Site‐Selective Suzuki–Miyaura and Sonogashira Cross Coupling Reactions of the Bis(triflate) of 2,4′‐Bis(hydroxy)diphenyl Sulfone

Abstract

Results and DiscussionBis(triflate) 2 was prepared in 81 % yield by reaction of commercially available 2,4'-bis(hydroxy)-diphenyl sulfone (1) with triflic anhydride (Scheme 1).Described is the synthesis of novel arylated and alkynylated 2,4'-diphenyl sulfones based on what are, to the best of our knowledge, the first palladium(0)-catalyzed cross-coupling re-actions of bis(triflates) of 2,4'-bis(hydroxy)diphenyl sulfone. The reactions proceed with very good site-selectivity.[a] Dr.

Palladium and Copper Catalyzed Sonogashira cross Coupling an Excellent Methodology for C-C Bond Formation over 17 Years: A Review

“…Khera and coworkers reported Pd catalyzed reactions and synthesis of bis(triflates) of 2,4 -bis(hydroxy) diphenyl sulfone [95]. In medicinal chemistry, arylated sulfones are important structural moieties because of their various biological activities such as anti-bacterial activity [96], antiHIV [97] and anti-cholesteremic [98] bis(hydroxy) diphenyl sulfone [95].…”

“…Khera and coworkers reported Pd catalyzed reactions and synthesis of bis(triflates) of 2,4 -bis(hydroxy) diphenyl sulfone [95]. In medicinal chemistry, arylated sulfones are important structural moieties because of their various biological activities such as anti-bacterial activity [96], antiHIV [97] and anti-cholesteremic [98] bis(hydroxy) diphenyl sulfone [95]. In medicinal chemistry, arylated sulfones are important structural moieties because of their various biological activities such as anti-bacterial activity [96], antiHIV [97] and anti-cholesteremic [98].…”