidence of heterogeneity across the studies.

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“…Although some studies have not found clear effects [64,65], many others have described the beneficial actions of resveratrol. In obese insulin-resistant adults after four weeks of resveratrol treatment, it has been observed that postprandial glucose decreased and glucose tolerance was not dose-dependent [66].…”

Section: Effects Of Nutrients On Gene Expression In the Pathogenesmentioning

confidence: 99%

“…Despite the many beneficial actions of curcumin and resveratrol, controversy rises when human clinical studies are considered [64,65]. Poor solubility and absorption of resveratrol when given orally and poor curcumin stability under certain cell culture conditions emphasize the need to optimise the experimental set-up.…”

Section: Effects Of Nutrients On Gene Expression In the Pathogenesmentioning

confidence: 99%

Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate

Ortega

Berná

Rojas

et al. 2017

IJMS

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Consistent evidence from both experimental and human studies indicates that Type 2 diabetes mellitus (T2DM) is a complex disease resulting from the interaction of genetic, epigenetic, environmental, and lifestyle factors. Nutrients and dietary patterns are important environmental factors to consider in the prevention, development and treatment of this disease. Nutritional genomics focuses on the interaction between bioactive food components and the genome and includes studies of nutrigenetics, nutrigenomics and epigenetic modifications caused by nutrients. There is evidence supporting the existence of nutrient-gene and T2DM interactions coming from animal studies and family-based intervention studies. Moreover, many case-control, cohort, cross-sectional cohort studies and clinical trials have identified relationships between individual genetic load, diet and T2DM. Some of these studies were on a large scale. In addition, studies with animal models and human observational studies, in different countries over periods of time, support a causative relationship between adverse nutritional conditions during in utero development, persistent epigenetic changes and T2DM. This review provides comprehensive information on the current state of nutrient-gene interactions and their role in T2DM pathogenesis, the relationship between individual genetic load and diet, and the importance of epigenetic factors in influencing gene expression and defining the individual risk of T2DM.

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Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial

Cited by 123 publications

References 44 publications

Resveratrol protects podocytes against apoptosis via stimulation of autophagy in a mouse model of diabetic nephropathy

Resveratrol protects podocytes against apoptosis via stimulation of autophagy in a mouse model of diabetic nephropathy

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis

Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate

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