“…In addition, SIRTs are critical regulators of many cellular functions, including longevity, immune and inflammatory responses, DNA damage repair, unfolded protein response, and cell apoptosis [ 4 , 5 , 6 ]. So far, seven SIRTs (SIRT1–7), each with a distinct distribution and subcellular localization, have been reported in mammalian cells [ 4 , 5 , 7 ]. SIRTs are classified into four groups according to their sequence similarities, with class I comprising SIRT1, SIRT2, and SIRT3; class II, SIRT4; class III, SIRT5; and class IV, SIRT6 and SIRT7 [ 8 ].…”