Site-specific MOF-based immunotherapeutic nanoplatforms via synergistic tumor cells-targeted treatment and dendritic cells-targeted immunomodulation

Zhang, Huiyuan; Zhang, Jing; Li, Qian; Song, Aixin; Tian, Hailong; Wang, Jiqian; Li, Zhonghao; Luan, Yuxia

doi:10.1016/j.biomaterials.2020.119983

Cited by 96 publications

(91 citation statements)

References 57 publications

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“…[ 46 ] As a result, T cell‐mediated immune responses are initiated to eradicate cancer cells. [ 47 ] In an interesting example demonstrated by Luan and coworkers ( Figure a), [ 48 ] HA/IR820@ZIF‐8 with cancer cell‐specific targeting ability was prepared for PTT, and they reported the upregulation of TAAs and DAMPs. Meanwhile, imiquimod (R837), an immunoadjuvant, and immunomodulator 1‐methyl‐ d ‐tryptophan (1MT) were coloaded into ZIF‐8 coated with mannan (MAN/(R837 + 1MT)@ZIF‐8) for DC‐targeted immunotherapy.…”

Section: Synergistic Mechanism Of Htt In Immunotherapymentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

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Figure 3. a) Schematic illustration of the PTT-assisted immunotherapy. b) PD-L1 expression on 4T1 tumor cells after different treatments. c) Flow cytometric examination of the intratumor infiltration of CD4 + and CD8 + T cells. d,e) The primary and distal tumor growth curves of 4T1 tumor-bearing mice. f) Quantification of pulmonary metastasis nodules in different groups of 4T1 tumor-bearing mice. g) The tumor growth curves of B16F10-bearing mice model (*p < 0.05, **p < 0.01, ***p < 0.001). Reproduced with permission. [52] Copyright 2019, Nature Research.

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Section: Synergistic Mechanism Of Htt In Immunotherapymentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

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“…One is to deliver photothermal agent IR820 to tumor cells, and the other is to deliver the TLR7 agonist imiquimod R837 with the IDO inhibitor 1-methyl-d-tryptophan to DCs in tumor microenvironment. Thus, the two bioengineered ZIF-8 can realize fighting against invasive malignancy and rechallenged tumors via the spatiotemporally coordinated antitumor PTT and immunotherapy [141].…”

Section: Immunotherapy Combined With Photothermal Therapymentioning

confidence: 99%

Bioengineering of nano metal-organic frameworks for cancer immunotherapy

et al. 2020

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Immunotherapy techniques, such as immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell therapies and cancer vaccines, have been burgeoning with great success, particularly for specific cancer types. However, side effects with fatal risks, dysfunction in tumor microenvironment and low immune response rates remain the bottlenecks in immunotherapy. Nano metal-organic frameworks (nMOFs), with an accurate structure and a narrow size distribution, are emerging as a solution to these problems. In addition to their function of temporospatial delivery, a large library of their compositions, together with flexibility in chemical interaction and inherent immune efficacy, offers opportunities for various designs of nMOFs for immunotherapy. In this review, we overview state-of-the-art research on nMOFs-based immunotherapies as well as their combination with other therapies. We demonstrate that nMOFs are predominantly customized for vaccine delivery or tumor-microenvironment modulation. Finally, a prospect of nMOFs in cancer immunotherapy will be discussed.

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“…Metal-organic framework (MOF) nanoparticles (zeolitic imidazolate framework) are essentials to form strong interaction between drugs to increase the drug-loading efficacy. The nanoparticle based on metal-organic framework can comprehensively enhance the immunotherapy of various therapeutic agents [13,14]. 11.…”

Section: Common Nanoformulation Systems Loaded With Herbal Active Ingmentioning

confidence: 99%

A review on herbal drug loaded into pharmaceutical carrier techniques and its evaluation process

Sandhiya

Ubaidulla

2020

Futur J Pharm Sci

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Background: The herbal drug is molded in nanocarriers to boost growing interest in a pharmaceutical era for various fields in sort to amplify therapeutic worth. Nowadays, a promising interest has been developed in nanotechnology using herbal medicines as core material to provoke its activity on the target site. Main body: By administering herbal medicine in the nano-size form, there are chances for improving the bioavailability, binding receptor selectivity due to higher active surface energy thereby enhancing the effectiveness and safety of the active entity. In the last few decades, formulations with nano-sized herbal active ingredients have emerged as nano-phytomedicines owing to its wide range of interest and effectiveness because of its unique nature. Nanonized drug delivery structure of herbal drug has an approaching outlook for getting bigger the doings and overcome problems associated with plant medicine. The current review will focus on nanoparticles, herbal drug-loading techniques, herbal nanoformulations, and applications in various fields. Conclusion: We conclude that by formulating herbal drug in nanocarriers would be a promising guide for the progress of core remedy and will act as a promising proposal for many pathological conditions.

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Site-specific MOF-based immunotherapeutic nanoplatforms via synergistic tumor cells-targeted treatment and dendritic cells-targeted immunomodulation

Cited by 96 publications

References 57 publications

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Bioengineering of nano metal-organic frameworks for cancer immunotherapy

A review on herbal drug loaded into pharmaceutical carrier techniques and its evaluation process

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