To the Editor Dr Cifu 1 stated in his Viewpoint that diagnostic calibration is "…the relationship between diagnostic accuracy and physician confidence in that accuracy" and suggested static and dynamic influences determine diagnostic calibration. We agree with Cifu and Meyer et al 2 that the most worthwhile effort in improving diagnostic calibration is receiving regular feedback on diagnostic accuracy.However, we also advocate practicing metacognition and physicians educating themselves on the myriad cognitive biases that affect diagnostic decisions. These strategies promote the self-awareness that we believe is important for achieving appropriately calibrated confidence and diagnostic excellence.Static and dynamic influences determine diagnostic calibration and other factors such as fatigue, ambient conditions, and team dynamics contribute to diagnostic accuracy. Often, these static and dynamic factors lead physicians down an appropriate cognitive pathway or "cognitive disposition to respond" and to provide a correct diagnosis. 3 However, during periods of uncertainty, the summation of numerous static and dynamic factors may promote diagnostic misadventures.Awareness of these factors may be promoted during realtime clinical decision making. For example, by conducting "cognitive and affective autopsies" or a "diagnostic timeout" on rounds, trainees can increase their awareness of static and dynamic factors and review their actual cognitive response. Physicians in practice may find a similar approach helpful by routinely asking themselves the simple question, "What else could this be?" These brief reflections allow learners and practicing clinicians alike to refine their diagnoses in the context of associated dispositions and response. More importantly, they give physicians pause and an opportunity to recognize their level of diagnostic confidence.Cognitive errors or errors in data synthesis or faulty knowledge are purportedly the most common cause of diagnostic error. 4 Cognitive errors often occur as a result of overconfidence and overreliance on intuitive modes of thinking. 5 Using metacognition forces use of more analytical modes of thinking. Coupled with regular feedback on diagnostic performance, awareness of factors that influence decisions may realign clinicians' diagnostic confidence and accuracy. In effect, diagnostic calibration itself may be recalibrated toward diagnostic harmonization.