Sister chromatid exchange rate from pleural fluid cells in patients with malignant mesothelioma

Atalay, Figen; Baltacı, Volkan; Alpas, İdil; Savaş, İsmail; Atikcan, Şükran; Balcí, Sevim

doi:10.1016/s1383-5718(99)00224-7

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…The SCE is one of the most important tests to demonstrate the correlation with cancer and the DNA damage 21 . However, we think that it might be more appropriate if this work is supported by the other detection methods.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on DNA damage in non breast‐fed infants

Dündaröz¹,

Aydin²,

Ulucan³

et al. 2002

Pediatrics International

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Section: Discussionmentioning

confidence: 99%

Preliminary study on DNA damage in non breast‐fed infants

Dündaröz¹,

Aydin²,

Ulucan³

et al. 2002

Pediatrics International

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“…But in respect to asbestos-exposed inhabitants, it has been shown that the rates of SCE were higher in exposed inhabitants compared to controls from Turkey (Dö nmez et al 1996;Atalay et al 2000). However, the asbestos-induced MN frequency in cultured V79 cell lines (Lu et al 1994), in cultured SHE fibroblasts (Dopp et al 1995(Dopp et al , 1997Dopp & Schiffmann 1998) and in cultured HBE cells (Kodama et al 1993) has been shown in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Still some other studies showed enhanced SCE in cultured human lymphocytes of asbestos-exposed workers (Rom et al 1983;Fatma et al 1991;Lee et al 1999) and inhabitants (Dö nmez et al 1996). Atalay et al (2000) found that the SCE frequencies in the pleural effusion cells of patients with malignant mesothelioma were significantly higher than in the controls.…”

mentioning

confidence: 84%

Investigation of micronucleus frequencies in lymphocytes of inhabitants environmentally exposed to chrysotile asbestos

Dönmez-Altuntaş¹,

Baran²,

Oymak

et al. 2007

International Journal of Environmental Health Research

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Exposure to asbestos minerals has been associated with a wide variety of adverse health effects including lung cancer, pleural mesothelioma, and cancer of other organs. Many of the regions of Turkey have asbestos deposits. People in Doğanli village - one of these regions - have been environmentally exposed to chrysotile asbestos since they were born. In this study the effects of asbestos on micronucleus (MN) frequencies of inhabitants exposed to chrysotile asbestos have been examined. Thirty subjects who had been environmentally exposed to chrysotile asbestos and living in Doğanli village, and 25 controls were studied to assess the MN frequency. The control group was selected from healthy individuals with no exposure to asbestos and living in similar geographic conditions to Doğanli village. Peripheral blood samples were collected from each subject and cultured for MN assay. Cytochalasin-B was added to lymphocyte cultures for evaluation of MN in binucleated (BN) cells. The differences between those exposed to chrysotile asbestos and controls were not statistically significant in terms of BN cells with MN (p > 0.05). There was not a significant relationship between MN frequencies and age, sex, smoking, both in chrysotile asbestos-exposed subjects and in controls (p > 0.05). Although the detection of calcified pleural plaques found in the inhabitants has indicated environmental exposure to chrysotile asbestos, our results show that chrysotile asbestos was not an inducer of MN in subjects exposed to chrysotile asbestos.

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“…The frequency of sister chromatid exchange (SCE), the occurrence of micronuclei (MN), and the proliferation rate index (PRI) have been used extensively for cytogenetic examination of peripheral lymphocytes in determining the mutagenic effects of chemotherapeutic drugs (Raposa and Várkonyi, 1987;Digkas et al, 2010). These measures are indicators of exposure to genotoxic chemicals and markers of genome instability and disease states (Carbonell et al, 1996;Kang et al, 1997;Dhillon and Dhillon, 1998;Atalay et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic findings in patients diagnosed with breast cancer having undergone adjuvant chemotherapy regimens

Kosar

Koçer

et al. 2016

Genet. Mol. Res.

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The aim of the present study was to investigate DNA damage in peripheral blood lymphocytes of breast cancer (BC) patients before and after administration of chemotherapy. We analyzed the frequency of sister chromatid exchange (SCE), occurrence of micronuclei (MN), and lymphocyte proliferation rate index (PRI) as cytogenetic markers in 28 female BC patients before and after chemotherapy, and in 20 age-matched healthy female volunteers. Prior to treatment, BC patients showed significantly increased background levels of SCE and MN, and lowered PRIs compared to healthy women. In comparison with pre-treatment levels, SCE and MN frequencies were significantly elevated and PRI reduced in blood samples collected after chemotherapy. Our findings indicate that SCE, MN, and PRI may serve as sensitive biomarkers for routine detection of the genetic abnormalities that may occur following administration of antineoplastic drugs in the clinical setting, as well as for the monitoring of high-risk patients receiving chemotherapy for BC.

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Sister chromatid exchange rate from pleural fluid cells in patients with malignant mesothelioma

Cited by 9 publications

References 9 publications

Preliminary study on DNA damage in non breast‐fed infants

Preliminary study on DNA damage in non breast‐fed infants

Investigation of micronucleus frequencies in lymphocytes of inhabitants environmentally exposed to chrysotile asbestos

Cytogenetic findings in patients diagnosed with breast cancer having undergone adjuvant chemotherapy regimens

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