Situação do pênfigo foliáceo endêmico em Mato Grosso do Sul, Brasil, 1990-1999

Chagas, Aucely Corrêa Fernandes; Ivo, Maria Lúcia; Honer, Michael Robin; Filho, Ruy Correa

doi:10.1590/s0104-11692005000200022

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…8 Frequency of 30.7 FS cases/ year through 1990 to 1999 in the State of Mato Grosso do Sul has been detected. 9 Endemic sites of PF were also found in other countries such as Colombia, Venezuela, Paraguay, and Peru. [10][11][12][13][14] Fogo Selvagem has a complex pathogenesis, which includes genetic, immunological, and environmental factors.…”

Section: Introductionmentioning

confidence: 91%

Profile of Trypanosoma cruzi Reactivity in a Population at High Risk for Endemic Pemphigus Foliaceus (Fogo Selvagem)

Sousa

Díaz²,

Eaton

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Fogo Selvagem (FS) is an autoimmune bullous disease with pathogenic IgG autoantibodies recognizing desmoglein 1 (Dsg1), a desmosomal glycoprotein. In certain settlements of Brazil, a high prevalence of FS (3%) is reported, suggesting environmental factors as triggers of the autoimmune response. Healthy individuals from endemic areas recognize nonpathogenic epitopes of Dsg1, and exposure to hematophagous insects is a risk factor for FS. Fogo selvagem and Chagas disease share some geographic sites, and anti-Dsg1 has been detected in Chagas patients. Indeterminate Chagas disease was identified in a Brazilian Amerindian population of high risk for FS. In counterpart, none of the FS patients living in the same geographic region showed reactivity against Trypanosoma cruzi. The profile of antiDsg1 antibodies showed positive results in 15 of 40 FS sera and in 33 of 150 sera from healthy individuals from endemic FS sites, and no cross-reactivity between Chagas disease and FS was observed.

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Section: Introductionmentioning

confidence: 91%

Profile of Trypanosoma cruzi Reactivity in a Population at High Risk for Endemic Pemphigus Foliaceus (Fogo Selvagem)

Sousa

Díaz²,

Eaton

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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“…14 In some endemic regions of Amerindians, in Mato Grosso do Sul State, Brazil, PF prevalence varies between 1.3% and 3%. 15,16 Thus, Brazil presents the highest incidence of PF worldwide (25-35 cases/million/year) 8,17 followed by Tunisia (6.7 cases/million/year). 14 Although pemphigus pathogenesis remains unclear, a combination of genetic and environmental factors has been indicated in relation to individual susceptibility to this disease.…”

Section: Introductionmentioning

confidence: 99%

Spatial Distribution of Pemphigus Occurrence over Five Decades in Southeastern Brazil

Celere

Vernal

Serra

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Well-defined locations of pemphigus cases support the hypothesis of environmental factors' involvement in its etiopathogenesis; however, these foci have never been described using specialized geographical tools. This is the first report to geo-reference pemphigus cases in a high-prevalence Brazilian region using geographic information systems. We aimed to report the spatio-temporal behavior of pemphigus foliaceus (PF) and vulgaris (PV) in southeastern Brazil, over the last five decades to describe geographical clusters, as well as to characterize the land use in the city with the highest number of cases. Patients were identified from 1965 to 2014. Maps were developed using ArcGIS software and organized into decades from 1965 to 2014. Ribeirão Preto was identified as the city with the greatest number of cases. Land use was analyzed within a 2 km-buffer surrounding the residence of each patient. A total of 426 cases of pemphigus were identified. PF was the predominant form (285 cases); notwithstanding, the number of new cases of PV rose, overtaking the number of new cases of PF in the last decade studied. Agricultural area (42%) and exposed soil (33.2%) are the most predominant land uses in Ribeirão Preto surrounding patients' residences. This study shows high-confidence geographical foci of PF and PV, as well as provides evidence of an increase of both clinical forms over the last five decades. All cases of PV and PF are in proximity to rivers and agricultural areas which reinforce the hypothesis that environmental factors play a role in pemphigus etiopathogenesis.

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