Sistemik Lupus Eritematozus Hastalarında İnflamasyon Belirteci ve Yüksek Hastalık Aktivite Göstergesi Olarak Yeni Hematolojik İndeksler

Ermurat, Selime; Tezcan, Dilek

doi:10.32708/uutfd.1110778

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…[16–18] Also PIV and SII investigated for investigated the predictability of malignancy prognosis. [24–26]…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18] Also PIV and SII investigated for investigated the predictability of malignancy prognosis. [24][25][26] Satış [27] evaluated a relationship with SII and disease activity levels in patients with RA, but CRP and other inflammatory parameters were not considered in the study. Likewise our study; SII levels were higher in active RA patients have higher SII levels than patients with remission RA.…”

Section: Tablementioning

confidence: 99%

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The relationship between disease activity with pan-immune-inflammatory value and systemic immune-inflammation index in rheumatoid arthritis

Başaran,

Dogan

2024

Medicine

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Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease. Immune system cells have an important role in RA. Our aim was to investigate the relationship between disease activity, systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV) levels in RA patients. We planned to investigate whether these 2 measurements have an advantage over each other. About 67 patients diagnosed with RA and 49 healthy controls included in this study. RA was diagnosed based on 2010 ACR classification criteria. In this cross-sectional study, peripheral blood tests, C-reactive protein (CRP), hemogram, and erythrocyte sedimentation rate levels were noted after the physical examination of all participants. PIV was calculated with the formula: (neutrophil count × platelet count × monocyte count) / lymphocyte count. SII was calculated as follows: (neutrophil count × monocytes count) / lymphocyte count. The disease activity score 28 (DAS28) were noted in patients with RA. CRP values of active RA group were significantly higher than remission RA and control groups (P < .001), control and remission RA groups were similar (P = .86). PIV and SII are significantly higher in active RA than remission RA and control (P < .001, P < .001) higher in remission RA than control (P < .001, P < .001). Receiver operating characteristic curve analysis in predicting remission compared to the control group, CRP was not significant, PIV and SII was significant and PIV has higher sensitivity and sensitivity, a PIV value of > 217.31 have sensitivity 75.0% and specificity 85.7%. CRP, PIV, and SII are statistically significant in predicting active RA compared to the remission RA and control group. Our findings show that PIV, and SII are easy, inexpensive and reliable markers predicting remission in RA patients. CRP was not significant compared to remission RA and control group, PIV and SII was significant and PIV has higher sensitivity and specificity than SII in the remission group in RA. Patients with high disease activity, PIV, SII, and CRP levels were effective in showing disease activity compared to RA remission group and healthy controls.

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“…[16–18] Also PIV and SII investigated for investigated the predictability of malignancy prognosis. [24–26]…”

Section: Discussionmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

The relationship between disease activity with pan-immune-inflammatory value and systemic immune-inflammation index in rheumatoid arthritis

Başaran,

Dogan

2024

Medicine

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“…22 In a study performed on systemic lupus erythematosus (SLE) patients, SII and SIRI values were found to be higher in patients with SLE compared to the control group when compared to healthy controls. 23 As far as we know, a study on varicocele patients based on SII and SIRI values is not available. Similar to the other diseases mentioned above, we found that patients who benefited from varicocelectomy had significantly lower SII and SIRI values.…”

Section: Discussionmentioning

confidence: 99%

The effect of systemic inflammatory index and systemic inflammatory response index on success of varicoselectomy

Erdogan,

2023

Urologia

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Background: Varicocele is the most common correctable cause of male infertility. The treatment of varicocele is surgery. However, which patients will benefit from the surgery is controversial. Our aims to investigate the effect of systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) on varicocelectomy success. Methods: Patients who underwent varicocelectomy in our clinic between January 2016 and June 2022 were analyzed retrospectively. Varicocelectomy success was defined as >50% increase in post-operative total motile sperm count (TMSC) in those with pre- operative TMSC > 5 million and at least 100% increase in those with <5 million. The patients were divided into two groups as benefiting from the treatment (Group 1) and no benefits (Group 2). Results: Of the 207 patients who underwent varicocelectomy, 144 (69.6%) of them improved their semen parameters, and 63 (30.4%) did not. The optimum cut-off value of SII was 334.6, with an AUC of 0.733 (95% CI: 0.665–0.813). The best cut-off value for SIRI of 0.882, with an AUC of 0.692 (95% CI: 0.607–0.772). The highest sensitivity and specificity were 0.692 and 0.601 ( p < 0.001). In the multivariate analysis, only SII (OR: 3.152, 95% CI: 1.316–7.358; p = 0.003) and SIRI (OR: 2.919, 95% CI: 1.472–5.774; p = 0.002) were independent predictive factors for varicocelectomy success. Conclusions: Our results showed that preoperative SII and SIRI values were lower in infertile patients who underwent successful varicocelectomy. Therefore, we think that these parameters will be useful in identifying patients who will benefit before varicocelectomy.

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Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto’s Thyroiditis

RESBER,

TAKIR,

TORUN

2023

MMJ

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Objective: This study aimed to compare the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values in patients with euthyroid Hashimoto’s thyroiditis (HT) with healthy control subjects. Methods: This was a single-center, retrospective, cross-sectional study conducted on obese patients aged 18 years and over. The medical records of patients who presented with complaints of being overweight at the obesity clinic between April 2017 and May 2019 were examined. Patients and healthy individuals were included in the study consecutively until the sample sizes reached saturation. Patients with diabetes, cardiovascular disease, chronic inflammatory disease, and malignancy were excluded from the study. The patients’ anthropometric measurements, smoking status, blood examination, and thyroid ultrasounds were evaluated. The difference in means between the groups was calculated using the Mann-Whitney U test. Results: The study included 179 participants, consisting of 93 patients and 86 healthy controls. The mean age was 46.6±14.1 years, with most females (91.6%). Although the NLR and PLR values in patients were higher than those in the control group, the difference did not reach statistical significance (p=0.427 and p=0.089, respectively). Furthermore, no significant difference was observed in NLR (p=0.191) and PLR (p=0.668) values between levothyroxine-treated and untreated patients. Correlation analysis revealed weak positive associations between C-reactive protein and thyroid peroxidase antibodies (p<0.05), neutrophils (p<0.01), platelets (p<0.01), and NLR (p<0.05). Conclusions: The findings of this study suggest that NLR and PLR may not serve as effective indicators of systemic inflammation in patients with euthyroid HT, nor do they adequately assess the impact of levothyroxine usage on systemic inflammation.

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Sistemik Lupus Eritematozus Hastalarında İnflamasyon Belirteci ve Yüksek Hastalık Aktivite Göstergesi Olarak Yeni Hematolojik İndeksler

Cited by 4 publications

References 43 publications

The relationship between disease activity with pan-immune-inflammatory value and systemic immune-inflammation index in rheumatoid arthritis

The relationship between disease activity with pan-immune-inflammatory value and systemic immune-inflammation index in rheumatoid arthritis

The effect of systemic inflammatory index and systemic inflammatory response index on success of varicoselectomy

Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in the Patients with Euthyroid Hashimoto’s Thyroiditis

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