Six-month outcome in acute kidney injury requiring renal replacement therapy in the ICU: a multicentre prospective study

Delannoy, Bertrand; Floccard, Bernard; Thiollière, Fabrice; Kaaki, Mahmoud; Badet, Michel; Rosselli, Sylvène; Ber, Charles; Saez, Alejandro A; Flandreau, Ghislain; Guérin, Claude

doi:10.1007/s00134-009-1588-z

Cited by 49 publications

(53 citation statements)

References 24 publications

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“…These patients were ∼7% worse concerning physical health, but 5% better concerning mental health compared with our data, thus confirming the general trend seen in our patients. Similar results were also seen by Delannoy et al 39 as early as 6 months after surviving AKI requiring RRT in the ICU. 39 Abelha et al 40 on the other hand indicated otherwise.…”

Section: Qolsupporting

confidence: 88%

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Health status, renal function, and quality of life after multiorgan failure and acute kidney injury requiring renal replacement therapy

Faulhaber-Walter

Scholz²,

Haller

et al. 2016

IJNRD

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Background: Critically ill patients with acute kidney injury (AKI) in need of renal replacement therapy (RRT) may have a protracted and often incomplete rehabilitation. Their long-term outcome has rarely been investigated. Study design: Survivors of the HANnover Dialysis OUTcome (HANDOUT) study were evaluated after 5 years for survival, health status, renal function, and quality of life (QoL). The HANDOUT study had examinded mortality and renal recovery of patients with AKI receiving either standard extendend or intensified dialysis after multi organ failure. Results: One hundred fifty-six former HANDOUT participants were analyzed. In-hospital mortality was 56.4%. Five-year survival after AKI/RRT was 40.1% (86.5% if discharged from hospital). Main causes of death were cardiovascular complications and sepsis. A total of 19 survivors presented to the outpatient department of our clinic and had good renal recovery (mean estimated glomerular filtration rate 72. Quality-adjusted life-years after 5 years were 3.365. Conclusion: Mortality after severe AKI is higher than short-term prospective studies show, and morbidity is significant. Kidney recovery as well as general health remains incomplete. Reduction of QoL is minor, and social rehabilitation is very good. Affectivity is heterogeneous, but most patients experience emotional well-being. In summary, AKI in critically ill patients leads to incomplete rehabilitation but acceptable QoL after 5 years.

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Section: Qolsupporting

confidence: 88%

“…Similar results were also seen by Delannoy et al 39 as early as 6 months after surviving AKI requiring RRT in the ICU. 39 Abelha et al 40 on the other hand indicated otherwise. These authors investigated QoL by SF-36 ™ in patients 6 months after AKI.…”

Section: Qolsupporting

confidence: 88%

Health status, renal function, and quality of life after multiorgan failure and acute kidney injury requiring renal replacement therapy

Faulhaber-Walter

Scholz²,

Haller

et al. 2016

IJNRD

View full text Add to dashboard Cite

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“…Two European studies used the Short Form Health Survey (SF-36) questionnaire to report QoL in ICU patients with AKI [8,9]. This assessment is also of global measures of health, covering eight health dimensions, of which mental health is just one, and the scores are aggregated.…”

Section: Discussionmentioning

confidence: 99%

“…Again, no assessment is made of the potential impact of events. One study [8] reported a reduction in QoL at six months, the other [9], which repeated the assessment at different time intervals, reported a reduction in three domains of the SF-36 for ICU patients with AKI compared with those without at ICU discharge, but this difference was no longer present at six months.…”

Section: Discussionmentioning

confidence: 99%

“…Among survivors, there is a continued adverse impact on quality of life (QoL) [4]. Studies that have assessed the impact of AKI with or without RRT on QoL have used global measures that incorporate physical, pain, social and other parameters, as well as psychological morbidity [2,[5][6][7][8][9][10][11][12]. There is a paucity of data on the specific psychological impact of RRT.…”

Section: Introductionmentioning

confidence: 99%

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Psychological outcomes in critically ill patients receiving renal replacement therapy: a matched‐pairs analysis

et al. 2014

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SummaryWe conducted a single-centre observational study over five years to assess the impact of renal replacement therapy on the psychological health of survivors of critical illness. We hypothesised that the added burden of renal replacement would increase the prevalence and severity of anxiety, depression and stress reactions in these patients, compared with matched pairs (matched for age, sex and APACHE II score) who did not receive renal replacement. Participants completed postal questionnaires. A total of 342 patients with acute kidney injury received renal replacement. One hundred and seventy-nine (52.3%) survived to hospital discharge, and 161 (47.1%) were alive at 90 days. Seventy-seven (47.8% of survivors) completed questionnaires. We found 77 matches for the Hospital Anxiety and Depression Scale analysis and 72 for the Impact of Events Scale analysis. Clinically relevant symptoms of psychiatric morbidity were common, with anxiety and depression affecting 49 (63.6%) patients and stress reactions affecting 24 (33.3%) patients. Mean scores (95% CI) were 11.4 (9.6-13.2) and 20.1 (15.7-24.6), respectively. On multivariate analysis, we found no significant differences between renal replacement patients and controls, in either the frequency or severity of these symptoms.

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Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients

et al. 2013

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Functional outcomes in long-term survivors of acute liver failure (ALF) are not well-characterized. The aim of this prospective study was to determine health related quality of life (HRQOL) in long-term adult ALF survivors. ALFSG registry participants completed the CDC HRQOL-14 and SF-36 questionnaires at a 1 and/or 2 year follow-up study visit. Responses were compared among ALF subgroups and to available U.S. general population controls. Among the 282 adult ALF patients, 125 had undergone liver transplantation (LT) while 157 were spontaneous survivors (SS), including 95 acetaminophen overdose (APAP) patients and 62 non-APAP SS. Acetaminophen SS patients reported significantly lower general health scores and more days of impaired mental and physical health, activity limitations due to poor health, pain, depression, and anxiety compared to the other groups (p < 0.001). There were no significant differences in coma grade, use of mechanical ventilation or ICP monitoring among the patient groups during their ALF hospitalization but the APAP SS had a significantly higher rate of psychiatric disease and substance abuse (p< 0.001). Compared to the U.S. general population, a greater proportion of the combined SS patients reported fair/poor health and >14 days of impaired physical/mental health and activity limitations due to poor health. In addition, a greater proportion of LT recipents reported >14 days of impaired physical/mental health. Similar results were observed using the SF-36 across the three ALF subgroups and compared to population controls. In conclusion, long-term adult ALF survivors report significantly lower quality of life scores compared to U.S. population controls. Furthermore, APAP SS patients report the lowest quality of life scores, possibly due to a higher rate of pre-morbid psychiatric and substance abuse disorders.

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Six-month outcome in acute kidney injury requiring renal replacement therapy in the ICU: a multicentre prospective study

Abstract: ICU survivors from RRT for AKI have an impaired QOL at 6 months, but sustained autonomy in their daily lives.

Cited by 49 publications

References 24 publications

Health status, renal function, and quality of life after multiorgan failure and acute kidney injury requiring renal replacement therapy

Health status, renal function, and quality of life after multiorgan failure and acute kidney injury requiring renal replacement therapy

Psychological outcomes in critically ill patients receiving renal replacement therapy: a matched‐pairs analysis

Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients

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