“…pp60 c-Src (c-Src) has been shown to associate directly with the platelet derived growth factor receptor (PDGFR) (Broome and Hunter, 1996) and CSF-1 receptor (Courtneidge et al, 1993). Src was also reported to interact with EGFR (Sato et al, 1995;Stover et al, 1995), and to phosphorylate the HER-2/ neu and IGF-1 receptors (Stover et al, 1995;Peterson et al, 1996). In these cases, c-Src phosphorylates unique phosphorylation sites on these receptors that serve as docking sites for downstream signal transducers like p85, the regulatory subunit of PI 3'-kinase and Shc (Stover et al, 1995).…”