Site of action of gold thioglucose in the hypothalamic satiety center

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

“…The results of several electrophysiological [1,4,22,23] and pharmacological [7,9,21] studies appear to be compatible with these views. However, as will be argued in detail below, some loopholes remain to be filled before it can be definitively accepted that the VMH contains glucoreceptors in the above sense, which mediate glucostatic control of feeding behaviour in mammals under normal physiological conditions.…”

“…Another line of evidence is based on the hyperphagia seen after injury to the VMH caused by administration of goldthioglucose (GTG) [2,6,7,8,9,10,15,20,25,27]. It has been suggested that VMH glucoreceptors are unable to distinguish between GTG and glucose, take up GTG and then pay the penalty for their mistake [19].…”

The metabolic basis of dual periodicity of feeding in rats

“…As an alternative, Le Magnen suggests that the regulatory signal may be effected by "up" and "down-regulation" of insulin receptors in the VMH. This appears to place the insulin receptor as a causal rather than a permissive agent in the regulatory process, and thereby extends traditional thinking in the field (Debons, Krimsky, & From 1970). Past work suggested that the regulatory signal was at least partially based on energy input into the VMH rather than simply on the insulin sensitivity of the tissue.…”

Les mécanismes de régulation du bilan d'énergie

“…17) Magnen, 1983b (Havrankova et al, 1981 ;Van Houten et Posner, 1981). Depuis longtemps, des glucorécepteurs, distincts de ceux présents dans la région latérale, ont été localisés dans cette même région médio-ventrale, en particulier par la lésion par l'aurothioglucose chez la souris (Oomura, 1976 ;Debons et al, 1970aDebons et al, , b, 1974.…”