Situation analysis of colorectal cancer status in Uzbekistan and implementing measures to increase early detection and survival rate

Abstract

differences between right and left colon cancer. In India there are few studies on the comparison of left versus right colon cancer. As there is scant published literature we want to study the clinicopathological features and outcome differences in right versus left colon cancers. Methods: A total of 298 patients were studied. Among them 94 patients have stage IV disease. Remaining 204 patients have stage I,II,III disease.We evaluauted age,sex,site of the tumor,size of the lesion,nodal status,grade,lymphovascular invasion(LVI), perineural invasion(PNI),histology of the tumor,any presentation with obstruction or perforation,disease free survival(DFS) of stage I,II,III colon cancer pateints who had completed the surgery and who received at least 6 cycles of chemotherapy. Results: Out of 204 patients 109(54.43%) had right sided colon cancer and 95(46.57%) patients had left sided colon cancer.The median age of left and right colon cancer patients is 55(18-82),50(20-82) respectively.The male: female ratio is 2.18:1.Right sided colon cancer patients presented with statistically significant large tumor size(<0.0001),poorly differentiated histology(<0.0001),emergency presentation(Obstruction/Perforation).Though there is differnce in DFS between Right colon cancer and left colon cancer after multivariate analysis of DFS of all stage I,II,III patients it is not statistically significant.By stagewise subgroup analysis there is no significant survival diffrence between right and left colon cancer patients in stage II (P ¼ 0.5).But there is statistically significant difference in DFS between right and left colon cancer(p ¼ 0.02) in stage III patients. Univariate and multivariate analysis of Stage III colon cancer patients (92/204 patients) Conclusions: Stage III right sided colon cancer patients have statistically significant lower disease free survival when compared to stage III left sided colon cancer patients. Legal entity responsible for the study: Nizams Institute of Medical Sciences Funding: None Disclosure: All authors have declared no conflicts of interest. 173P Increasing disparities in age-related cause specific survival (CSS) among US patients with colorectal cancer: SEER analysis