Siwu Granules and Erythropoietin Synergistically Ameliorated Anemia in Adenine-Induced Chronic Renal Failure Rats

Wu, Yansheng; Wan, Qiang; Shi, Liqiang; Ou, Jiaoying; Li, Yingqiao; He, Fangping; Wang, Huiling; Gao, Jiandong

doi:10.1155/2019/5832105

Cited by 2 publications

(3 citation statements)

References 35 publications

(37 reference statements)

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“…lucida was evaluated on a model of CKD using adenine. The results showed that adenine administration was associated with a reduction in GSH, CAT, and SOD supporting the findings of many other authors [ 23 , 31 , 39 ]. This reduction in the antioxidant defense mechanism was more important in the kidney than in the heart; suggesting that in this model, oxidative stress first developed in the renal tissue and secondary in the cardiac tissue.…”

Section: Discussionsupporting

confidence: 90%

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The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats

Sonfack

Nguelefack‐Mbuyo

Kojom

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Chronic kidney disease (CKD) is a serious health problem with high morbidity and mortality, mainly attributable to cardiovascular risk. Garcinia lucida is traditionally used in Cameroon for the management of cardiovascular diseases. The aim of this study was to evaluate the cardioprotective and nephroprotective effects of the aqueous extract from the stem bark of G. lucida (AEGL). The in vitro antioxidant effect of AEGL was assessed at concentrations ranging 1–300 μg/mL against DPPH, lipid peroxidation, and AAPH-induced hemolysis. The reducing power and phenolic and flavonoids contents were also determined. CKD was induced by intraperitoneal bolus injection of adenine (50 mg/kg/day) for 4 consecutive weeks to male Wistar rats. AEGL (150 and 300 mg/kg/day) or captopril (20 mg/kg/day) was concomitantly administered with adenine per os. Bodyweight and blood pressure were monitored at baseline and weekly during the test. At the end of the experiment, plasma creatinine, urea, AST, and ALT were quantified. Proteinuria, creatinine excretion, and creatinine clearance were also assessed. The effect on GSH, CAT, and SOD activity was evaluated in cardiac and renal homogenates. Sections of the heart and kidney were stained with hematoxylin and eosin. AEGL exhibited a potent in vitro antioxidant activity and was shown to possess a large amount of phenolic compounds. Adenine alone increased blood pressure, cardiac and kidney mass, proteinuria, protein to creatinine ratio, plasma creatinine, AST, and urea levels ( p < 0.05 , 0.01, and 0.001). Besides, the bodyweight and creatinine clearance were significantly reduced ( p < 0.05 and p < 0.01 ). All these alterations were blunted by the plant extract, except the bodyweight loss. In addition, AEGL improved GSH levels and CAT and SOD activities. AEGL attenuated adenine-induced glomerular necrosis, tubular dilatation, and cardiac inflammation. AEGL exhibits cardioprotective and nephroprotective effects that may be ascribed to its antihypertensive and antioxidant activities.

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Section: Discussionsupporting

confidence: 90%

“…Many reports have evidenced the role of oxidative stress in the pathogenesis and progression of adenine-induced CKD [ 23 , 31 ]. Therefore, the antioxidant effect of G .…”

Section: Discussionmentioning

confidence: 99%

The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats

Sonfack

Nguelefack‐Mbuyo

Kojom

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…After the successful preparation of the myocardial infarction model, the AMI area was divided into four points and injected with 20 µl of physiological NaCl each (a total of 80 µl) at a distance of 1-2 cm. In the LIIL group and LIILR group, IL-6 recombinant protein (1.8 mg/kg) ( 26 , 27 ) or IL-6 receptor inhibitor (50 mg/kg) ( 28 ), respectively, were accordingly injected into the four points in the myocardial infarction area.…”

Section: Methodsmentioning

confidence: 99%

IL‑6 inhibitors effectively reverse post‑infarction cardiac injury and ischemic myocardial remodeling via the TGF‑β1/Smad3 signaling pathway

Wang

Xi³

et al. 2022

Exp Ther Med

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Approximately one in four myocardial infarctions occur in older patients. The majority of therapeutic advances are either not appropriate or not tested in elderly patients. The main reasons for deviating from the guidelines are justified concerns regarding the effectiveness of the recommended forms of therapy, fear of adverse drug reactions and ethical concerns. Targeting interleukin 6 (IL-6) for ventricular remodeling after cardiovascular damage is a feasible alternative to standard polypharmaceutics, but the underlying molecular mechanisms are not well understood. Continuous activation of the IL-6-associated cytokine receptor gp130 leads to cardiomyopathic hypertrophy. TGFβ1 is involved in forming fibrosis in various organs, and its overexpression can cause myocardial hypertrophy and fibrosis. Il-6 has been hypothesized to be indirectly involved in cardiac remodeling via the TGFβ1/Smad signaling transduction pathway. In the present study, a rat model of acute myocardial ischemia, IL-6 and IL-6 receptor blockers were injected directly into the necrotic myocardium. Changes in cardiac function, myocardial infarction area, myocardial collagen, necrotic myocardial fibrosis and levels of TGFβ1, IL-6 and MMP2/9 were quantified in myocardial tissue fibrosis by ELISA. The present study demonstrated that IL-6 stimulated myocardial fibrosis through the TGFβ1-Smad-MM2/9 signaling transduction pathway. Overall, this provided a solid foundation for understanding the relationship between IL-6 and ventricular remodeling.

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Siwu Granules and Erythropoietin Synergistically Ameliorated Anemia in Adenine-Induced Chronic Renal Failure Rats

Cited by 2 publications

References 35 publications

The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats

The Aqueous Extract from the Stem Bark of Garcinia lucida Vesque (Clusiaceae) Exhibits Cardioprotective and Nephroprotective Effects in Adenine-Induced Chronic Kidney Disease in Rats

IL‑6 inhibitors effectively reverse post‑infarction cardiac injury and ischemic myocardial remodeling via the TGF‑β1/Smad3 signaling pathway

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