Sister Mary Joseph's nodule in malignant peritoneal mesothelioma

Boyde, Adam; Attanoos, Richard

doi:10.1046/j.1365-2559.2003.01669.x

Cited by 14 publications

(13 citation statements)

References 4 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 The metastases are typically ''dirty,'' with some neutrophils and nuclear dust of degenerate cells within the lumina of the gland. 109,110 Gastric Carcinoma 12) are positive in neoplastic cells, 106,107 whereas tumor cells lack reactivity for CK7.…”

Section: Cutaneous Metastases From Gastrointestinal Cancer Colorectalmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

View full text Add to dashboard Cite

Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

show abstract

Section: Cutaneous Metastases From Gastrointestinal Cancer Colorectalmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

View full text Add to dashboard Cite

show abstract

“…1,3 Local disease progression is typically the cause of death, although advanced mesothelioma may metastasize widely, including (rarely) to the skin (Table 1). [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Most cutaneous metastases are evident close to the primary tumor site, typically on the chest wall or abdomen, and sometimes in surgical scars or drain sites associated with the diagnosis or treatment of the mesothelioma. Exceptionally, malignant mesothelioma may present in the skin, before the primary tumor has become evident; this appears to be more common with peritoneal tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Exceptionally, malignant mesothelioma may present in the skin, before the primary tumor has become evident; this appears to be more common with peritoneal tumors. 6,8,12,13 Peritoneal malignant mesothelioma is a recognized cause of umbilical metastasis, giving rise to a Sister Mary Joseph nodule. 6,8,12 Spread to skin distant from the primary site is distinctly rare (Table 1).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant Mesothelioma Presenting as a Lip Tumor: Report of Two Cases With One Unrecognized by 166 Pathologists

Beer¹,

Heenan²

2007

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…4 It is an occasional sign of advanced intra-abdominal malignancy, and is normally associated with adenocarcinomas of the stomach, ovary and colon. It has also been described with adenocarcinomas of the pancreas, endometrium and breast as well as malignant peritoneal mesothelioma, 5 but there are no previous reports involving primary gastric lymphoma.…”

mentioning

confidence: 99%