Site-Specific Opioid Receptor Blockade Allows Prepubertal Guinea Pigs to Display Progesterone-Facilitated Lordosis

Olster, Deborah H.

doi:10.1006/hbeh.1998.1442

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…One means by which mothers might suppress the sexual activity of their male offspring is with a pheromone. In female guinea pigs, evidence suggests that normal puberty involves removal of an overriding inhibitory influence exerted by the medial preoptic area and related structures on neuroendocrine mechanisms (Olster, 1998). Given the prominent role of the medial preoptic area in the sexual behavior of male rodents (Nyby, Matochik, & Barfield, 1992; Shimura, Yamamoto, & Shimokochi, 1994) and the indirect projections from the vomeronasal system through the medial amygdala to this region (Scalia & Winans, 1976; Simerly & Swanson, 1986), it is possible that the mothers emit a pheromone that acts through this circuit to inhibit the males from exhibiting sexual behavior toward them.…”

Section: Discussionmentioning

confidence: 99%

Rehousing periadolescent male guinea pigs (Cavia porcellus) apart from their mothers for 24 hours increases maternally directed sexual behavior and plasma testosterone.

Maken¹,

Hennessy²

1999

Journal of Comparative Psychology

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Periadolescent male guinea pigs (Cavia porcellus) housed continuously with their mother displayed little or no sexual behavior when they were tested with her in a novel environment. However, if males were rehoused without their mother for 24 hr before testing, they frequently directed courtship and sexual behavior toward her. This effect occurred whether the mother was isolated or not during the rehousing period. In addition, rehousing without the mother produced a significant rise in the plasma testosterone levels of the males. It appears that continuous housing with the mother inhibits sexual and courtship behavior directed toward her, as well as gonadal activity, in periadolescent male guinea pigs. These effects may serve to prevent inbreeding.

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Section: Discussionmentioning

confidence: 99%

Rehousing periadolescent male guinea pigs (Cavia porcellus) apart from their mothers for 24 hours increases maternally directed sexual behavior and plasma testosterone.

Maken¹,

Hennessy²

1999

Journal of Comparative Psychology

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“…For example, systemic or intracranial administration of µ-OR-selective ligands inhibits luteinizing hormone (LH) release and reproductive behavior in guinea pigs and rodents [8, 9, 10, 11]. Moreover, the general OR antagonist, naloxone, can stimulate LH release and reproductive behavior when given to hormone-primed females [8, 9, 11]. This has led to the hypothesis that endogenous opioids acting at µ-ORs normally exert a tonic inhibitory influence on both LH release and reproductive behavior.…”

Section: Introductionmentioning

confidence: 99%

Estrogen Modulation of Mu-Opioid Receptor-Stimulated [<sup>35</sup>S]-GTP-Gamma-S Binding in Female Rat Brain Visualized by in vitro Autoradiography

Acosta-Martínez

Etgen²

2002

Neuroendocrinology

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The µ-opioid receptor (OR) is involved in several aspects of female reproductive neuroendocrinology, such as the control of gonadotropin release and the display of lordosis behavior. Even though the neuroendocrine events modulated by µ-ORs are steroid hormone-dependent, few studies have shown how steroid hormones such as estrogen and/or progesterone can affect µ-OR function. Therefore, the present study investigated if in vivo estrogen or estrogen plus progesterone treatment of ovariectomized (OVX) rats affects µ-OR coupling to its G proteins. We used autoradiographic analysis of agonist-stimulated [³⁵S]-GTPγS binding, in which brain sections were incubated in the presence or absence of the µ-OR agonist [D-Ala², N-Me-Phe⁴, Gly²ol]-enkephalin (DAMGO). Film images were quantified using calibrated [¹⁴C] standards. Analysis was performed in steroid-responsive hypothalamic regions such as the medial preoptic area (mPOA) and the ventromedial nucleus of the hypothalamus, as well as in non-hypothalamic brain regions. Treatment with estrogen, alone or with progesterone, significantly increased DAMGO-stimulated [³⁵S]-GTPγS binding in the mPOA when compared to control OVX animals. In addition, estrogen increased µ-OR coupling in the caudate putamen. Steroid treatment had no effect on either basal or DAMGO-stimulated binding in the other brain regions examined. These findings suggest that estrogen modulates µ-OR function in a brain region-specific fashion. This could have important implications in terms of how these hormones synchronize reproductive behavior and gonadotropin release.

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Activation of μ-Opioid Receptors Inhibits Lordosis Behavior in Estrogen and Progesterone-Primed Female Rats

Acosta-Martínez

Etgen

2002

Hormones and Behavior

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Site-Specific Opioid Receptor Blockade Allows Prepubertal Guinea Pigs to Display Progesterone-Facilitated Lordosis

Cited by 8 publications

References 39 publications

Rehousing periadolescent male guinea pigs (Cavia porcellus) apart from their mothers for 24 hours increases maternally directed sexual behavior and plasma testosterone.

Rehousing periadolescent male guinea pigs (Cavia porcellus) apart from their mothers for 24 hours increases maternally directed sexual behavior and plasma testosterone.

Estrogen Modulation of Mu-Opioid Receptor-Stimulated [<sup>35</sup>S]-GTP-Gamma-S Binding in Female Rat Brain Visualized by in vitro Autoradiography

Activation of μ-Opioid Receptors Inhibits Lordosis Behavior in Estrogen and Progesterone-Primed Female Rats

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