Sirtuins in macrophage immune metabolism: A novel target for cardiovascular disorders

Xu, Chen-qin; Li, Ji; Liang, Zhi-qiang; Zhong, Yi-lang; Zhang, Zhi-hui; Hu, Xue-qing; Cao, Yong-bing; Chen, Jian

doi:10.1016/j.ijbiomac.2023.128270

Cited by 4 publications

(3 citation statements)

References 220 publications

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“…They have an impact on cardiovascular conditions such as atherosclerosis, myocardial infarction, hypertension, and heart failure. Research indicates that metabolic and bioenergetic reprogramming plays a crucial role in regulating inflammation, especially macrophages, serving as critical cells and producers of inflammatory cytokines [ 87 ]. Liu et al demonstrated that the ethanolic extract of LCF, containing C3G, (+)-catechin, and chlorogenic acid, at a concentration of 80 μg/mL, activated sirtuin 1 in Raw264.7 macrophage foam cells.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L.

Bora,

Lombrea,

Batrina

et al. 2024

Antioxidants

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In the light of growing concerns faced by Western societies due to aging, natality decline, and epidemic of cardio-metabolic diseases, both preventable and treatable, new and effective strategical interventions are urgently needed in order to decrease their socio-economical encumbrance. The recent focus of research has been redirected towards investigating the potential of haskap (Lonicera caerulea L.) as a novel functional food or superfruit. Therefore, our present review aims to highlight the latest scientific proofs regarding the potential of Lonicera caerulea L. (LC), a perennial fruit-bearing plant rich in polyphenols, in reversing cardio-metabolic dysfunctions. In this regard, a systematic search on two databases (PubMed and Google Scholar) from 1 January 2016 to 1 December 2023 was performed, the keyword combination being Lonicera caerulea L. AND the searched pharmacological action, with the inclusion criteria consisting of in extenso original articles, written in English. The health-enhancing characteristics of haskap berries have been examined through in vitro and in vivo studies from the 35 included original papers. Positive effects regarding cardiovascular diseases and metabolic syndrome have been assigned to the antioxidant activity, hypolipidemic and hypoglycemic effects, as well as to the hepatoprotective and vasoprotective potential. Latest advances regarding LCF mechanisms of action are detailed within this review as well. All these cutting-edge data suggest that this vegetal product would be a good candidate for further clinical studies.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L.

Bora,

Lombrea,

Batrina

et al. 2024

Antioxidants

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“…The way of NAD + production and/or the supplementation method to modulate or demodulate NAD level might change the subcellular distribution of NAD + inside the cell. Significantly, the ever-increasing result of NAD + modulation by different pharmaceuticals or activators in salvage pathway has shown a wide range of applications for cardiac protection and treatment of CVDs including atherosclerosis, coronary heart disease, hypertension, arrhythmias, and heart failure [ 94 ]. Based on the concept of NAD + , there are two main possibilities in different physiological conditions: either an increase of NAD + or a decrease in the level of NAD + , which can be controlled by treating with NAD + activators and inhibitors, respectively.…”

Section: Prospects Of Enzyme-activated Nad + Synth...mentioning

confidence: 99%

The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection

Kibria,

Das,

Arefin

2024

kitp

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The increasing trend of cardiac diseases is becoming a major threat globally. Cardiac activities are based on integrated action potential through electronic flux changes within intra- and extracellular molecular activities. Nicotinamide adenine dinucleotide (NAD) is a major electron carrier present in almost all living cells and creates gated potential by electron exchange from one chemical to another in terms of oxidation (NAD + ) and reduction (NADH) reactions. NAD + plays an important role directly or indirectly in protecting against various cardiovascular diseases, including heart failure, occlusion, ischemia-reperfusion (IR) injury, arrhythmia, myocardial infarction (MI), rhythmic disorder, and a higher order of cardiovascular complexity. Nicotinamide phosphoribosyl transferase (NAMPT) is well known as a rate-limiting enzyme in this pathway except for de-novo NAD synthesis and directly involved in the cardioprotective activity. There are two more enzymes – nicotinate phosphoribosyl transferase (NAPRT) and nicotinamide riboside kinase (NRK) – which also work as rate-limiting factors in the NAD+ synthesis pathway. This study concentrated on the role of NAMPT, NAPRT, and NRK in cardioprotective activity and prospective cardiac health.

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“…Sirt1 is a nicotinamide adenine dinucleotide dependent class III histone deacetylase, which can regulate the activity of various transcription factors, such as p53, NF-κB, Nrf2, HIF1α, Notch, Forkhead Box O proteins (FoxOs), peroxisome proliferator-activated receptor gamma coactivator 1-Alpha (PGC-1α), and peroxisome proliferator-activated receptor gamma (PPARγ) through deacetylation [ 10 ]. Through these actions, Sirt1 could regulate various physiological functions, like cell differentiation [ 11 ], apoptosis [ 12 ], autophagy [ 13 ], metabolism [ 14 ], inflammation [ 15 ], and oxidative stress [ 16 ]. Studies have confirmed that Sirt1 can modulate macrophage M1/M2 polarization and suppress arthritis inflammation by inactivating the MAPK/NF-κB signaling pathway [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway

Zhao,

Li,

et al. 2024

Inflamm. Res.

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Objective and design To elucidate Sirt1’s role in gouty arthritis inflammation and its potential mechanisms. Material Constructed murine models of gouty arthritis and conducted THP-1 cell experiments. Treatment 1 mg of MSU crystals injected into mice ankle joints for a 72-h intervention. After a 3-h pre-treatment with Sirt1-specific inhibitor (EX527) and agonist (SRT2104), inflammation was induced for 21 h using lipopolysaccharide (LPS) plus MSU crystals. Methods We assessed gouty arthritis severity through joint inflammation index, swelling, and hematoxylin and eosin (H&E) staining, and measured CD68 mononuclear macrophages and Sirt1 expression in synovial tissue via immunohistochemistry. ELISA, NO assay, RT-qPCR, Flow cytometry, and Western blot were utilized to examine macrophage inflammatory factors, polarization, reactive oxygen species(ROS), MAPK/NF-κB/AP-1 and Nrf2/HO-1 pathways proteins. Results Significant joint swelling, synovial tissue edema, and inflammatory cell infiltration were observed. CD68 mononuclear macrophages and Sirt1 expression were elevated in synovium. Sirt1 activation decreased inflammatory factors, M1 polarization, and ROS generation. Sirt1 activation reduced p38/JNK phosphorylation, thereby inhibiting downstream NF-κB p65/AP-1 and enhancing Nrf2/HO-1, thus suppressing inflammation. Conclusions Sirt1 alleviates M1 macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway. Thus, activating Sirt1 may provide a new therapeutic target for gouty arthritis.

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Sirtuins in macrophage immune metabolism: A novel target for cardiovascular disorders

Cited by 4 publications

References 220 publications

A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L.

A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L.

The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection

Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway

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