Six-Minute Walking-Induced Systemic Inflammation and Oxidative Stress in Muscle-Wasted COPD Patients.

Helvoort, Hanneke A. van; Heijdra, Y F; Swisher, Anne K.

doi:10.1097/01823246-200418020-00009

Cited by 6 publications

(8 citation statements)

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“…The production of TNF remained unchanged after mild exercise in healthy as well as diseased adults in three studies ( 220 , 222 , 224 ) and increased in another study ( 218 ) . The numbers of circulating total leucocytes, lymphocytes and monocytes increased after mild exercise ( 225 ) . Interestingly, in some studies, inflammatory cytokines increased after moderate exercise in patients, but not in control subjects.…”

Section: Challenge Modelsmentioning

confidence: 99%

A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

et al. 2013

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To monitor inflammation in a meaningful way, the markers used must be valid: they must reflect the inflammatory process under study and they must be predictive of future health status. In 2009, the Nutrition and Immunity Task Force of the International Life Sciences Institute, European Branch, organized an expert group to attempt to identify robust and predictive markers, or patterns or clusters of markers, which can be used to assess inflammation in human nutrition studies in the general population. Inflammation is a normal process and there are a number of cells and mediators involved. These markers are involved in, or are produced as a result of, the inflammatory process irrespective of its trigger and its location and are common to all inflammatory situations. Currently, there is no consensus as to which markers of inflammation best represent low-grade inflammation or differentiate between acute and chronic inflammation or between the various phases of inflammatory responses. There are a number of modifying factors that affect the concentration of an inflammatory marker at a given time, including age, diet and body fatness, among others. Measuring the concentration of inflammatory markers in the bloodstream under basal conditions is probably less informative compared with data related to the concentration change in response to a challenge. A number of inflammatory challenges have been described. However, many of these challenges are poorly standardised. Patterns and clusters may be important as robust biomarkers of inflammation. Therefore, it is likely that a combination of multiple inflammatory markers and integrated readouts based upon kinetic analysis following defined challenges will be the most informative biomarker of inflammation.

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Section: Challenge Modelsmentioning

confidence: 99%

A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

et al. 2013

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“…The Oxycon Mobile has been validated previously. 18,19 All measurements were performed by a trained investigator.…”

Section: Oxycon Mobilementioning

confidence: 99%

Dynamic Hyperinflation During Daily Activities

Hannink

Helvoort

Dekhuijzen

et al. 2010

Chest

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“…The duration of the endurance test was called the endurance limit time (TLim) (expressed in seconds). Two minutes after the end of the endurance test, a second maximal voluntary contraction test [MVC (2)] was performed to measure quadriceps fatigue. The sensation of muscle fatigue was also measured at rest and immediately after exercise on a 10 cm visual analogic scale.…”

Section: Study Protocolmentioning

confidence: 99%

“…In chronic obstructive pulmonary disease (COPD) patients, oxidative stress has been observed in muscle of these patients after exercice [1,2]. By inducing structural, metabolic and functional alterations in muscle, this oxidative stress is associated with the peripheral muscle dysfunction observed in these patients, as several studies from this group and others have reported [1,3,4].…”

Section: Introductionmentioning

confidence: 97%