Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma

Ioannidis, Orestis; Cheva, Angeliki; Stavrakis, Thomas; Paraskevas, George P.; Papadimitriou, Nikolaos; Kakoutis, Emmanouil; Makrantonakis, Apostolos

doi:10.1016/j.gcb.2010.07.005

Cited by 9 publications

(9 citation statements)

References 9 publications

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“…[ 7 ] Although the patient had a 20-day history of abdominal distension, she did not tell the clinician her situation when she visited the doctor for 75-g OGTT 2 weeks ago. There are some rare symptoms, such as low back pain and bilateral erythematous breast hypertrophy, mimicking primary inflammatory breast carcinoma reported by Mandato et al, [ 10 ] Sister Mary Joseph's nodule reported by Ioannidis, and pericardial tamponade reported by Bacic et al [ 11 , 12 ]…”

Section: Case Reportmentioning

confidence: 99%

Advanced gastrointestinal carcinoma with massive ascites and hydrothorax during pregnancy

Ye¹,

Tang

Yao

et al. 2017

Medicine

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Rationale:Gastrointestinal carcinoma is rare during pregnancy. It is usually diagnosed at an advanced stage because special gastrointestinal symptoms are generally overlooked during pregnancy, and there are many limitations and contraindications for using diagnostic tools during pregnancy.Patient concerns:We present a case of a 29-year-old patient with 27 weeks and 5 days of gestation due to massive ascites and hydrothorax.Diagnoses:The patient was diagnosed with an advanced gastrointestinal cancer. Pathological report showed poorly differentiated tumor with the signet ring cell component.Interventions:Caesarean section was performed. At the same time, an abdominal exploration showed that the omentum was like biscuits . There were extensive and firm intestinal adhesions, and many tumor lesions were found on the surface of greater curvature of stomach, spleen, intestine, peritoneum, ascending colon and descending colon.Outcomes:Gastrointestinal surgeon was invited during operation, and palliative gastrectomy was not performed because of extensive metastases. The patient died 30 days after caesarean section.Lessons:This study present a case with advanced gastrointestinal cancer during pregnancy. We suggest that endoscopic exam is recommended if the patient is highly suspicious.

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Section: Case Reportmentioning

confidence: 99%

Advanced gastrointestinal carcinoma with massive ascites and hydrothorax during pregnancy

Ye¹,

Tang

Yao

et al. 2017

Medicine

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“…Metastasis to the umbilicus from GC is a rare condition, and only few cases have been previously reported [7][8][9][10][11][12][13][14][15]. SMJN is the term commonly used to refer to cutaneous metastasis from internal malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis to the umbilicus may be the only presenting symptom. However, solitary umbilical metastases are extremely rare, and most patients present in a poor clinical state with several physical signs such as ascites and pleural effusion [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

A Huge Sister Mary Joseph’s Nodule From Signet Ring Cell Gastric Carcinoma Showing Good Response to FOLFOX-Based Chemotherapy Regimen

et al. 2022

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Metastatic involvement of the umbilicus as a result of a visceral carcinoma is a rare entity known as Sister Mary Joseph's nodule (SMJN). The most common primary sites are the gastrointestinal and gynecological tract. The occurrence of SMJN is commonly associated with advanced peritoneal disease and poor prognosis. The average survival time at the appearance of an umbilical metastasis is estimated at 10 months, and only 13% of patient will be alive at 2 years. Treatment usually involves systemic chemotherapy and palliative care, but the possibility of surgical resection should be considered especially if good response to systemic treatment is achieved in selected patients to maintain or to improve the quality of life. We describe here an unusual case of a 60-year-old man referred with enlarging umbilical lesion, identified as SMJN, that was metastasized from advanced signet ring cell carcinoma of the stomach with generalized peritoneal carcinomatosis. The nodule had rapid progression, and in a few days had reached 15 cm. Chemotherapy was started immediately and patient achieved good clinical and radiological response. A resection of the umbilical nodule was discussed but the patient unfortunately died following a massive pulmonary embolism. This case is unique in view of the unusual size of the SMJN in our patient and the good response to chemotherapy. We present this case to increase physician's awareness for careful evaluation of the umbilical area and encourage them to look for a primary digestive tumor if an umbilical nodule is observed. Therapeutic response to primary chemotherapy may encourage a multimodal approach allowing resectability of the metastatic umbilical nodule.

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“…7 Furthermore, the spread of malignant cells could have occurred via embolization through the arterial blood supply to the umbilicus. 7,10 …”

Section: Discussionmentioning

confidence: 99%

Sister Mary Joseph’s Nodule: A Rare Cytologic Presentation

Akhtar¹,

Zaheer²,

Shadi³

et al. 2011

Clinics and Practice

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Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. It indicates neoplasm of inner organs mostly located in the gastrointestinal tract or the pelvis. However, in approximately 15–30% the primary tumor remains occult. In most cases, Sister Mary Joseph's nodule appears as an early and sometimes the only symptom of the malignancy. Here we report a rare fine needle aspiration (FNA) cytologic diagnosis of umbilical metastasis of an ovarian carcinoma.

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Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma

Cited by 9 publications

References 9 publications

Advanced gastrointestinal carcinoma with massive ascites and hydrothorax during pregnancy

Advanced gastrointestinal carcinoma with massive ascites and hydrothorax during pregnancy

A Huge Sister Mary Joseph’s Nodule From Signet Ring Cell Gastric Carcinoma Showing Good Response to FOLFOX-Based Chemotherapy Regimen

Sister Mary Joseph’s Nodule: A Rare Cytologic Presentation

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