Sites of interleukin-6 release in patients with acute coronary syndromes and in patients with congestive heart failure

Deliargyris, Efthymios N.; Raymond, Ronald J.; Theoharides, Theoharis C.; Boucher, William; Tate, David A.; Dehmer, Gregory J.

doi:10.1016/s0002-9149(00)01121-8

Cited by 79 publications

(53 citation statements)

References 26 publications

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“…Furthermore, the source of inflammatory markers in ACS is still a matter of debate. It has also been shown that higher levels of IL-6 are found in the coronary artery when compared to the systemic arterial circulation in patients with ACS (13,14). While elevated inflammatory markers such as CRP and SAA, which are synthesised in the liver, indicate systemic inflammation, the above evidence supports the concept that intracoronary inflammation may also occur in close to proximity to the site of injury.…”

Section: Introductionmentioning

confidence: 64%

Microparticles in acute coronary syndrome

Mavroudis

Eleftheriou²,

Hong³

et al. 2017

Thrombosis Research

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Section: Introductionmentioning

confidence: 64%

Microparticles in acute coronary syndrome

Mavroudis

Eleftheriou²,

Hong³

et al. 2017

Thrombosis Research

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“…20) An elevated sino-arterial difference in the levels of IL-6 was reported in patients with acute coronary syndrome. 21) Thus, pro-inflammatory cytokines can be released by atherosclerotic coronary arteries. Although it is considered that increased local levels of pro-inflammatory cytokines may promote hepatic synthesis of CRP and SAA, CRP and SAA concentrations in peripheral blood have been found not to correlate with the angiographic severity of coronary artery disease in patients with stable angina.…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Soluble Thrombomodulin, C-reactive Protein, and Serum Amyloid A Protein in the Atherosclerotic Coronary Circulation

et al. 2003

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SUMMARYPlasma levels of C-reactive protein (CRP) and serum amyloid A protein (SAA), inflammatory markers, and soluble thrombomodulin (s-TM), a marker of endothelial damage, are thought to be related to coronary artery disease. However, the relationship between these inflammatory markers and endothelial injury in atherosclerotic coronary arteries is still unclear.Fifty-five patients who underwent coronary angiography were classified into 3 groups according to the severity of left coronary arterial atherosclerosis evaluated by the Gensini score (GS; normal: score = 0, n = 15; mild: 0 < score < 15, n = 29; severe: score ≥ 15, n = 11). Blood samples were obtained from the aortic root (Ao) and coronary sinus (CS) and plasma CRP and SAA levels were measured by latex turbidimetric immunoassays, and s-TM levels were determined by an enzyme-linked immunosorbent assay. The difference between marker concentrations in the Ao and CS of the coronary circulation was expressed as the coronary sino-arterial (CS-Ao) difference.The CS-Ao differences of s-TM and SAA were significantly higher in patients with severe atherosclerosis than in normal patients (P < 0.01), and showed weak but significant positive correlations with the GS (r = 0.34, P < 0.01 and r = 0.33, P < 0.05, respectively). The CS-Ao differences in CRP did not differ among the three groups, and did not correlate with the GS.The results of our study reveal a possible relationship between endothelial cell injury and inflammation in atherosclerotic coronary arteries. (Jpn Heart J 2003; 44: 601-612)

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“…The second hypothesis suggests that pro-inflammatory cytokines are activated in stressed myocardial tissue and that the elevated levels in the peripheral circulation represent a spillover from the cytokines produced locally in the myocardium [36][37][38]. The third hypothesis is that pro-inflammatory cytokines are produced by the peripheral tissues as a result of under perfusion [39]. The etiology for the increased levels of IL-6 in heart failure patients as compared to patients with coronary disease is not known.…”

Section: Discussionmentioning

confidence: 99%

The Immunoregulatory Role of Cytokines in Congestive Heart Failure

Chen¹,

Patel²,

Mohamed³

2014

Interdiscip J Microinflammation

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Background: Cytokines have been shown to be associated with heart failure and to have multiple biological effects that can lead to left ventricular dysfunction, pulmonaryedema, and left ventricular remodeling. However, the effects of different cytokines, separately and in combination have not been fully determined. We aim to evaluate the levels of both pro-inflammatory and anti-inflammatory cytokines in patients with congestive heart failure (CHF), as well as in patients with coronary artery disease (CAD) and compare them to levels in normal controls (individuals without CHF or CAD) as to suggest their possible etiologic role.

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Sites of interleukin-6 release in patients with acute coronary syndromes and in patients with congestive heart failure

Cited by 79 publications

References 26 publications

Microparticles in acute coronary syndrome

Microparticles in acute coronary syndrome

Plasma Levels of Soluble Thrombomodulin, C-reactive Protein, and Serum Amyloid A Protein in the Atherosclerotic Coronary Circulation

The Immunoregulatory Role of Cytokines in Congestive Heart Failure

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