SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Park, Yoon Kyung; Jangili, Paramesh; Zi, Soyu; Kang, Rae Hyung; Kim, Dokyoung; Kim, Jong Seung

doi:10.1039/d2cc03777g

Cited by 2 publications

(2 citation statements)

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“…Therefore, future work shall emphasize revealing innovative NIR-II molecules with an improved quantum yield at longer emission wavelengths to accomplish molecular imaging and directed surgery within the optimum spectral region . Molecular characterizations of the GBM microenvironment can advance the exploration of improved molecular imaging components . Therefore, multiple imaging agents comprising varied emission properties and different cellular targets would allow the real-time detection of the tumor cell and the difficult-to-imaging marginal tissue .…”

Section: Discussionmentioning

confidence: 99%

“…61 Molecular characterizations of the GBM microenvironment can advance the exploration of improved molecular imaging components. 137 Therefore, multiple imaging agents comprising varied emission properties and different cellular targets would allow the real-time detection of the tumor cell and the difficult-toimaging marginal tissue. 23 Further investigations on elucidating the clinical advantages of fluorescence-guided technology for glioma patients are also required.…”

Section: ■ Conclusionmentioning

confidence: 99%

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Recent Progress in Fluorescent Probes for Real-Time Monitoring of Glioblastoma

Mondal

Kang

Kim

2023

ACS Appl. Bio Mater.

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Treating glioblastoma (GBM) by resecting to a large extent can prolong a patient's survival by controlling the tumor cells, but excessive resection may produce postoperative complications by perturbing the brain structures. Therefore, various imaging procedures have been employed to successfully diagnose and resect with utmost caution and to protect vital structural or functional features. Fluorescence tagging is generally used as an intraoperative imaging technique in glioma cells in collaboration with other surgical tools such as MRI and navigation methods. However, the existing fluorescent probes may have several limitations, including poor selectivity, less photostability, false signals, and intraoperative readministration when used in clinical and preclinical studies for glioma surgery. The involvement of smart fluorogenic materials, specifically fluorescent dyes, and biomarker-amended cellpenetrable fluorescent probes have noteworthy advantages for precise glioma imaging. This review outlines the contemporary advancements of fluorescent probes for imaging glioma cells along with their challenges and visions, with the anticipation to develop next-generation smart glioblastoma detection modalities.

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Section: Discussionmentioning

confidence: 99%