Site‐Specific Patterning of Biomolecules and Quantum Dots on Functionalized Surfaces Generated by Plasma‐Enhanced Chemical Vapor Deposition

Slocik, Joseph M.; Beckel, Eric R.; Jiang, Hao; Enlow, Jesse; Zabinski, J.S.; Bunning, Timothy J.; Naik, Rajesh R.

doi:10.1002/adma.200600077

Cited by 34 publications

(42 citation statements)

References 39 publications

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“…In principle, it offers significant advantages: uniformly diverse functional coating deposition on various surfaces (even on complex 3D structures); precise control of thickness; and adaptability for large mass production processing. Surface amination by PECVD has previously been studied using, e.g., ethylene diamine (EDA) as precursor on different substrates (Gomathi 2008, Jung 2006, Slocik 2006. Unfortunately, the adhesion and stability of these PECVD deposited EDA films onto cycloolefin polymers were very poor (unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials

Volcke

Gandhiraman

Gubala

et al. 2010

Biosensors and Bioelectronics

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Functionalization of the plastic chips for selective immobilization of biomolecules is one of the key challenges to be addressed in commercialization of the next-generation point-of-care (POC) diagnostics devices. Multistep liquid-phase deposition process requires a large quantity of solvent to be used in anhydrous conditions, providing quantity of industrial liquid waste. We, in this work, have demonstrated a solventless plasma-based process that integrates low-cost, high throughput, high reproducibility and ecofriendly process for the functionalization of POC device platforms. Amine functionalities have been deposited by plasma-enhanced chemical vapour deposition 2 (PECVD) using a new precursor. For a successful and efficient plasma functionalization process, an understanding of the influence of plasma process parameters on the surface characteristics is essential. The influence of the plasma RF power and the deposition time on the deposited amount of amino functionalities and on their capacity to immobilize nano-objects (i.e., nanoparticles) and biomolecules (i.e. DNA) was examined. Surfacial properties were related to the binding capacity of the films and to the amino content, as revealed by the Ònanoparticle approachÓ and DNA attachment experiments. The key process determinants were to have a sufficient power in the plasma to activate and partially fragment the monomer but not too much as to lose the reactive amine functionality, and sufficient deposition time to develop a reactive layer but not to consume or erode the amine reactivity. An immunoassay performed using human immunoglobulin (IgG) as a model analyte shows an improvement of the detection limit by two orders of magnitude beyond that obtained using devices activated by liquid-phase reaction.

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Section: Introductionmentioning

confidence: 99%

Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials

Volcke

Gandhiraman

Gubala

et al. 2010

Biosensors and Bioelectronics

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“…TEM grids as physical masks have been used for patterning surfaces with SAMs, [9] polymers, [10,11] and SAM/polymer systems. [12] These grids have features on the micrometer scale, enabling the creation of micropatterns. Such a scheme was described recently by Malkov et Bifunctional surfaces are micropatterned using a self-aligned, dual-purpose lithographic mask and pairs of conformally deposited iCVD polymers.…”

Section: Introductionmentioning

confidence: 99%

Self‐Aligned Micropatterns of Bifunctional Polymer Surfaces with Independent Chemical and Topographical Contrast

Baxamusa¹,

Montero

Borrós

et al. 2010

Macromol. Rapid Commun.

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Bifunctional surfaces are micropatterned using a self-aligned, dual-purpose lithographic mask and pairs of conformally deposited iCVD polymers. A first layer is deposited, then physically masked and etched in oxygen plasma. A second layer is deposited with the mask still in place. Lift-off reveals the micropatterned surface. The thicknesses of the two layers are independently controlled so that the resultant surface displays both chemical and topographical contrast. The patterning scheme is independent of the polymers used and order of deposition. We use this scheme to create surfaces that spatially confine microcondensation, as well as chemical functionality. We also demonstrate microwells whose depth can be altered in response to a water stimulus.

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“…A selective BSA adsorption was found for the coated regions. Several other authors used the same plasma polymers, but different masking techniques or pattern sizes as proof of concept, excluding any in-vitro testing [77][78][79][80]. Source: Paik et al [76] Albeit being the most used precursor, allylamine is certainly not the only monomer available to deposit N-rich surfaces.…”

Section: Amine-rich Geometric Domainsmentioning

confidence: 99%

Non-thermal plasma assisted lithography for biomedical applications: an overview

Cools

Morent

2016

IJNT

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Plasma assisted surface patterning is becoming a well-established technique that introduces both alternating surface texture and chemistry on substrates for biomedical applications. This review consists of an overview on the developments in this field over the last 15 years. Special attention is given to the different kinds of chemistry that can be introduced and their effect on the surface-cell interaction, as well as their feasibility for possible applications in the field of regenerative medicine.

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Site‐Specific Patterning of Biomolecules and Quantum Dots on Functionalized Surfaces Generated by Plasma‐Enhanced Chemical Vapor Deposition

Cited by 34 publications

References 39 publications

Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials

Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials

Self‐Aligned Micropatterns of Bifunctional Polymer Surfaces with Independent Chemical and Topographical Contrast

Non-thermal plasma assisted lithography for biomedical applications: an overview

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