Six Birds with One Stone: Versatile Nanoporphyrin for Single‐Laser‐Triggered Synergistic Phototheranostics and Robust Immune Activation

Abstract

Simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT) can reduce the risks of drug leakage, body burden, and preparation complexity in traditional combination PDT/PTT. Here, a versatile nanoporphyrin (Pp18‐lipos) self‐assembled from lipid–purpurin 18 conjugates (Pp18‐lipids) and pure lipids is presented. The as‐prepared Pp18‐lipos with 2 mol% Pp18‐lipids can perform effective PDT and fluorescence imaging. The Pp18‐lipos with 65 mol% Pp18 can perform potent PTT and photoacoustic imaging. The chelation of Mn2+ endows the Pp18‐lipids‐Mn2+ a high T1‐weighted magnetic resonance imaging contrast. Notably, pretreatment of low‐dose PDT facilitates the endocytosis and tumor accumulation of Pp18‐lipos, thus achieving synergistic PDT/PTT. Upon exposure to a single 705 nm‐laser, the combination of PDT/PTT achieves a significantly higher tumor growth inhibition rate than PDT or PTT alone. In addition, it is found that the synergistic PDT/PTT triggers more potent anti‐tumor immune response including tumor infiltration of immune cells and release of related cytokines.

Recent Development on Controlled Synthesis of Mn‐Based Nanostructures for Bioimaging and Cancer Therapy

“…[55][56][57] Additionally, hypoxia not only encouraged invasiveness of malignant cells but also led the resistance to treatments including radiotherapy (RT), [58,59] chemotherapy, and photodynamic therapy (PDT). [60][61][62][63][64][65] The efficacy of RT depended on radiosensitivity, which was directly related to the O 2 content of the tumor cells. O 2 could enhance and fix the radiation damage such as DNA double-strand break.…”

Water‐Soluble Organic Nanoparticles with Programable Intermolecular Charge Transfer for NIR‐II Photothermal Anti‐Bacterial Therapy

“…Organic materials with good near-infrared (NIR) responses are of interest for applications in photothermal therapy (PTT), which could effectively convert NIR light into thermal energy for cancer cells or bacteria ablation. [1][2][3][4][5] Currently, organic photothermal agents (PTAs) mainly include porphyrin, [6,7] indocyanine green, [8,9] organic radical, [10] and conjugated semiconductors [11][12][13] (such as polyaniline, [14] polypyrrole, [15] and polymer or monomer [16][17][18] ). which have merits of good biocompatibility and flexible design.…”

In vivo performance of electrospun tubular hyaluronic acid/collagen nanofibrous scaffolds for vascular reconstruction in the rabbit model

“…The ultimate goal of tissue-engineered vascular scaffolds is to promote vascular reconstruction and functional recovery of damaged vessels. The effect of reconstruction is closely related to the biophysical and biochemical signals from scaffolds [ 20 , 36 – 38 ]. In this study, collagen and HA were used as raw materials and a porous, hierarchical composite tubular vascular nanofibrous scaffold was successfully prepared by using the electrospinning technique.…”