Sistemas microfluídicos aplicados na produção de micro e nanopartículas.

Schianti, Juliana de Novais

doi:10.11606/t.3.2012.tde-26072013-173006

Cited by 1 publication

(2 citation statements)

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“…Os processos microfluídicos despertam um grande interesse de cientistas e de empreendedores por possuir grandes vantagens em comparação com os sistemas de transportes de fluidos comuns. A redução de custos, menor quantidade de amostras, portabilidade e possibilidade de acoplar a dispositivos móveis fazem com que o processo microfluidico se torne essencial para as tecnologias futuras (HALLDORSSON et al, 2015;SCHIANTI, 2012;SENTURIA, 2007;SUKHATME et al, 2012).…”

Section: -Vantagens Dos Processos Microfluídicosunclassified

“…As análises fenomenológicas e de operação também se apresentam como vantagens para a utilização de processos microfluidicos. É possível obter um processo contínuo, consumo controlado de reagentes, fluxo laminar com grande transferência de massa e temperatura e baixo tempo de residência (HALLDORSSON et al, 2015;LECAULT et al, 2011;SCHIANTI, 2012).…”

Section: -Vantagens Dos Processos Microfluídicosunclassified

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Simulação numérica de microsseparadores para obtenção de biopartículas do sangue

Oliveira de Souza

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Point of care devices are essential in the race for faster diagnosis and monitoring of blood parameters. As it happens for diabetics with the glucometer, it is possible to use microfluidic devices to evaluate other parameters such as the concentration of interleukins. Microfluidic devices are important in this context as they allow an increase in the concentration of a given parameter by removing other interferers, such as cells. The main method of separation in microfluidics is inertial separation, where the movement of the fluid creates specific conditions of hydrodynamic equilibrium in the particles, aligning them at a specific location in the channel.Therefore, in this work a numerical simulation of microfluidic devices was performed, varying the geometry of each to obtain the best result using the inertial microfluidic method. For the simulation it was necessary to create at least 3 numerical meshes for each microdevice that passed the mesh independence test to determine the mesh to be used. Analyzes were carried out to determine the separation in each device, the formation of the secondary vortex and its evolution throughout the process, to evaluate the change in flow rate and particle size at the entrance of the device. The results of the first device confirm the computational method as a way to predict experimental data, with an error of 5% between the data and making it possible to observe the action of the secondary vortex in the separation result, which was approximately 66%. The other devices were optimizations that generated better separation responses with the addition of curves due to the secondary vortex effect. In both devices the separation was greater than 98%, proving the effect of optimizing the results and microdevice size. Finally, the study shows that inertial microfluidic devices are important for the separation of cells with sizes smaller than 10 µm, which can be proven in other researches with the development of the microdevice in the laboratory.

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Section: -Vantagens Dos Processos Microfluídicosunclassified

Simulação numérica de microsseparadores para obtenção de biopartículas do sangue

Oliveira de Souza

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Sistemas microfluídicos aplicados na produção de micro e nanopartículas.

Cited by 1 publication

References 106 publications

Simulação numérica de microsseparadores para obtenção de biopartículas do sangue

Simulação numérica de microsseparadores para obtenção de biopartículas do sangue

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