SIV infection and ARV treatment reshape the transcriptional and epigenetic profile of naïve and memory T cells
in vivo
Andrew R. Rahmberg,
Tovah E. Markowitz,
Joseph C. Mudd
et al.
Abstract:Human and simian immunodeficiency viruses (HIV and SIV) are lentiviruses that reverse transcribe their RNA genome with subsequent integration into the genome of the target cell. How progressive infection and administration of antiretrovirals (ARVs) longitudinally influence the transcriptomic and epigenetic landscape of particular T cell subsets, and how these may influence the genetic location of integration are unclear. Here, we use RNAseq and ATACseq to study the transcriptomics and epigenetic landscape of l… Show more
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