Abstract:Serologic methods to determine the Vel-phenotype require the use of rare human antisera and do not allow for many samples to be tested simultaneously, which limits their application as a tool to search for rare donors. This study developed a low-cost molecular screening strategy using the real-time polymerase chain reaction (PCR) with DNA extracted from plasma pools used for viral nucleic acid test (NAT) screening, to identify Vel-and Vel+ W donors. A total of 25,322 blood donors from the Brazilian southeast r… Show more
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