Sites of Production of Primate Serum Proteins Associated with the Complement System.

The Cells of Human Colostrum II. Synthesis of IgA and β1c

“…It has been shown previously that (Sic is produced by macrophages but not by lymphocytes [18,19]. Since the macrophages are the predominant cells in human colostrum, it is likely that they were responsible for the synthesis of /Sic in the cell cultures examined in this study.…”

C6 Produced by Macrophages Contributes to Cardiac Allograft Rejection

“…3,7 Selected complement components can be synthesized by mononuclear phagocytes, fibroblasts, endothelial cells, gastrointestinal and genitourinary epithelial cells, and adipocytes in vitro. 6,9,10 Since the first reports on the biosynthesis of complement by mononuclear phagocytes, 11 it has been documented that mononuclear phagocytes can synthesize all of the classical pathway components and most of the alternative pathway proteins. 12,13 However, evidence that complement synthesized by mononuclear phagocytes contributes to tissue injury is limited.…”

Modulation of delayed hypersensitivity in mice by cobra venom factor

“…Very recently a similar explanation was given for the effect of CoF on early IgM and IgG responses in mice, although not confirmed experimentally. A definitive conclusion concerning a possible direct involvement of C, in T-cell functions, however, will have to be deferred, as it was shown that macrophages are able to produce C, (30)(31)(32). The influence of in vivo CoF treatment on C3 production by macrophages will have to be elucidated first.…”