Situational Insomnia: Consistency, Predictors, and Outcomes

Bonnet, Michael H.; Arand, Donna L.

doi:10.1093/sleep/26.8.1029

Cited by 116 publications

(112 citation statements)

References 25 publications

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“…The present results are consistent with those of Bonnet and Arand 2003 [25], who found that subjects who had poor sleep on a laboratory adaptation night also showed consistent sleep disturbance following caffeine administration and a circadian phase-shift challenge. Our results compliment those findings using a mild stressor and show that such vulnerable individuals can be identified a priori.…”

Section: Discussionsupporting

confidence: 93%

“…The differentiation of a pharmacological from a psychological effect was not the question of the present study. However, other studies consistent with the current results suggest that the differential response is not likely due solely to a pharmacological effect [20,25]. Specifically, the current work and previous studies showing that certain 'vulnerable' individuals respond with sleep disturbance to the stress of a first-night effect, phase-shift challenges, and pharmacological challenges provide convincing evidence that this is likely a generalizable trait associated with vulnerability to multiple and distinct stressors.…”

Section: Discussionsupporting

confidence: 83%

“…This notion is supported by our previous work which showed that High FIRST individuals have greater acute sleep disturbance during a first night in the laboratory where cognitive awareness of the challenge was clearly apparent [20]. In another previous study, which did include a placebo condition, results were similar in that vulnerable individuals (albeit defined differently) were differentially more responsive to caffeine, suggesting that at least part of the vulnerability to sleep disturbance may include a purely physiological component [25]. The comparatively larger effects on sleep seen in that study are also consistent with this interpretation as the caffeine dose used was higher in the previous study (400 mg).…”

Section: Discussionsupporting

confidence: 62%

“…These findings suggest why multiple stressors across an array of categories such as medical or psychiatric disease and psychosocial stress may trigger chronic insomnia in some individuals but not others [31][32][33]. As the current data and other research [25] has suggested, there are specific individual differences responsible for the sleep-response to stress [7,20] and these differences may be markedly important in terms of the longitudinal development of insomnia [21].…”

Section: Discussionmentioning

confidence: 63%

“…In 2003, Bonnet and Arand [25], assessed the sleep-related response of individuals who demonstrated differentially poor sleep on laboratory adaptation and found that these individuals also had poor sleep in response to caffeine administration and a circadian phase-shift challenge. This demonstrationed the widely held belief that some individuals have a trait vulnerability to situational insomnia.…”

Section: Introductionmentioning

confidence: 99%

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Stress-related sleep disturbance and polysomnographic response to caffeine

et al. 2006

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Background and purpose-To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography.Patients and methods-Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64 ± 15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20 ± 13.73 years) on a measure of vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights.Results-There were no between-group differences in sleep on the control night. Importantly, individuals reporting vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P <0.05).Conclusion-Normal sleepers with an identified vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in vulnerability to sleep disturbance applies to a pharmacological 'stressor' (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Stress-related sleep disturbance and polysomnographic response to caffeine

et al. 2006

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Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder

et al. 2019

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This study aimed to investigate the relationship between sleep, psychopathology (anxiety, depression and presleep arousal) symptoms, and cortisol in adults with autism spectrum disorder (ASD). The sample composed of 29 adults with ASD (51.7% males) and 29 control adults (51.7% males) aged 21-44 years. Thirteen adults with ASD were medicated for a comorbid diagnosis of anxiety and/or depression (ASD-Med), while the remaining 16 adults with ASD were not medicated for such diagnoses (ASD-Only). Participants completed a questionnaire battery, 14-day sleep/wake diary and 14-day actigraphy assessment. On one day during the data collection period, participants collected five saliva samples, hourly, prior to sleep and two morning samples; immediately upon waking and 30 min thereafter for the analysis of cortisol. Cortisol 1 hr prior to habitual sleep onset time was associated with poorer sleep efficiency in both ASD groups and increased wake after sleep onset duration (ASD-Only). Higher subjective somatic arousal was also associated with increased sleep onset latency, regardless of group, and poorer sleep efficiency in the ASD-Only group. ASD-Only participants had significantly greater reductions in evening cortisol concentrations compared to both ASD-Med and control participants. No significant group differences were found for the cortisol awakening response. Findings suggest a hyperarousal hypothesis of insomnia in adults with ASD. Moreover, the low cortisol levels observed in ASD-Only adults suggest dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Longitudinal studies exploring the interplay between insomnia, anxiety and HPA axis regulation across the lifespan in those with ASD are warranted. Autism Res 2019, 12: 897-910.Lay Summary: Both objective (cortisol) and subjective (somatic) physiological arousal were associated with poor sleep quality in adults on the autism spectrum. Adults with autism spectrum disorder (ASD) who were not medicated for a comorbid diagnosis of anxiety and/or depression also had dampened cortisol secretion, suggesting a dysregulation of the hypothalamic pituitary axis. Longitudinal studies investigating the relationship between sleep, psychopathology symptoms and physiological arousal in autistic individuals are warranted.

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