Situation analysis of problems and prospects of the pediatric hematology-oncology in the CIS countries: the experience of a joint working group

Abstract

О р и г и н а л ь н ы е и с с л е д о в а н и я

Clinical and anamnestic features of the dynamics and transformation of iron-deficiency anemia in adolescent girls

“…The immunological syndrome, according to researchers, is a collective concept that includes a group of frequently ill (more than 4 times a year) children with respiratory and other viral infections, as well as exacerbation of chronic foci of infection. Numerous studies show that with ID, the resistance of children to infections decreases [1,3,5,12,13,14], which is due to a metabolism violation of iron-containing enzymes (cytochrome, cytochrome oxidase, peroxidase, catalase), especially leukocytes enzymes (myeloperoxidase, ketone proteins, flavoproteins)), a decrease in secretory Ig A, properdin, lysozyme, and many immunological defenses of the body [3]. Appendix 10 provides data on the study of the infection chronic foci frequency and exacerbation of viral infections in the examined girls with ID.…”

“…The origin of symptoms, such as sideropenic dysphagia, perversion of taste, smell, researchers associate with degenerative changes in the mucous membranes of the gastrointestinal tract (oral cavity, esophagus, stomach, intestines) and pharyngeal muscles due to iron deficiency [80; pp.54-57, 92; P. [4][5][6][7][8]. It has been shown that peripheral taste sensitivity is impaired in ID [1,5,7]. However, there is another opinion that hyposalivation, hypoenzymemia in the gastrointestinal tract develop in IDA in adults and children due to a violation of the motor-evacuation, secretory and enzymatic activity of the stomach, pancreas [3,4,9], since in IDA develops signs of chronic gastritis, gastroduodenitis with reduced secretion of gastric and other glands of the gastrointestinal tract.…”

“…The somatic health usefulness of puberty children is associated with the formation of reproductive functions, fertility, childbearing prognosis and the health level of future offspring, which determine the state potential and country development of the future. In recent decades, there has been no tendency to reduce the incidence of iron deficiency anemia (IDA), and the problem remains acute in health services in many regions of the world [1,2,3,4,5,6,7]. According to the World Health Organization, in any population, for every person suffering from IDA, there are three ones with iron deficiency (ID).…”

“…IDA clinical features in children of different ages have been studied and described in detail by many researchers [1,4,5]. However, as the analysis of modern literary sources shows [10,11,12,13,14,23], the IDA clinical course in children depends on many factors -age, gender, family history of anemia, region of residence, degree and stage of iron deficiency, and many others, which requires periodic updating of information on this issue.…”

“…As is known, IDA in adolescent girls for a long period was called juvenile chlorosis due to the pronounced pallor of the skin with a greenish tinge [1,2,3,4]. However, later it turned out that the IDA clinic in children, as in adults, is multifaceted and includes multiple syndromes or symptom complexes [16,17].…”