Site‐Specific Control of Distances between Gold Nanoparticles Using Phosphorothioate Anchors on DNA and a Short Bifunctional Molecular Fastener

Lee, Jung Heon; Wernette, Daryl P.; Yigit, Mehmet V.; Liu, Juewen; Wang, Zidong; Lu, Yi

doi:10.1002/ange.200702569

Cited by 35 publications

(31 citation statements)

References 53 publications

(8 reference statements)

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“…Meanwhile, DNA-mediated assembly of nanoparticles provides an attractive way to organize both metallic and semiconducting nanoparticles into periodic or discrete one-, two-, and threedimensional architectures. [6][7][8][9][10][11][12][13] For example, double-stranded DNA (dsDNA) has served as a template for the deposition of conductive materials, including silver, copper, and carbon nanotubes. [9][10][11] Single-stranded DNA (ssDNA) has also been demonstrated as a template for silver metallization.…”

Section: Introductionmentioning

confidence: 99%

Site‐Specific DNA‐Programmed Growth of Fluorescent and Functional Silver Nanoclusters

Huang

et al. 2011

Chemistry A European J

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Precise organization of metallic nanoclusters on DNA scaffolds holds great interest for nanopatterned materials that may find uses in electronics, sensors, medicine, and many other fields. Herein, we report the site-specific growth of fluorescent silver nanoclusters by using a mismatched double-stranded DNA template. Few-atom, molecular-scale Ag clusters are found to localize at the mismatched site and the metallized DNA retains its integrity. The DNA-encapsulated nanoclusters can be utilized as functional biological probes to identify single-nucleotide polymorphisms by taking advantage of the very bright fluorescence and excellent photostability of the nanoclusters. This approach offers the possibility of constructing novel DNA-based nanomaterials and nanomechanical devices with more sophisticated functions and will be highly beneficial in future biochemical, pharmaceutical, nanomechanical, and electronic applications.

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Section: Introductionmentioning

confidence: 99%

Site‐Specific DNA‐Programmed Growth of Fluorescent and Functional Silver Nanoclusters

Huang

et al. 2011

Chemistry A European J

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“…The best known example is probably for anti-sense DNA to be more resistant to nucleases. 25 It is also used for assembling metallic nanoparticles, [26][27][28] proteins, 29 or semiconductor quantum dots, 30,31 and for biosensor development. 32,33 PS modification is valuable for studying enzyme mechanism as well.…”

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confidence: 99%

Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles

Zhou

Wang

Ding

et al. 2014

ACS Appl. Mater. Interfaces

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Unmodified DNA was recently used to functionalize gold nanoparticles via DNA base adsorption. Compared to thiolated DNA, however, the application of unmodified DNA is limited by the lack of sequence generality, adsorption polarity control and poor adsorption stability. We report that these problems can be solved using phosphorothioate (PS) DNA. PS DNA binds to gold mainly via the sulfur atom and is thus less sequence dependent. The adsorption affinity is ranked to be thiol > PS > adenine > thymine. Tandem PS improves adsorption strength, allows tunable DNA density, and the resulting conjugates are functional at a low cost.

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“…The key challenge is to develop general methodologies to assemble colloidal nano-objects with precise stoichiometry. Previously, homo-aggregates such as dimers and trimers were prepared by exploiting either random aggregation [6][7][8] , steric effects [9][10][11][12] or specific control over surface ligands (for example, divalent NPs) [13][14][15][16] . Compared with these 'homo-coupling' nanoreactions, controlling stoichiometry in the 'cross-coupling' of NPs presents different and arguably greater challenges.…”

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confidence: 99%

A systems approach towards the stoichiometry-controlled hetero-assembly of nanoparticles

et al. 2010

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A central theme in nanotechnology is to advance the fundamental understanding of nanoscale component assembly, thereby allowing rational structural design that may lead to materials with novel properties and functions. nanoparticles (nPs) are often regarded as 'artificial atoms', but their 'reactions' are not readily controllable. Here, we demonstrate a complete nanoreaction system whereby colloidal nPs are rationally assembled and purified. Two types of functionalized gold nPs (A and B) are bonded to give specific products AB, AB 2 , AB 3 and AB 4 . The stoichiometry control is realized by fine-tuning the charge repulsion among the B-nPs. The products are protected by a polymer, which allows their isolation in high purity. The integration of hetero-assembly, stoichiometry control, protection scheme and separation method may provide a scalable way to fabricate sophisticated nanostructures.

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Site‐Specific Control of Distances between Gold Nanoparticles Using Phosphorothioate Anchors on DNA and a Short Bifunctional Molecular Fastener

Cited by 35 publications

References 53 publications

Site‐Specific DNA‐Programmed Growth of Fluorescent and Functional Silver Nanoclusters

Site‐Specific DNA‐Programmed Growth of Fluorescent and Functional Silver Nanoclusters

Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles

A systems approach towards the stoichiometry-controlled hetero-assembly of nanoparticles

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